Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gunn A. Hildrestrand"'
Autor:
Gunn A. Hildrestrand, Veslemøy Rolseth, Nicolas Kunath, Rajikala Suganthan, Vidar Jensen, Anna M. Bugaj, Marion S. Fernandez-Berrocal, Sunniva B. Sikko, Susanne Vetlesen, Anna Kuśnierczyk, Ann-Karin Olsen, Kristine B. Gützkow, Alexander D. Rowe, Wei Wang, Olve Moldestad, Monica D. Syrstad, Geir Slupphaug, Lars Eide, Arne Klungland, Pål Sætrom, Luisa Luna, Jing Ye, Katja Scheffler, Magnar Bjørås
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair. Their results suggest that loss of both NEIL1 and NEIL2 dysregulates genes relevant to synapti
Externí odkaz:
https://doaj.org/article/36b704fa17dc44b1933173201d933187
Autor:
Mingyi Yang, Xiaolin Lin, Filip Segers, Rajikala Suganthan, Gunn A. Hildrestrand, Johanne E. Rinholm, Per Arne Aas, Mirta M.L. Sousa, Sverre Holm, Nils Bolstad, David Warren, Rolf K. Berge, Rune F. Johansen, Arne Yndestad, Elise Kristiansen, Arne Klungland, Luisa Luna, Lars Eide, Bente Halvorsen, Pål Aukrust, Magnar Bjørås
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4165-4178.e7 (2020)
Summary: Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates decreased growt
Externí odkaz:
https://doaj.org/article/247c0649b261428588cdfcf101aa6b70
Autor:
Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G. Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A. Hildrestrand, Anne Graupner, Jill M. Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The
Externí odkaz:
https://doaj.org/article/5c917068e02c43e0970c726380db6068
Autor:
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2671-2678 (2015)
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−M
Externí odkaz:
https://doaj.org/article/4ac21c419fc4404d848fbcaac9fd6541
Autor:
Mirta M. L. Sousa, Rolf K. Berge, Filip M. Segers, Nils Bolstad, Gunn A. Hildrestrand, Luisa Luna, Pål Aukrust, Lars Eide, Magnar Bjørås, Bente Halvorsen, Elise Kristiansen, David J. Warren, Rune F. Johansen, Johanne Egge Rinholm, Rajikala Suganthan, Sverre Holm, Per Arne Aas, Arne Klungland, Mingyi Yang, Arne Yndestad, Xiaolin Lin
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4165-4178.e7 (2020)
Cell reports
Cell reports
Summary: Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates decreased growt
Autor:
Jing Ye, Mirta M. L. Sousa, Gunn A. Hildrestrand, Luisa Luna, Katja Scheffler, Karine Øian Bjørås, Magnar Bjørås
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12924, p 12924 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The human brain requires a high rate of oxygen consumption to perform intense metabolic activities, accounting for 20% of total body oxygen consumption. This high oxygen uptake results in the generation of free radicals, including reactive oxygen spe
Autor:
Gunn A. Hildrestrand, Pål Sætrom, Magnar Bjørås, Olsen A, Lars Eide, Wei Wang, Rajikala Suganthan, Bøe Sikko S, Rolseth, Syrstad, Anna Maria Bugaj, Arne Klungland, Jing Ye, Marion Silvana Fernandez-Berrocal, Kristine B. Gutzkow, Olve Moldestad, Katja Scheffler, Luisa Luna, Jensen, Geir Slupphaug, Susanne Vetlesen, Nicolas Kunath, Alexander D. Rowe, Anna Kuśnierczyk
Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases alter cogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c4aa6999c8a870042bff0f4074a982c
https://doi.org/10.1101/2021.02.08.430208
https://doi.org/10.1101/2021.02.08.430208
Autor:
Veslemøy Rolseth, Gunn A. Hildrestrand, Arne Klungland, Sunniva B. Sikko, Jing Ye, Marion Silvana Fernandez-Berrocal, Magnar Bjørås, Alexander D. Rowe, Pål Sætrom, Geir Slupphaug, Rajikala Suganthan, Nicolas Kunath, Wei Wang, Luisa Luna, Katja Scheffler, Susanne Vetlesen, Vidar Jensen, Anna Kuśnierczyk, Lars Eide, Monica D. Syrstad, Ann-Karin Olsen, Anna Maria Bugaj, Kristine B. Gutzkow, Olve Moldestad
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cog
Autor:
Veslemøy Rolseth, Lars Eide, Susanne Vetlesen, Gunn A. Hildrestrand, Cathrine Broberg Vågbø, Monica D. Bjørge, Katja Scheffler, Rajikala Suganthan, Yusaku Nakabeppu, Magnar Bjørås, Arne Klungland, Timothy W. Bredy, Geir Slupphaug, Alexander D. Rowe, Anna Kuśnierczyk
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2671-2678 (2015)
Cell reports
Cell reports
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−M
Autor:
Christine G. Neurauter, Vuk Palibrk, Lili Zhang, Pål Sætrom, William E. Louch, Ingunn Østlie, Sverre-Henning Brorson, Lars Gullestad, Junbai Wang, Ivar Sjaastad, Ingrid Kristine Ohm, Katrine Alfsnes, Magnar Bjørås, Jonas Øgaard, Geir Christensen, Arne Yndestad, Per Ole Iversen, Arnt E. Fiane, Maria Belland Olsen, Geir Slupphaug, Gunn A. Hildrestrand, Pål Aukrust, Jostein Johansen, Arne Klungland, Anna Kuśnierczyk, Leif Erik Vinge, Luisa Luna, Alexandra Vanessa Finsen, Katja Scheffler
Publikováno v:
Cell reports
Myocardial infarction (MI) triggers a reparative response involving fibroblast proliferation and differentiation driving extracellular matrix modulation necessary to form a stabilizing scar. Recently, it was shown that a genetic variant of the base e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398a3496b35088cd0c3b7fe83fe856d7
https://hdl.handle.net/11250/2478007
https://hdl.handle.net/11250/2478007