Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Gunilla T Westermark"'
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Autor:
Sara Ullsten, Sara Bohman, Marie E Oskarsson, K Peter R Nilsson, Gunilla T Westermark, Per-Ola Carlsson
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 458-468 (2017)
Islet amyloid and beta cell death in type 2 diabetes are heterogeneous events, where some islets are affected early in the disease process, whereas others remain visibly unaffected. This study investigated the possibility that inter-islet functional
Externí odkaz:
https://doaj.org/article/96a24516c7114072b89f9897f9232a8a
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223456 (2019)
Expression of the Alzheimer's disease associated polypeptide Aβ42 and the human polypeptide hormon islet amyloid polypeptide (hIAPP) and the prohormone precursor (hproIAPP) in neurons of Drosophila melanogaster leads to the formation of protein aggr
Externí odkaz:
https://doaj.org/article/38a30cc3c9d84c3a85089aca68fcffd1
Autor:
Pascal Krotee, Jose A Rodriguez, Michael R Sawaya, Duilio Cascio, Francis E Reyes, Dan Shi, Johan Hattne, Brent L Nannenga, Marie E Oskarsson, Stephan Philipp, Sarah Griner, Lin Jiang, Charles G Glabe, Gunilla T Westermark, Tamir Gonen, David S Eisenberg
Publikováno v:
eLife, Vol 6 (2017)
hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytot
Externí odkaz:
https://doaj.org/article/f0207c5ac18e49debe0019586fe78051
High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.
Autor:
Johan F Paulsson, Johnny Ludvigsson, Annelie Carlsson, Rosaura Casas, Gun Forsander, Sten A Ivarsson, Ingrid Kockum, Åke Lernmark, Claude Marcus, Bengt Lindblad, Gunilla T Westermark
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93053 (2014)
Aims/hypothesisIslet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid.
Externí odkaz:
https://doaj.org/article/fe2016a67c664464a2a995edd28a451e
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79104 (2013)
AA amyloidosis is a systemic disease that develops secondary to chronic inflammatory diseases Macrophages are often found in the vicinity of amyloid deposits and considered to play a role in both formation and degradation of amyloid fibrils. In splee
Externí odkaz:
https://doaj.org/article/aba2a9c7f3a142af927a05dee8a5d147
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6041 (2009)
BACKGROUND:Mouse AA-amyloidosis is a transmissible disease by a prion-like mechanism where amyloid fibrils act by seeding. Synthetic peptides with no amyloid relationship can assemble into amyloid-like fibrils and these may have seeding capacity for
Externí odkaz:
https://doaj.org/article/0fde10554f31490fbfbd8ac0c0e4910b
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3308 (2008)
Spongiform encephalopathies have been reported to be transmitted by blood transfusion even prior to the clinical onset. Experimental AA-amyloidosis shows similarities with prion disease and amyloid-containing organ-extracts can prime a recipient for
Externí odkaz:
https://doaj.org/article/90867bc4b2ff4d53b0447e18335c061e
Autor:
Vincenzo Donadio, Alex Incensi, Giovanni Rizzo, Gunilla T Westermark, Grazia Devigili, Rosa De Micco, Alessandro Tessitore, Dag Nyholm, Sara Parisini, Dag Nyman, Gioacchino Tedeschi, Roberto Eleopra, Martin Ingelsson, Rocco Liguori
Publikováno v:
Brain. 146:1065-1074
Multiple system atrophy (MSA) is characterized by accumulation of phosphorylated α-synuclein (p-syn) as glial cytoplasmic inclusions in the brain and a specific biomarker for this disorder is urgently needed. We aimed at investigating if p-syn can a
Publikováno v:
Frontiers in Molecular Biosciences. 10
Introduction: Parkinson’s disease and type 2 diabetes have both elements of local amyloid depositions in their pathogenesis. In Parkinson’s disease, alpha-synuclein (aSyn) forms insoluble Lewy bodies and Lewy neurites in brain neurons, and in typ