Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gunji Yamashita"'
Publikováno v:
Journal of Gastroenterology and Hepatology. 14:578-582
Background: Several organic anions cause dissociation of biliary lipid secretion from bile acid secretion (uncoupling). As bile lipids originate from liver microsomes and are transported by carrier proteins and/or transcytotic vesicles, such a reduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c6c356648130ba7639821e64d1e1995
https://doi.org/10.1046/j.1440-1746.1999.01917.x
https://doi.org/10.1046/j.1440-1746.1999.01917.x
Publikováno v:
Journal of Gastroenterology and Hepatology. 14:388-393
Background: Phospholipid species modulate cholesterol-holding capacity and, therefore, regulate bile metastability. Methods: In this study, we investigated the effect of bile salt hydrophobicity on the distribution of phospholipids among lipid partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb187bcbb765d523cdbd699b69e2f683
https://doi.org/10.1046/j.1440-1746.1999.01858.x
https://doi.org/10.1046/j.1440-1746.1999.01858.x
Publikováno v:
Journal of Gastroenterology. 35:450-455
We recently demonstrated that several organic anions cause dissociation of biliary lipid secretion from that of bile acids; namely, the "uncoupling phenomenon," in association with changes in the phospholipid molecular species in the canalicular memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a1114fa47a6c9730830a97dfac42d5
https://doi.org/10.1007/s005350070091
https://doi.org/10.1007/s005350070091
Autor:
Hidenori Ochi, Yasushi Sunami, Tsuyoshi Kajihara, Shigeyuki Yasumiba, Goro Kajiyama, Kuniharu Nakai, Gunji Yamashita, Kazuhiko Tsuboi, Yoshihiro Hattori, Hideyuki Hyogo, Yasumasa Asamoto, Minoru Sakomoto, Tomoji Nishioka, Susumu Tazuma
Publikováno v:
Digestive Diseases and Sciences. 45:1413-1421
Phospholipase A2 plays a role in cholesterol gallstone development by hydrolyzing bile phospholipids into lysolecithin and free fatty acids. Lysolecithin and polyunsaturated free fatty acids are known to stimulate the synthesis and/or secretion of ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c27c2976d6f97541c9928fc714fa278f
https://doi.org/10.1023/a:1005524624411
https://doi.org/10.1023/a:1005524624411
Publikováno v:
Journal of Gastroenterology and Hepatology. 14:669-674
Background: In lithogenic bile, cholesterol-rich vesicles rapidly aggregate and fuse to eventually form cholesterol crystals. This process is modulated by cholesterol crystallization effector substances. In this study, we developed a method for quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a8d7c506defc95d169767a9fa07ab0
https://doi.org/10.1046/j.1440-1746.1999.01933.x
https://doi.org/10.1046/j.1440-1746.1999.01933.x
Publikováno v:
Biochemical Journal. 340:445-451
Cholesterol crystallization is a key step in gallstone formation and is influenced by numerous factors. Human bile contains various bile salts having different hydrophobicity and micelle-forming capacities, but the importance of lipid composition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb1e8227c98b8ca47d03fa19e0cbc88
https://doi.org/10.1042/bj3400445
https://doi.org/10.1042/bj3400445
Publikováno v:
Digestive Diseases and Sciences. 44:197-202
Bile salts regulate the subselection ofphosphatidylcholine species secreted into bile andthereby modulate bile metastability. The aim of thisstudy was to determine whether bile salts alterphosphatidylcholine species of the canalicular membrane, and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469ebd49abd120b989ecb0eac2474a39
https://doi.org/10.1023/a:1026687108185
https://doi.org/10.1023/a:1026687108185
Publikováno v:
Journal of Gastroenterology and Hepatology. 13:1161-1170
Various proteins which affect cholesterol crystallization are known to be present in bile, although the relative potency of their action is yet to be established. In this study, we evaluated the comparative potency of nucleating-effector proteins usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d47c191f66f9eb5fe0dd0ba67f3044e
https://doi.org/10.1111/j.1440-1746.1998.tb00594.x
https://doi.org/10.1111/j.1440-1746.1998.tb00594.x
Publikováno v:
Biochemical Journal. 332:343-350
The crystallization of cholesterol is affected by various factors in bile. The present study evaluated the relative importance of cholesterol-nucleation-promoting factors and partially characterized the mechanisms of their action. Model biles with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c723192ada6bfd2b3f59ebeb8abc8cc
https://doi.org/10.1042/bj3320343
https://doi.org/10.1042/bj3320343
Autor:
Hiroaki Miyake, Taiji Matsumoto, Shigeyoshi Ohguri, Hiroyuki Miura, Toshiyuki Mizuno, Shigeyuki Yasumiba, Hidenori Ochi, Ken Adachi, Fumio Omata, Gunji Yamashita, Yasushi Sunami, Hisao Shibata, Goro Kajiyama, Fumiaki Ueno, Fumio Sugata, Tomoji Nishioka, Susumu Tazuma, Yoshihiro Hattori, Hideyuki Hyogo, Akio Abe, Tsuyoshi Kajihara, Shigehiro Kokubu
Publikováno v:
Journal of Clinical Gastroenterology. 26:287-291
Inhibitors of 3-hydroxy,3-methylglutaryl coenzyme A (HMG-CoA) reductase have been reported to decrease the cholesterol saturation index (CSI) in duodenal bile in humans and to prevent formation of cholesterol gallstones in animal studies. We performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7696aa25bf9d1e6bf1b438c936627736
https://doi.org/10.1097/00004836-199806000-00015
https://doi.org/10.1097/00004836-199806000-00015