Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability

Autor: Ng, B, Rowland, HA, Wei, T, Arunasalam, K, Hayes, EM, Koychev, I, Hedegaard, A, Ribe, EM, Chan, D, Chessell, T, Ffytche, D, Gunn, RN, Kocagoncu, E, Lawson, J, Malhotra, PA, Ridha, BH, Rowe, JB, Thomas, AJ, Zamboni, G, Buckley, NJ, Cader, ZM, Lovestone, S, Wade-Martins, R

Establishing preclinical models of Alzheimer’s disease that predict clinical outcomes remains a critically important, yet to date not fully realized, goal. Models derived from human cells offer considerable advantages over non-human models, includi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3662dae48d7ca1f3306914436d93df
https://www.repository.cam.ac.uk/handle/1810/344192

Tau(IQ): A Canonical Image Based Algorithm to Quantify Tau PET Scans

Autor: Whittington, A, Gunn, RN, Alzheimer’s Disease Neuroimaging Initiative

Publikováno v: J Nucl Med

Recently, Amyloid(IQ) was introduced as a new canonical image-based algorithm to quantify amyloid PET scans and demonstrated increased power over traditional SUV ratio (SUVR) approaches when assessed in cross-sectional and longitudinal analyses. We b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a440d4dffe14d79df53cc90d31d0e1
https://europepmc.org/articles/PMC8882899/

Spatiotemporal distribution of β-amyloid in Alzheimer's disease results from heterogeneous regional carrying capacities

Autor: Whittington, A, Sharp, DJ, Gunn, RN

β-amyloid (Aβ) accumulation in the brain is one of two pathological hallmarks of Alzheimer's Disease (AD) and its spatial distribution has been studied extensively ex vivo. We apply mathematical modelling to Aβ in vivo PET imaging data in order to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::2e1657727d07c93ac606b39f1091ce27
http://hdl.handle.net/10044/1/54197

Brain microglia in psychiatric disorders

Autor: Mondelli, Valeria, Vernon, Anthony C, Turkheimer, Federico, Dazzan, Paola, Pariante, Carmine M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., et, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, Peferoen, LA, Vogel, DY, Ummenthum, K, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Steiner, J, Bielau, H, Brisch, R, Schnieder, TP, Trencevska, I, Rosoklija, G, Fillman, SG, Cloonan, N, Catts, VS, Rupprecht, R, Papadopoulos, V, Rammes, G, Qiu, ZK, Li, MS, He, JL, Hannestad, J, Gallezot, JD, Schafbauer, T, Israel, I, Ohsiek, A, Al-Momani, E, Mirzaei, N, Tang, SP, Ashworth, S, Gulyás, B, Makkai, B, Kása, P, Turkheimer, FE, Rizzo, G, Bloomfield, PS, Owen, DR, Yeo, AJ, DellaGioia, N, Setiawan, E, Wilson, AA, Su, L, Faluyi, YO, Hong, YT, Haarman, BC, Lek, RF Riemersma-Van der, Groot, JC de, Berckel, BN van, Bossong, MG, Boellaard, R, Doorduin, J, Vries, EF de, Willemsen, AT, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, Kenk, M, Selvanathan, T, Rao, N, Selvaraj, S, Veronese, M, Coughlin, JM, Wang, Y, Ambinder, EB, Doef, TF van der, Witte, LD de, Sutterland, AL, Hafizi, S, Tseng, HH, Holmes, SE, Hinz, R, Drake, RJ, Yaqub, M, Schuitemaker, A, Edison, P, Pavese, N, Lockhart, A, Davis, B, Matthews, JC, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, Cahn, W, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Brocklehurst, S, Miller, DH, Kubicki, M, Park, H, Westin, CF, Bouix, S, Dahlben, B, Oestreich, LK, Shenton, ME, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Ambler, A, Poulton, R, Caspi, A, Akhtar, R, Ciufolini, S, Meyer, U, So, PW, Lythgoe, DJ, Cotel, MC, Lenartowicz, EM, Anacker, C, Calcia, MA, Bonsall, DR, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F La, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Gschwind, T, Varga, B, Markó, K, Hádinger, N, Cattaneo, A, Ferrari, C, Uher, R, Belvederi, Murri M, Sandiego, CM, Pittman, B, Weber, MD, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Bard, F, Bhattacharya, A, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N

Publikováno v: Lancet psychiatry, 0(0), 587-597. Elsevier Limited
Mondelli, V, Vernon, A C, Turkheimer, F E, Dazzan, P & Pariante, C M 2017, ' Brain microglia in psychiatric disorders ', The Lancet Psychiatry, vol. 4, no. 7, pp. 563-572 . https://doi.org/10.1016/S2215-0366(17)30101-3
Mondelli, V, Vernon, A C, Turkheimer, F, Dazzan, P, Pariante, C M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., E, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, al., E, Peferoen, LA, Vogel, DY, Ummenthum, K, al., E, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, al., E, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Mechawar, N, Steiner, J, Bielau, H, Brisch, R, al., E, Schnieder, TP, Trencevska, I, Rosoklija, G, al., E, Fillman, SG, Cloonan, N, Catts, VS, al., E, Rupprecht, R, Papadopoulos, V, Rammes, G, al., E, Qiu, ZK, Li, MS, He, JL, al., E, Hannestad, J, Gallezot, JD, Schafbauer, T, al., E, Israel, I, Ohsiek, A, Al-Momani, E, al., E, Mirzaei, N, Tang, SP, Ashworth, S, al., E, Gulyás, B, Makkai, B, Kása, P, al., E, Turkheimer, FE, Rizzo, G, Bloomfield, PS, al., E, Owen, DR, Yeo, AJ, Gunn, RN, al., E, Hannestad, J, DellaGioia, N, Gallezot, JD, al., E, Setiawan, E, Wilson, AA, Mizrahi, R, al., E, Su, L, Faluyi, YO, Hong, YT, al., E, Haarman, BC, Lek, RF R-V D, Groot, JC D, al., E, Berckel, BN V, Bossong, MG, Boellaard, R, al., E, Doorduin, J, Vries, EF D, Willemsen, AT, Groot, JC D, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, al., E, Kenk, M, Selvanathan, T, Rao, N, al., E, Bloomfield, PS, Selvaraj, S, Veronese, M, al., E, Coughlin, JM, Wang, Y, Ambinder, EB, al., E, Doef, TF V D, Witte, LD D, Sutterland, AL, al., E, Hafizi, S, Tseng, HH, Rao, N, al., E, Holmes, SE, Hinz, R, Drake, RJ, al., E, Yaqub, M, Berckel, BN V, Schuitemaker, A, al., E, Turkheimer, FE, Edison, P, Pavese, N, al., E, Lockhart, A, Davis, B, Matthews, JC, al., E, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, al., E, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, al., E, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, al., E, Mandl, RC, Pasternak, O, Cahn, W, al., E, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Barker, GJ, Brocklehurst, S, Miller, DH, Ron, MA, Foong, J, Symms, MR, Barker, GJ, al., E, Kubicki, M, Park, H, Westin, CF, al., E, Bagary, MS, Foong, J, Maier, M, al., E, Pasternak, O, Westin, CF, Bouix, S, Pasternak, O, Westin, CF, Dahlben, B, Bouix, S, Kubicki, M, Oestreich, LK, Pasternak, O, Shenton, ME, al., E, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, al., E, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A, Baumeister, D, Akhtar, R, Ciufolini, S, Pariante, CM, Mondelli, V, Meyer, U, Vernon, AC, So, PW, Lythgoe, DJ, al., E, Cotel, MC, Lenartowicz, EM, Natesan, S, al., E, Mondelli, V, Anacker, C, Vernon, AC, al., E, Calcia, MA, Bonsall, DR, Bloomfield, PS, Selvaraj, S, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F L, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Coughlin, JM, Gschwind, T, al., E, Varga, B, Markó, K, Hádinger, N, al., E, Cattaneo, A, Ferrari, C, Uher, R, al., E, Mondelli, V, Ciufolini, S, Belvederi, M M, al., E, Sandiego, CM, Gallezot, JD, Pittman, B, al., E, Weber, MD, Godbout, JP, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, al., E, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, al., E, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Möller, T, Bard, F, Bhattacharya, A, al., E, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N, Baumeister, D, Ciufolini, S & Mondelli, V 2016, ' Brain microglia in psychiatric disorders ', Lancet psychiatry, vol. 0, no. 0, pp. 587-597 . https://doi.org/10.1016/S2215-0366(17)30101-3

SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1698f7e9b3eca5ef43eb16cacb00b091
https://research.vumc.nl/en/publications/07f168d1-2b4d-4483-b9b1-1659ff4e83f8

Uptake of [N-methyl-C-11]propionyl-L-carnitine (PLC) in human myocardium

Autor: Cunningham VJ, Rosen SD, Boyd H, Osman S, Davenport RJ, Gunn RN, Pike VW, CAMICI , PAOLO

We studied the uptake of propionyl-L-carnitine from plasma by the myocardium in 10 human subjects using positron emission tomography. Propionyl-L-carnitine was labeled in the N-methyl position with carbon-11 (T 1/2 = 20 4 min) and administered i.v. i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10495::c1d59b3527c5bae6cb36781e02f4f013