Symmetrical 2,7-disubstituted 9H-fluoren-9-one as a novel and promising scaffold for selective targeting of SIRT2.

Autor: Kaya SG; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Eren G; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Massarotti A; Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, 'A. Avogadro', Novara, Italy., Gunindi HB; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Bakar-Ates F; Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Türkiye., Ozkan E; Department of Biochemistry, Faculty of Pharmacy, Ankara Medipol University, Ankara, Türkiye.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Dec; Vol. 357 (12), pp. e2400661. Date of Electronic Publication: 2024 Sep 28.

In silico approach reveals N -(5-phenoxythiophen-2-yl)-2-(arylthio)acetamides as promising selective SIRT2 inhibitors: the case of structural optimization of virtual screening-derived hits.

Autor: Gozelle M; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Bakar-Ates F; Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Türkiye., Massarotti A; Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, 'A. Avogadro', Novara, Italy., Ozkan E; Department of Biochemistry, Faculty of Pharmacy, Ankara Medipol University, Ankara, Türkiye., Gunindi HB; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Ozkan Y; Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye., Eren G; SIRTeam Group, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Türkiye.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2023 Dec 19, pp. 1-12. Date of Electronic Publication: 2023 Dec 19.