Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gunilla Linhardt"'
Autor:
Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, Leif G. Carlsson, Benjamin Ulfenborg, Anna Walentinsson, Katarina Rydén-Markinhutha, Margareta Behrendt, Johannes Wikström, Peter Sartipy, Karin Jennbacken, Jane Synnergren
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: After myocardial infarction (MI), the non-infarcted left ventricle (LV) ensures appropriate contractile function of the heart. Metabolic disturbance in this region greatly exacerbates post-MI heart failure (HF) pathology. This study aimed
Externí odkaz:
https://doaj.org/article/714a4f95ddb94bc2881a700d82903f31
Autor:
Leif Carlsson, Jonathan C. Clarke, Christopher Yen, Francine Gregoire, Tamsin Albery, Martin Billger, Ann-Charlotte Egnell, Li-Ming Gan, Karin Jennbacken, Edvin Johansson, Gunilla Linhardt, Sofia Martinsson, Muhammad Waqas Sadiq, Nevin Witman, Qing-Dong Wang, Chien-Hsi Chen, Yu-Ping Wang, Susan Lin, Barry Ticho, Patrick C.H. Hsieh, Kenneth R. Chien, Regina Fritsche-Danielson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 330-346 (2018)
mRNA can direct dose-dependent protein expression in cardiac muscle without genome integration, but to date has not been shown to improve cardiac function in a safe, clinically applicable way. Herein, we report that a purified and optimized mRNA in a
Externí odkaz:
https://doaj.org/article/323a8ccca84c43bd8436f92356b5feeb
Autor:
Kenneth R. Chien, Susan Lin, Patrick C.H. Hsieh, Karin Jennbacken, Muhammad Waqas Sadiq, Francine Gregoire, Yu-Ping Wang, Christopher Y.T. Yen, Jonathan Clarke, Leif Carlsson, Gunilla Linhardt, Qing-Dong Wang, Regina Fritsche-Danielson, Li-Ming Gan, Edvin Johansson, Sofia Martinsson, Martin Billger, Ann-Charlotte Egnell, Nevin Witman, Barry Ticho, Tamsin Albery, Chien-Hsi Chen
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 330-346 (2018)
mRNA can direct dose-dependent protein expression in cardiac muscle without genome integration, but to date has not been shown to improve cardiac function in a safe, clinically applicable way. Herein, we report that a purified and optimized mRNA in a
Publikováno v:
BioMed Research International
BioMed Research International, Vol 2019 (2019)
BioMed Research International, Vol 2019 (2019)
Chemically modified mRNA is a novel, highly efficient, biocompatible modality for therapeutic protein expression that may overcome the challenges and safety concerns with current gene therapy strategies. We explored the efficiency of intradermally in
Autor:
Leif, Carlsson, Jonathan C, Clarke, Christopher, Yen, Francine, Gregoire, Tamsin, Albery, Martin, Billger, Ann-Charlotte, Egnell, Li-Ming, Gan, Karin, Jennbacken, Edvin, Johansson, Gunilla, Linhardt, Sofia, Martinsson, Muhammad Waqas, Sadiq, Nevin, Witman, Qing-Dong, Wang, Chien-Hsi, Chen, Yu-Ping, Wang, Susan, Lin, Barry, Ticho, Patrick C H, Hsieh, Kenneth R, Chien, Regina, Fritsche-Danielson
Publikováno v:
Molecular Therapy. Methods & Clinical Development
mRNA can direct dose-dependent protein expression in cardiac muscle without genome integration, but to date has not been shown to improve cardiac function in a safe, clinically applicable way. Herein, we report that a purified and optimized mRNA in a
Autor:
Annika Åstrand, Monika Sundqvist, Maria Thorstensson, Tomas Fex, Andreas Nordin, Ahlke Hayen, Annika Björe, Ulrik Gran, Christina Olsson, Johan Sundell, Elin Forsström, Emma Lindhardt, Jonas Boström, Gunilla Linhardt, Teresa Collins, Boel Löfberg, Fanyi Jiang, Roine I. Olsson, Ingemar Jacobson, Anna Öhrn, Karolina Aplander, Olle Hidestål, Jonna Gyll
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:706-710
Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and seve
Autor:
Gunilla Linhardt, Leif Carlsson, Håkan Walfridsson, Ann-Christin Nordkam, Lars Frison, Monika Sundqvist, Steen M. Jensen, Anders Berggren, Ole-Gunnar Anfinsen
Publikováno v:
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 17(3)
AIMS: We aimed at examining the acetylcholine-dependent inward-rectifier current (IKAch) as a target for the management of atrial fibrillation (AF). METHODS AND RESULTS: The investigative agents AZD2927 and A7071 concentration-dependently blocked IKA
Autor:
Annika Åstrand, Anna Rönnborg, Emma Lindhardt, Ulrik Gran, Gert Strandlund, Hans Emtenäs, Zhong-Qing Yuan, Jonas Boström, Johan Sundell, Jonna Gyll, Ågot Högberg, Boel Löfberg, Tommy Iliefski, Roine I. Olsson, Birgit Andersson, Olle Hidestål, Tor Svensson, Ingemar Jacobson, Elin Forsström, Frida Persson, Christina Olsson, Annika Björe, Gunilla Linhardt, Öjvind Davidsson, Ola Fjellström, Jesper Malmberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(5)
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure–activity relationships from lead structure C to optimized structure 3y are d
Autor:
Ann-Kristin Nordkam, Malin Florentzson, Leif Carlsson, Annika Åstrand, Ingemar Jacobson, Emma Lindhardt, Gunilla Linhardt, Göran Duker
Publikováno v:
Journal of cardiovascular pharmacology and therapeutics. 18(3)
Objective: To examine the electrophysiological, hemodynamic, and antiarrhythmic effects of the novel antiarrhythmic agent AZ13395438. Methods: The ion channel-blocking potency of AZ13395438 was assessed in Chinese hamster ovary cells stably expressin
Autor:
Charles Antzelevitch, Leif Carlsson, José M. Di Diego, Andrew C. Zygmunt, Gunilla Linhardt, Alexander Burashnikov
Recent development of drugs for the treatment of atrial fibrillation (AF) has focused on atrial selective agents. We examined the atrioventricular differences in sodium channel block of the antiarrhythmic agent AZD1305 in atria and ventricles of anes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e1ed534005adf0f418a2e85a68a42e
https://europepmc.org/articles/PMC2905470/
https://europepmc.org/articles/PMC2905470/