Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gunjan Sethia"'
Autor:
Priscillia Lhoumaud, Gunjan Sethia, Franco Izzo, Theodore Sakellaropoulos, Valentina Snetkova, Simon Vidal, Sana Badri, Macintosh Cornwell, Dafne Campigli Di Giammartino, Kyu-Tae Kim, Effie Apostolou, Matthias Stadtfeld, Dan Avi Landau, Jane Skok
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Activation of regulatory elements is thought to be inversely correlated with DNA methylation levels. However, it is difficult to determine whether DNA methylation is compatible with chromatin accessibility or transcription factor (TF) bindin
Externí odkaz:
https://doaj.org/article/05d80c0806d0468d85038fa65c963014
Autor:
Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, Theodore Sakellaropoulos, Gunjan Sethia, Andreas Kloetgen, MacIntosh Cornwell, Sourya Bhattacharyya, Ferhat Ay, Richard Bonneau, Aristotelis Tsirigos, Jane A. Skok
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster wit
Externí odkaz:
https://doaj.org/article/a9714ab2ecf84d2fb21b384d6ebd3d76
Autor:
Stephanie Lauer, Grace Avecilla, Pieter Spealman, Gunjan Sethia, Nathan Brandt, Sasha F Levy, David Gresham
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e3000069 (2018)
Copy number variants (CNVs) are a pervasive source of genetic variation and evolutionary potential, but the dynamics and diversity of CNVs within evolving populations remain unclear. Long-term evolution experiments in chemostats provide an ideal syst
Externí odkaz:
https://doaj.org/article/8979b08154c34000bcd0157db9dddafe
Autor:
William L. Carroll, Nikki A. Evensen, Aristotelis Tsirigos, Xiaotu Ma, Jinghui Zhang, Patrick A. Brown, Mignon L. Loh, Jun J. Yang, Kjeld Schmiegelow, David T. Teachey, Tori J. Fuller, Takaya Moriyama, Harrison L. Kilberg, Hannah Fay, Anita Qualls, Ashfiyah Chowdhury, Shella Saint Fleur-Lominy, Gunjan Sethia, Sonali Narang, Jason Saliba, Joanna Pierro
Cell line IC50 values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e42955567a62723486f8dfda7696ce2
https://doi.org/10.1158/1541-7786.22517911.v1
https://doi.org/10.1158/1541-7786.22517911.v1
Autor:
William L. Carroll, Nikki A. Evensen, Aristotelis Tsirigos, Xiaotu Ma, Jinghui Zhang, Patrick A. Brown, Mignon L. Loh, Jun J. Yang, Kjeld Schmiegelow, David T. Teachey, Tori J. Fuller, Takaya Moriyama, Harrison L. Kilberg, Hannah Fay, Anita Qualls, Ashfiyah Chowdhury, Shella Saint Fleur-Lominy, Gunjan Sethia, Sonali Narang, Jason Saliba, Joanna Pierro
Supplementary materials and methods and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02609ec252e8f6b3c330df28d01077e1
https://doi.org/10.1158/1541-7786.22517914
https://doi.org/10.1158/1541-7786.22517914
Autor:
William L. Carroll, Nikki A. Evensen, Aristotelis Tsirigos, Xiaotu Ma, Jinghui Zhang, Patrick A. Brown, Mignon L. Loh, Jun J. Yang, Kjeld Schmiegelow, David T. Teachey, Tori J. Fuller, Takaya Moriyama, Harrison L. Kilberg, Hannah Fay, Anita Qualls, Ashfiyah Chowdhury, Shella Saint Fleur-Lominy, Gunjan Sethia, Sonali Narang, Jason Saliba, Joanna Pierro
RNAseq Gene Lists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7985eb3a5f95dead1cf23e568fefcd43
https://doi.org/10.1158/1541-7786.22517905
https://doi.org/10.1158/1541-7786.22517905
Autor:
William L. Carroll, Nikki A. Evensen, Aristotelis Tsirigos, Xiaotu Ma, Jinghui Zhang, Patrick A. Brown, Mignon L. Loh, Jun J. Yang, Kjeld Schmiegelow, David T. Teachey, Tori J. Fuller, Takaya Moriyama, Harrison L. Kilberg, Hannah Fay, Anita Qualls, Ashfiyah Chowdhury, Shella Saint Fleur-Lominy, Gunjan Sethia, Sonali Narang, Jason Saliba, Joanna Pierro
S1. Schematic diagram of NSD2 isoform indicating domains, the location of amino acid E1099 within the SET domain, and the targets of the shRNAs. S2. NSD2 Overexpression in B-ALL Cell Lines Does Not Impart Clonal Advantage. S3. Overexpression of REIIB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c2a09c674f1974fe7cb26e6b312bc1
https://doi.org/10.1158/1541-7786.22517917.v1
https://doi.org/10.1158/1541-7786.22517917.v1
Autor:
Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Xiaotu Ma, Sonali Narang, Christopher E. Mason, Nikki A. Evensen, Kylie M. Getz, Aristotelis Tsirigos, Jun H. Choi, Shella Saint Fleur-Lominy, Stephen Kelly, Gunjan Sethia, Cem Meydan, Richard C. Harvey, Jun J. Yang, Teena Bhatla, William L. Carroll, Patrick A. Brown, Cheryl L. Willman
Publikováno v:
Cancer Res
Although B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children and while highly curable, it remains a leading cause of cancer-related mortality. The outgrowth of tumor subclones carrying mutations in genes responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c0442e97661eac0bf34800d8057a03
https://pubmed.ncbi.nlm.nih.gov/33067268
https://pubmed.ncbi.nlm.nih.gov/33067268
Autor:
Aristotelis Tsirigos, Harrison L. Kilberg, Joanna Pierro, David T. Teachey, Xiaotu Ma, Nikki A. Evensen, Ashfiyah Chowdhury, William L. Carroll, Gunjan Sethia, Jinghui Zhang, Mignon L. Loh, Takaya Moriyama, Sonali Narang, Jason Saliba, Shella Saint Fleur-Lominy, Jun J. Yang, Patrick A. Brown, Tori Fuller, Kjeld Schmiegelow, Anita Qualls, Hannah Fay
Publikováno v:
Mol Cancer Res
The NSD2 p.E1099K (EK) mutation is observed in 10% of acute lymphoblastic leukemia (ALL) samples with enrichment at relapse indicating a role in clonal evolution and drug resistance. To discover mechanisms that mediate clonal expansion, we engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3769abf76bbb9ff457773b9724ed0a
https://pubmed.ncbi.nlm.nih.gov/32332049
https://pubmed.ncbi.nlm.nih.gov/32332049
Autor:
Sourya Bhattacharyya, MacIntosh Cornwell, Theodore Sakellaropoulos, Aristotelis Tsirigos, Andreas Kloetgen, Sana Badri, Ferhat Ay, Priscillia Lhoumaud, Javier Rodriguez Hernaez, Jane A. Skok, Gunjan Sethia, Richard Bonneau
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
CTCF and cohesin play a key role in organizing chromatin into topologically associating domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change chromosomal interactions leading to alterations in chromatin modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb3bfb9388af0c4af697f484fc23d48
https://doi.org/10.1038/s41467-019-12811-4
https://doi.org/10.1038/s41467-019-12811-4