Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Gunnar, Schulte"'
Autor:
Julian Brands, Sergi Bravo, Lars Jürgenliemke, Lukas Grätz, Hannes Schihada, Fabian Frechen, Judith Alenfelder, Cy Pfeil, Paul Georg Ohse, Suzune Hiratsuka, Kouki Kawakami, Luna C. Schmacke, Nina Heycke, Asuka Inoue, Gabriele König, Alexander Pfeifer, Dagmar Wachten, Gunnar Schulte, Torsten Steinmetzer, Val J. Watts, Jesús Gomeza, Katharina Simon, Evi Kostenis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract A long-held tenet in inositol-lipid signaling is that cleavage of membrane phosphoinositides by phospholipase Cβ (PLCβ) isozymes to increase cytosolic Ca2+ in living cells is exclusive to Gq- and Gi-sensitive G protein-coupled receptors (G
Externí odkaz:
https://doaj.org/article/be62b1c248c547b084b1b6712cdf03af
Autor:
Julien Bous, Julia Kinsolving, Lukas Grätz, Magdalena M. Scharf, Jan Hendrik Voss, Berkay Selcuk, Ogün Adebali, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Frizzleds (ten paralogs: FZD1-10) belong to the class F of G protein-coupled receptors (GPCRs), which remains poorly understood despite its crucial role in multiple key biological functions including embryonic development, stem cell regulati
Externí odkaz:
https://doaj.org/article/2c6eb5ba1bb74b3584d7b89ece24fff5
Autor:
Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, Pawel Kozielewicz, Michael Jahn, Julien Bous, Nevin A. Lambert, David E. Gloriam, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) paralogs and Smoothened, remains one of the most enigmatic GPCR families. This class mediates signaling predominantly through Disheveled (DVL) or
Externí odkaz:
https://doaj.org/article/72a46e442da74ca89e1250cdb8ffac12
Autor:
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113727- (2024)
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with Clostr
Externí odkaz:
https://doaj.org/article/91589d0cdcf74c3ea010aa6edab2a55a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The class Frizzled of G protein-coupled receptors (GPCRs) consist of ten Frizzled (FZD1-10) subtypes and Smoothened (SMO). Here the Schulte laboratory demonstrates that FZDs differ substantially from SMO in receptor activation-associated conformation
Externí odkaz:
https://doaj.org/article/210a27d0ce7040bd89c4edb6636fa89d
Autor:
Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1
Externí odkaz:
https://doaj.org/article/cdfb04c677084c808ef1126575dae7a6
Autor:
Shane C. Wright, Paweł Kozielewicz, Maria Kowalski-Jahn, Julian Petersen, Carl-Fredrik Bowin, Greg Slodkowicz, Maria Marti-Solano, David Rodríguez, Belma Hot, Najeah Okashah, Katerina Strakova, Jana Valnohova, M. Madan Babu, Nevin A. Lambert, Jens Carlsson, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Class F receptors are therapeutic targets in human disease and understanding their structural changes during receptor activation may provide important pharmacological insight. Here, the authors combine computational and experimental methods to identi
Externí odkaz:
https://doaj.org/article/25eb2e5a80d940629421bb3eaf96fb01
Autor:
Julian Petersen, Shane C. Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer di
Externí odkaz:
https://doaj.org/article/9bbfbda480b54f6599ce12e240732064
Autor:
Lukas Grätz, Joanna J. Sajkowska‐Kozielewicz, Janine Wesslowski, Julia Kinsolving, Lloyd J. Bridge, Katja Petzold, Gary Davidson, Gunnar Schulte, Paweł Kozielewicz
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70eaae65ff7db1f116722e8c329f2f3
https://doi.org/10.1111/bph.16090
https://doi.org/10.1111/bph.16090
Autor:
Carl-Fredrik Bowin, Pawel Kozielewicz, Lukas Grätz, Maria Kowalski-Jahn, Hannes Schihada, Gunnar Schulte
Publikováno v:
Science Signaling. 16
Frizzleds (FZDs) are G protein–coupled receptors (GPCRs) that bind to WNT family ligands. FZDs signal through multiple effector proteins, including Dishevelled (DVL), which acts as a hub for several downstream signaling pathways. To understand how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb530cd3cd7d1ea59a5128c12f5c810e
https://doi.org/10.1126/scisignal.abo4974
https://doi.org/10.1126/scisignal.abo4974