Výsledky vyhledávání - "Gunhild Layer"

Akademický článek

Trapping the substrate radical of heme synthase AhbD

Autor: Lorenz Heidinger, Isabelle Fix, Thorsten Friedrich, Gunhild Layer

Publikováno v: Frontiers in Chemistry, Vol 12 (2024)

The heme synthase AhbD catalyzes the last step of the siroheme-dependent heme biosynthesis pathway, which is operative in archaea and sulfate-reducing bacteria. The AhbD-catalyzed reaction consists of the oxidative decarboxylation of two propionate s

Externí odkaz: https://doaj.org/article/a0c30daf8b294d5a838ad051373c5bff

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Akademický článek

The Radical SAM Heme Synthase AhbD from Methanosarcina barkeri Contains Two Auxiliary [4Fe-4S] Clusters

Autor: Isabelle Fix, Lorenz Heidinger, Thorsten Friedrich, Gunhild Layer

Publikováno v: Biomolecules, Vol 13, Iss 8, p 1268 (2023)

In archaea and sulfate-reducing bacteria, heme is synthesized via the siroheme-dependent pathway. The last step of this route is catalyzed by the Radical SAM enzyme AhbD and consists of the conversion of iron-coproporphyrin III into heme. AhbD belong

Externí odkaz: https://doaj.org/article/6fddff3a6f64407196ee40e14be860af

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Akademický článek

Identification of a unique Radical SAM methyltransferase required for the sp3-C-methylation of an arginine residue of methyl-coenzyme M reductase

Autor: Darja Deobald, Lorenz Adrian, Christian Schöne, Michael Rother, Gunhild Layer

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Abstract The biological formation of methane (methanogenesis) is a globally important process, which is exploited in biogas technology, but also contributes to global warming through the release of a potent greenhouse gas into the atmosphere. The las

Externí odkaz: https://doaj.org/article/c37f66b8b000441589257bda3f49c408

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Akademický článek

The Alternative Route to Heme in the Methanogenic Archaeon Methanosarcina barkeri

Autor: Melanie Kühner, Kristin Haufschildt, Alexander Neumann, Sonja Storbeck, Judith Streif, Gunhild Layer

Publikováno v: Archaea, Vol 2014 (2014)

In living organisms heme is formed from the common precursor uroporphyrinogen III by either one of two substantially different pathways. In contrast to eukaryotes and most bacteria which employ the so-called “classical” heme biosynthesis pathway,

Externí odkaz: https://doaj.org/article/bf3fee225137438b924c6e8eb1c8cf15

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Akademický článek

A Novel Pathway for the Biosynthesis of Heme in Archaea: Genome-Based Bioinformatic Predictions and Experimental Evidence

Autor: Sonja Storbeck, Sarah Rolfes, Evelyne Raux-Deery, Martin J. Warren, Dieter Jahn, Gunhild Layer

Publikováno v: Archaea, Vol 2010 (2010)

Heme is an essential prosthetic group for many proteins involved in fundamental biological processes in all three domains of life. In Eukaryota and Bacteria heme is formed via a conserved and well-studied biosynthetic pathway. Surprisingly, in Archae

Externí odkaz: https://doaj.org/article/a0f0cda8429440dbb0b3068346e8470c

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