Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Gunilla Olivecrona"'
Autor:
Rakel Nyrén, Henrik Scherman, Jan Axelsson, Chuchun L Chang, Gunilla Olivecrona, Madelene Ericsson
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281705 (2023)
It is known that high-fat diet (HFD) and/or diabetes may influence substrate preferences and energy demands in the heart preceding diabetic cardiomyopathy. They may also induce structural glomerular changes causing diabetic nephropathy. PET/CT has be
Externí odkaz:
https://doaj.org/article/124cc013a28f405287c062f15faad5bc
Autor:
Mingjuan Deng, Elda Kutrolli, Anne Sadewasser, Sven Michel, Masoumeh Motamedi Joibari, Frank Jaschinski, Gunilla Olivecrona, Stefan K. Nilsson, Sander Kersten
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 7, Pp 100237- (2022)
Angiopoietin-like 4 (ANGPTL4) is an important regulator of plasma triglyceride (TG) levels and an attractive pharmacological target for lowering plasma lipids and reducing cardiovascular risk. Here, we aimed to study the efficacy and safety of silenc
Externí odkaz:
https://doaj.org/article/d5cff7e2f7ae4032a5fb717f4f1072c3
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100144- (2022)
LPL is a key player in plasma triglyceride metabolism. Consequently, LPL is regulated by several proteins during synthesis, folding, secretion, and transport to its site of action at the luminal side of capillaries, as well as during the catalytic re
Externí odkaz:
https://doaj.org/article/6263a29f2b284611aaefd00f7a563225
Autor:
Antwi-Boasiako Oteng, PhilipM.M. Ruppert, Lily Boutens, Wieneke Dijk, XantheA.M.H. van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 10, Pp 1741-1754 (2019)
Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric lymphad
Externí odkaz:
https://doaj.org/article/74812b6dc82746ee926df90a90a25a9c
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 783-793 (2019)
Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL. ANGPTL3, much like ANGPTL4, is
Externí odkaz:
https://doaj.org/article/322acdc2f09f4ff28d0375eb5a3550c1
Autor:
Philip M.M. Ruppert, Charlotte C.J.R. Michielsen, Eric J. Hazebroek, Ali Pirayesh, Gunilla Olivecrona, Lydia A. Afman, Sander Kersten
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101033- (2020)
Objective: Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4. Here, we aimed to validate this concept in humans by determining the effect
Externí odkaz:
https://doaj.org/article/632a972fec9f41c5bffa2733af2910aa
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 840-852 (2017)
Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop te
Externí odkaz:
https://doaj.org/article/c5c15204a798475c9c144f183802cfac
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 279-288 (2017)
LPL hydrolyzes triglycerides in plasma lipoproteins. Due to the complex regulation mechanism, it has been difficult to mimic the physiological conditions under which LPL acts in vitro. We demonstrate that isothermal titration calorimetry (ITC), using
Externí odkaz:
https://doaj.org/article/a5870ebc47cf4a07a96a883ffc3a4a01
Autor:
Sophie Valleix, Guglielmo Verona, Noémie Jourde-Chiche, Brigitte Nédelec, P. Patrizia Mangione, Frank Bridoux, Alain Mangé, Ahmet Dogan, Jean-Michel Goujon, Marie Lhomme, Carolane Dauteuille, Michèle Chabert, Riccardo Porcari, Christopher A. Waudby, Annalisa Relini, Philippa J. Talmud, Oleg Kovrov, Gunilla Olivecrona, Monica Stoppini, John Christodoulou, Philip N. Hawkins, Gilles Grateau, Marc Delpech, Anatol Kontush, Julian D. Gillmore, Athina D. Kalopissis, Vittorio Bellotti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpec
Externí odkaz:
https://doaj.org/article/20852c4360d64aac8c27c28e258ec648
Autor:
Roger Savonen, Michaela Hiden, Magnus Hultin, Rudolf Zechner, Sanja Levak-Frank, Gunilla Olivecrona, Thomas Olivecrona
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 3, Pp 588-598 (2015)
To determine the role of LPL for binding of lipoproteins to the vascular endothelium, and for the distribution of lipids from lipoproteins, four lines of induced mutant mice were used. Rat chylomicrons labeled in vivo with [14C]oleic acid (primarily
Externí odkaz:
https://doaj.org/article/22160bd9409a49939c94fa6401fa6967