Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Gunhild Mari Mælandsmo"'
Autor:
Mads Haugland Haugen, Hedda von der Lippe Gythfeldt, Eivind Valen Egeland, Lisa Svartdal Normann, Abhilash D. Pandya, Lise‐Lotte Vedin, Siri Juell, Ellen Tenstad, Geir Frode Øy, Alexandr Kristian, Elisabetta Marangoni, Therese Sørlie, Knut Steffensen, Gunhild Mari Mælandsmo, Olav Engebraaten
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2041-2055 (2023)
Liver X receptors (LXRs) are nuclear transcription factors important in the regulation of cholesterol transport, and glucose and fatty acid metabolism. The antiproliferative role of LXRs has been studied in a variety of malignancies and may represent
Externí odkaz:
https://doaj.org/article/f082ee37ad4f4724ba7aa48e46c2a756
Autor:
Salim Ghannoum, Damiano Fantini, Muhammad Zahoor, Veronika Reiterer, Santosh Phuyal, Waldir Leoncio Netto, Øystein Sørensen, Arvind Iyer, Debarka Sengupta, Lina Prasmickaite, Gunhild Mari Mælandsmo, Alvaro Köhn-Luque, Hesso Farhan
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1010995 (2023)
Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravas
Externí odkaz:
https://doaj.org/article/b8118049e62a414e937e60e0e8721f71
Autor:
Marta Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad, Vivi Ann Flørenes, Lina Prasmickaite, Gunhild Mari Mælandsmo, Kotryna Seip
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype
Externí odkaz:
https://doaj.org/article/9ed4fda92ae4471a8ea70e8ac8bab465
Autor:
Solveig Pettersen, Geir Frode Øy, Eivind Valen Egeland, Siri Juell, Olav Engebråten, Gunhild Mari Mælandsmo, Lina Prasmickaite
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Assessment of drug sensitivity in tumor tissue ex vivo may significantly contribute to functional diagnostics to guide personalized treatment of cancer. Tumor organoid- and explant-cultures have become attractive tools towards this goal, although cul
Externí odkaz:
https://doaj.org/article/6ce42576d2d34e0387fa3dbd48539e9c
Autor:
Lisa Svartdal Normann, Mads Haugland Haugen, Vesa Hongisto, Miriam Ragle Aure, Suvi-Katri Leivonen, Vessela N Kristensen, Andliena Tahiri, Olav Engebraaten, Kristine Kleivi Sahlberg, Gunhild Mari Mælandsmo
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0280507 (2023)
Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive subtype of this disease. Targeted treatment has improved outcome, but there is still a need for new therapeutic strategies as some patients respond poorly to tre
Externí odkaz:
https://doaj.org/article/a267b2c834e74bde9dda62efe4aa7af4
Autor:
Sigurdur Trausti Karvelsson, Qiong Wang, Bylgja Hilmarsdottir, Arnar Sigurdsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo, Skarphedinn Halldorsson, Steinn Gudmundsson, Ottar Rolfsson
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic p
Externí odkaz:
https://doaj.org/article/cdfa07e4bd6d4ad0a6994536dab48cac
Autor:
Lisa Svartdal Normann, Miriam Ragle Aure, Suvi-Katri Leivonen, Mads Haugland Haugen, Vesa Hongisto, Vessela N. Kristensen, Gunhild Mari Mælandsmo, Kristine Kleivi Sahlberg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract HER2-positive (HER2 +) breast cancer patients that do not respond to targeted treatment have a poor prognosis. The effects of targeted treatment on endogenous microRNA (miRNA) expression levels are unclear. We report that responsive HER2 + b
Externí odkaz:
https://doaj.org/article/0b40ee361d9441319955d2b6754721b1
Autor:
Vegar Johansen Dagenborg, Serena Elizabeth Marshall, Krzysztof Grzyb, Åsmund Avdem Fretland, Marius Lund-Iversen, Gunhild Mari Mælandsmo, Anne Hansen Ree, Bjørn Edwin, Sheraz Yaqub, Kjersti Flatmark
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundThe subtype, density and location of tumor infiltrating T-cells are being explored as prognostic and predictive biomarkers in primary colorectal cancer (pCRC) and colorectal liver metastases (CLM). Very limited data exist comparing findings
Externí odkaz:
https://doaj.org/article/04dd59c65dcb4a6c832313b8b1b59e75
Autor:
Vivi Ann Flørenes, Karine Flem-Karlsen, Erin McFadden, Inger Riise Bergheim, Vigdis Nygaard, Vegard Nygård, Inger Nina Farstad, Geir Frode Øy, Elisabeth Emilsen, Karianne Giller-Fleten, Anne Hansen Ree, Kjersti Flatmark, Hans Petter Gullestad, Robert Hermann, Truls Ryder, Patrik Wernhoff, Gunhild Mari Mælandsmo
Publikováno v:
Translational Oncology, Vol 12, Iss 7, Pp 951-958 (2019)
Although clinical management of melanoma has changed considerably in recent years, intrinsic treatment resistance remains a severe problem and strategies to design personal treatment regimens are highly warranted. We have applied a three-dimensional
Externí odkaz:
https://doaj.org/article/5e33a627a4a3411eb74675f0d94b0c59
Autor:
Karine Flem-Karlsen, Marta Nyakas, Inger Nina Farstad, Erin McFadden, Patrik Wernhoff, Kari Dolven Jacobsen, Vivi Ann Flørenes, Gunhild Mari Mælandsmo
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227187 (2020)
Receptor tyrosine kinase AXL is a one-pass transmembrane protein upregulated in cancers and associated with lower survival and therapy resistance. AXL can be cleaved by the A Disintegrin and Metalloproteinases (ADAM)10 and ADAM17, yielding a soluble
Externí odkaz:
https://doaj.org/article/6d25b75e3c324aac915021869a7e4931