Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Gunhild Von Amsberg"'
Autor:
Nishit Goradia, Stefan Werner, Edukondalu Mullapudi, Sarah Greimeier, Lina Bergmann, Andras Lang, Haydyn Mertens, Aleksandra Węglarz, Simon Sander, Grzegorz Chojnowski, Harriet Wikman, Oliver Ohlenschläger, Gunhild von Amsberg, Klaus Pantel, Matthias Wilmanns
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract While the elucidation of regulatory mechanisms of folded proteins is facilitated due to their amenability to high-resolution structural characterization, investigation of these mechanisms in disordered proteins is more challenging due to the
Externí odkaz:
https://doaj.org/article/5074a5174b144e20817298b0df93967f
Autor:
Sergey A. Dyshlovoy, Wael Y. Mansour, Natalia A. Ramm, Jessica Hauschild, Maxim E. Zhidkov, Malte Kriegs, Alexandra Zielinski, Konstantin Hoffer, Tobias Busenbender, Ksenia A. Glumakova, Pavel V. Spirin, Vladimir S. Prassolov, Derya Tilki, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Fascaplysin is a red cytotoxic pigment with anticancer properties isolated from the marine sponge Fascaplysinopsis sp. Recently, structure–activity relationship analysis reported by our group suggested that selective cytotoxicity of fascap
Externí odkaz:
https://doaj.org/article/df82a4dc141245f18a09fe909aa98ef5
Autor:
Kseniya M. Tabakmakher, Tatyana N. Makarieva, Yuri E. Sabutski, Maxim S. Kokoulin, Alexander S. Menshov, Roman S. Popov, Alla G. Guzii, Larisa K. Shubina, Ekaterina A. Chingizova, Artur R. Chingizov, Ekaterina A. Yurchenko, Sergey N. Fedorov, Boris B. Grebnev, Gunhild von Amsberg, Sergey A. Dyshlovoy, Natalia V. Ivanchina, Pavel S. Dmitrenok
Publikováno v:
Marine Drugs, Vol 22, Iss 9, p 396 (2024)
Stonikacidin A (1), the first representative of a new class of 4-bromopyrrole alkaloids containing an aldonic acid core, was isolated from the marine sponge Lissodendoryx papillosa. The compound is named in honor of Prof. Valentin A. Stonik, who is o
Externí odkaz:
https://doaj.org/article/fe4d2829a6db47ccaa9b4e37dc246dcb
Autor:
Stefanie Zschäbitz, Nadine Biernath, Thomas Hilser, Alexander Höllein, Friedemann Zengerling, Jozefina Cascucelli, Pia Paffenholz, Daniel Seidl, Christoph Lutz, Katrin Schlack, Dorothea Kingreen, Niklas Klümper, Philipp Ivanyi, Gunhild von Amsberg, Hendrik Heers, Florian Roghmann, Robert L. Tauber, Richard Cathomas, Luisa Hofer, Günter Niegisch, Melanie Klee, Roland Ehrenberg, Andreas Hassler, Boris A. Hadaschik, Viktor Grünwald, Christopher Darr
Publikováno v:
European Urology Open Science, Vol 53, Iss , Pp 31-37 (2023)
Background: Treatment options for patients with urothelial cancer (UC) refractory to platinum and immunotherapy are limited and survival is short. Enfortumab vedotin (EV) is a monoclonal anti-NECTIN4 antibody conjugated to monomethyl auristatin. It w
Externí odkaz:
https://doaj.org/article/bd7cfc5ca9a44412a57048e564c5b88c
Autor:
Ekaterina S. Menchinskaya, Sergey A. Dyshlovoy, Simone Venz, Christine Jacobsen, Jessica Hauschild, Tina Rohlfing, Aleksandra S. Silchenko, Sergey A. Avilov, Stefan Balabanov, Carsten Bokemeyer, Dmitry L. Aminin, Gunhild von Amsberg, Friedemann Honecker
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 20 (2023)
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC), treatment is inevitably hampered by the development of drug resistance. Thus, new drugs are urgently needed. We investigated the efficacy, toxicity, a
Externí odkaz:
https://doaj.org/article/ef96dfc1e6784c86a537b7ae846cbe5e
Autor:
Sergey A. Dyshlovoy, Larisa K. Shubina, Tatyana N. Makarieva, Jessica Hauschild, Nadja Strewinsky, Alla G. Guzii, Alexander S. Menshov, Roman S. Popov, Boris B. Grebnev, Tobias Busenbender, Su Jung Oh-Hohenhorst, Tobias Maurer, Derya Tilki, Markus Graefen, Carsten Bokemeyer, Valentin A. Stonik, Gunhild von Amsberg
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Spongian diterpenes are a group of marine natural compounds possessing various biological activities. However, their anticancer activity is still poorly studied and understood. We isolated six spongian diterpenes from the marine sponge Spong
Externí odkaz:
https://doaj.org/article/2ae1644a535b479ca2b9bc182d8cd852
Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
Autor:
Lina Merkens, Verena Sailer, Davor Lessel, Ella Janzen, Sarah Greimeier, Jutta Kirfel, Sven Perner, Klaus Pantel, Stefan Werner, Gunhild von Amsberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continual
Externí odkaz:
https://doaj.org/article/af616c4e41df4e3faad5f2ada80aa9e5
Autor:
Christa Babst, Thomas Amiel, Tobias Maurer, Sophie Knipper, Lukas Lunger, Robert Tauber, Margitta Retz, Kathleen Herkommer, Matthias Eiber, Gunhild von Amsberg, Markus Graefen, Juergen Gschwend, Thomas Steuber, Matthias Heck
Publikováno v:
Asian Journal of Urology, Vol 9, Iss 1, Pp 69-74 (2022)
Objective: Cytoreductive radical prostatectomy (cRP) has been proposed as local treatment option in metastatic hormone-sensitive prostate cancer (mHSPC) to prevent local complications and potentially improve oncological outcomes. In this study, we ex
Externí odkaz:
https://doaj.org/article/977dfb82a9bf40beb8784c23aa58c102
Autor:
Oleg A. Tryapkin, Alexey V. Kantemirov, Sergey A. Dyshlovoy, Vladimir S. Prassolov, Pavel V. Spirin, Gunhild von Amsberg, Maria A. Sidorova, Maxim E. Zhidkov
Publikováno v:
Marine Drugs, Vol 21, Iss 8, p 424 (2023)
Fascaplysin is a marine alkaloid which is considered to be a lead drug candidate due to its diverse and potent biological activity. As an anticancer agent, fascaplysin holds a great potential due to the multiple targets affected by this alkaloid in c
Externí odkaz:
https://doaj.org/article/5a6439f52f024b4ba298586491177fd2
Autor:
Elena V. Leshchenko, Alexandr S. Antonov, Gleb V. Borkunov, Jessica Hauschild, Olesya I. Zhuravleva, Yuliya V. Khudyakova, Alexander S. Menshov, Roman S. Popov, Natalya Yu Kim, Markus Graefen, Carsten Bokemeyer, Gunhild von Amsberg, Anton N. Yurchenko, Sergey A. Dyshlovoy
Publikováno v:
Marine Drugs, Vol 21, Iss 3, p 178 (2023)
Five new β-resorcylic acid derivatives, 14-hydroxyasperentin B (1), β-resoantarctines A-C (3, 5, 6) and 8-dehydro-β-resoantarctine A (4), together with known 14-hydroxyasperentin (5′-hydroxyasperentin) (2), were isolated from the ethyl acetate e
Externí odkaz:
https://doaj.org/article/7a45f1d52cd346fba6773655d5a9d784