Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gunilla Thulin"'
Publikováno v:
Journal of the American Society of Nephrology
Renal ischemia and reperfusion injury causes loss of renal epithelial cell polarity and perturbations in tubular solute and fluid transport. Na(+),K(+)-ATPase, which is normally found at the basolateral plasma membrane of renal epithelial cells, is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab4702a836151723c299e2bbe855e24
https://doi.org/10.1681/asn.2013101040
https://doi.org/10.1681/asn.2013101040
Autor:
Patricia Seo-Mayer, Daiane S. Alves, Michael J. Caplan, Li Zhang, Thomas Ardito, Gunilla Thulin, Michael Kashgarian
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F1346-F1357
Alterations in epithelial cell polarity and in the subcellular distributions of epithelial ion transport proteins are key molecular consequences of acute kidney injury and intracellular energy depletion. AMP-activated protein kinase (AMPK), a cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5920cf0707456874bdb93392c1fc0
https://doi.org/10.1152/ajprenal.00420.2010
https://doi.org/10.1152/ajprenal.00420.2010
Autor:
Shirley B. Wang, Michael Riordan, Norman J. Siegel, Michael Kashgarian, Gunilla Thulin, Rajasree Sreedharan
Publikováno v:
American Journal of Physiology-Renal Physiology. 288:F322-F326
Immature animals demonstrate an amplified heat shock response following a variety of insults compared with that seen in mature animals (M). The potential role of the heat shock response in modulating immature tolerance to injury was compared between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5f1fab23639da73f1f9ea033f9960e
https://doi.org/10.1152/ajprenal.00307.2004
https://doi.org/10.1152/ajprenal.00307.2004
Publikováno v:
Journal of the American Society of Nephrology. 15:1557-1566
To test a putative cause and effect relationship between heat-shock protein (HSP) expression and response to renal cell injury, HSP72 and HSP25 were differentially inhibited in LLC-PK1 cells by means of transcription factor decoy and short interferen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d222a36fb2ce76f57f79ef4766ca8a14
https://doi.org/10.1097/01.asn.0000127996.42634.2b
https://doi.org/10.1097/01.asn.0000127996.42634.2b
Autor:
Bettina Bidmon, Gunilla Thulin, Michael Kashgarian, A. S. Mann, Norman J. Siegel, Karen M. Gaudio, Julie Ryu, Kim Reidy, Alfin G. Vicencio
Publikováno v:
Pediatric Nephrology. 18:85-91
The resistance of the immature kidney to ischemic injury is well documented, but the mechanisms involved in this tolerance have been elusive. Previous studies have demonstrated that tubules obtained from immature rats exhibit a bigger stress response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27895259953ff9dd015a313533d3b2fb
https://doi.org/10.1007/s00467-002-1008-x
https://doi.org/10.1007/s00467-002-1008-x
Autor:
Michael Kashgarian, Sarah Ferris, A. S. Mann, Norman J. Siegel, Thomas Ardito, Gunilla Thulin, Megan A. Macleod, Scott K. Van Why
Publikováno v:
Journal of the American Society of Nephrology. 14:98-106
The purpose of the study was to determine whether Hsp27 interacts with actin and could protect against selected manifestations of injury from energy depletion in renal epithelia. LLC-PK1 cells were stably transfected to overexpress human Hsp27 tagged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139bf0074bb7f1b07e45a7a48079dc81
https://doi.org/10.1097/01.asn.0000038687.24289.83
https://doi.org/10.1097/01.asn.0000038687.24289.83
Publikováno v:
American Journal of Physiology-Renal Physiology. 274:F1029-F1036
The stress response was studied in suspensions of tubules from immature (IT) and mature (MT) rats after noninjury, heat, oxygen, and anoxia. Under all conditions, IT exhibited more exuberant activation of heat shock transcription factor (HSF) than MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c8ccc8b40b22f547898db277831cb5
https://doi.org/10.1152/ajprenal.1998.274.6.f1029
https://doi.org/10.1152/ajprenal.1998.274.6.f1029
Autor:
Norman J. Siegel, Thomas Ardito, Scott K. Van Why, Christoph Aufricht, Michael Kashgarian, Gunilla Thulin
Publikováno v:
American Journal of Physiology-Renal Physiology. 274:F215-F222
The small heat-shock proteins appear to have a regulatory role in actin dynamics. Since cytoskeletal disruption is integral to ischemic renal injury, we evaluated expression and intracellular distribution of heat-shock protein 25 (HSP-25) in rat rena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce39bd5d0452314675bcaa258cf4dde
https://doi.org/10.1152/ajprenal.1998.274.1.f215
https://doi.org/10.1152/ajprenal.1998.274.1.f215
Publikováno v:
Pediatric Nephrology. 11:757-760
The tolerance of immature tissues to injury has been noted over the past several decades. Traditional teaching relates this tolerance to energy derived from anaerobic glycolysis. This mini-review describes investigations of the hypothesis that the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700b09dcdd7a3b30cdb063302f53900a
https://doi.org/10.1007/s004670050384
https://doi.org/10.1007/s004670050384
Publikováno v:
Pediatric Research. 40:457-461
We have previously shown that the immature tubule is tolerant of prolonged anoxia. In addition, cellular ATP is maintained at 2-fold higher levels during anoxia in the immature tubules compared with the mature tubules. The purpose of this study was:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a1ebd57c19331dafc35fdcccbc0ace
https://doi.org/10.1203/00006450-199609000-00015
https://doi.org/10.1203/00006450-199609000-00015