Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways

Autor: Jonas Ellegaard Nielsen, Bent Honoré, Karsten Vestergård, Raluca Georgiana Maltesen, Gunna Christiansen, Anna Uhd Bøge, Søren Risom Kristensen, Shona Pedersen

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Alzheimer’s disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging due to the dy

Externí odkaz: https://doaj.org/article/41fc1d200018460e9fa27e434581d2aa

Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α‑Synuclein Fibrillation

Autor: Line Friis Bakmann Christensen, Kirstine Friis Jensen, Janni Nielsen, Brian Stougaard Vad, Gunna Christiansen, Daniel Erik Otzen

Publikováno v: ACS Omega, Vol 4, Iss 2, Pp 4029-4039 (2019)

Externí odkaz: https://doaj.org/article/aad158caa5e94ab883868c291073dfd7

Proteomics dataset: The colon mucosa from inflammatory bowel disease patients, gastrointestinal asymptomic rheumatoid arthritis patients, and controls

Autor: Tue Bjerg Bennike, Thomas Gelsing Carlsen, Torkell Ellingsen, Ole Kristian Bonderup, Henning Glerup, Martin Bøgsted, Gunna Christiansen, Svend Birkelund, Vibeke Andersen, Allan Stensballe

Publikováno v: Data in Brief, Vol 15, Iss , Pp 511-516 (2017)

The datasets presented in this article are related to the research articles entitled âNeutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsiesâ (Bennike et al., 2015 [1]), and âProteome Analysis of Rheumatoi

Externí odkaz: https://doaj.org/article/a1f513ec70574dfd8ba61fdd7d681ffc

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

Autor: Cagla Sahin, Eva Christina Østerlund, Nicklas Österlund, Joana Costeira-Paulo, Jannik Nedergaard Pedersen, Gunna Christiansen, Janni Nielsen, Anne Louise Grønnemose, Søren Kirk Amstrup, Manish K. Tiwari, R. Shyama Prasad Rao, Morten Jannik Bjerrum, Leopold L. Ilag, Michael J. Davies, Erik G. Marklund, Jan Skov Pedersen, Michael Landreh, Ian Max Møller, Thomas J. D. Jørgensen, Daniel Erik Otzen

Publikováno v: Sahin, C, Østerlund, E C, Österlund, N, Costeira-Paulo, J, Pedersen, J N, Christiansen, G, Nielsen, J, Grønnemose, A L, Amstrup, S K, Tiwari, M K, Rao, R S P, Bjerrum, M J, Ilag, L L, Davies, M J, Marklund, E G, Pedersen, J S, Landreh, M, Møller, I M, Jørgensen, T J D & Otzen, D E 2022, ' Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization ', Journal of the American Chemical Society, vol. 144, no. 27, pp. 11949-11954 . https://doi.org/10.1021/jacs.2c03607
Sahin, C, Osterlund, E C, Osterlund, N, Costeira-Paulo, J, Pedersen, J N, Christiansen, G, Nielsen, J, Grønnemose, A L, Amstrup, S K, Tiwari, M K, Rao, R S P, Bjerrum, M J, Ilag, L L, Davies, M J, Marklund, E G, Pedersen, J S, Landreh, M, Moller, I M, Jorgensen, T J D & Otzen, D E 2022, ' Structural Basis for Dityrosine-Mediated Inhibition of alpha-Synuclein Fibrillization ', Journal of the American Chemical Society, vol. 144, no. 27, pp. 11949-11954 . https://doi.org/10.1021/jacs.2c03607

alpha-Synuclein (alpha-Syn) is an intrinsically disordered protein which self-assembles into highly organized beta-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences alpha-Syn structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a12848347027ec45af73136d3afcb59
https://doi.org/10.1021/jacs.2c03607

Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.

Autor: Femke van Diggelen, Dean Hrle, Mihaela Apetri, Gunna Christiansen, Gerhard Rammes, Armand Tepper, Daniel Erik Otzen

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213663 (2019)

Parkinson's Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggregation of the pre-synaptic protein α-synuclein (aSN) into oligomers (αSOs) is believed to play a key role in PD pathology, but little is known about

Externí odkaz: https://doaj.org/article/79493b1090b74cd88741eba920d51436