Výsledky vyhledávání - "Gunel Ayyubova"

Akademický článek

Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus

Autor: Gunel Ayyubova, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu, Sahithi Attaluri, Yogish Somayaji, Bing Shuai, Shama Rao, Goutham Shankar, Ashok K. Shetty

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-26 (2023)

Abstract Extracellular vesicles (EVs) released by human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSCs) are enriched with miRNAs and proteins capable of mediating robust antiinflammatory activity. The lack of tumorigenic and immu

Externí odkaz: https://doaj.org/article/babb73ba873d43e5aaae3a4f6631489f

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Akademický článek

Beneficial versus Detrimental Effects of Complement–Microglial Interactions in Alzheimer’s Disease

Autor: Gunel Ayyubova, Nadeem Fazal

Publikováno v: Brain Sciences, Vol 14, Iss 5, p 434 (2024)

Research indicates that brain-region-specific synapse loss and dysfunction are early hallmarks and stronger neurobiological correlates of cognitive decline in Alzheimer’s disease (AD) than amyloid plaque and neurofibrillary tangle counts or neurona

Externí odkaz: https://doaj.org/article/f15c2c3b1f6542688ec0f63ae1b58407

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Akademický článek

The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders

Autor: Gunel Ayyubova, Sergiy G. Gychka, Sofia I. Nikolaienko, Fada A. Alghenaim, Tadahisa Teramoto, Nataliia V. Shults, Yuichiro J. Suzuki

Publikováno v: Life, Vol 14, Iss 2, p 279 (2024)

Neurological disorders have been reported in a large number of coronavirus disease 2019 (COVID-19) patients, suggesting that this disease may have long-term adverse neurological consequences. COVID-19 occurs from infection by a positive-sense single-

Externí odkaz: https://doaj.org/article/c4daae26180c4b03be3a612b138daa68

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TREM2 signalling as a multifaceted player in brain homoeostasis and a potential target for Alzheimer's disease treatment

Autor: Gunel Ayyubova

Publikováno v: European Journal of Neuroscience. 57:718-733

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6796e611ea7677705547e10fcec19f8a
https://doi.org/10.1111/ejn.15914

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Dysfunctional microglia and tau pathology in Alzheimer’s disease

Autor: Gunel Ayyubova

Publikováno v: Reviews in the Neurosciences. 34:443-458

Extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in Alzheimer’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc65131ed763c224ee1e35b25731e15
https://doi.org/10.1515/revneuro-2022-0087

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Apoe4 Is A Risk Factor And Potential Therapeutic Target For Alzheimer's Disease

Autor: Gunel Ayyubova

Publikováno v: CNS & Neurological Disorders - Drug Targets. 22

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease, the main pathological hallmark of which is the loss of neurons, resulting in cognitive and memory impairments. Sporadic late-onset AD is the prevalent form of the disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c26de091647e345349f4718d6e559c2
https://doi.org/10.2174/1871527322666230303114425

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