Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Gunde Egeskov Jensen"'
1
QSAR models for P450 (2D6) substrate activity
Autor: Jay Russell Niemelä, Gunde Egeskov Jensen, Eva Bay Wedebye, Tine Ringsted, Nikolai Georgiev Nikolov
Publikováno v: SAR and QSAR in Environmental Research. 20:309-325
Human Cytochrome P450 (CYP) is a large group of enzymes that possess an essential function in metabolising different exogenous and endogenous compounds. Humans have more than 50 different genes encoding CYP enzymes, among these a gene encoding for th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d48e91bd5f46b124ed1f9a7eab823907
https://doi.org/10.1080/10629360902949195
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2
ERYTHROCYTE GLUTATHIONE PEROXIDASE DEFICIENCY IN MULTIPLE SCLEROSIS
Autor: Jørgen Clausen, Gunde Egeskov Jensen, V. K. S. Shukla
Publikováno v: Acta Neurologica Scandinavica. 56:542-550
The present study demonstrates a significant decrease in glutathione peroxidase activity in erythrocytes of 24 patients with multiple sclerosis (MS) when the data are expressed as enzymic units per mg hemoglobin and compared to data from normal contr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99becb71c9c4d1ec7e261db27766f902
https://doi.org/10.1111/j.1600-0404.1977.tb01459.x
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3
Screening of 397 Chemicals and Development of a Quantitative Structure−Activity Relationship Model for Androgen Receptor Antagonism
Autor: Eva Bay Wedebye, Annemarie Vinggaard, Jay Russell Niemelä, Gunde Egeskov Jensen
Publikováno v: Chemical Research in Toxicology. 21:813-823
We have screened 397 chemicals for human androgen receptor (AR) antagonism by a sensitive reporter gene assay to generate data for the development of a quantitative structure-activity relationship (QSAR) model. A total of 523 chemicals comprising dat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2a4c0f04c44412006bfed046a395e7
https://doi.org/10.1021/tx7002382
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4
QSAR Model for Androgen Receptor Antagonism - Data from CHO Cell Reporter Gene Assays
Autor: Jay Russel, Nikolai Georgiev Nikolov, Karin Dreisig, Niemelä, Anne Marie Vinggaard, Gunde Egeskov Jensen
Publikováno v: Jensen, G E, Nikolov, N G, Sørensen, K D, Vinggaard, A M & Niemelä, J R 2012, ' QSAR Model for Androgen Receptor Antagonism-Data from CHO Cell Reporter Gene Assays ' Journal of Steroids & Hormonal Science . https://doi.org/10.4172/2157-7536.S2-006
For the development of QSAR models for Androgen Receptor (AR) antagonism, a training set based on reporter gene data from Chinese hamster ovary (CHO) cells was constructed. The training set is composed of data from the literature as well as new data
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddec64f7fde70f43a76f4df9e5127b37
https://doi.org/10.4172/2157-7536.s2-006
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5
QSAR models for anti-androgenic effect--a preliminary study
Autor: Gunde Egeskov Jensen, Tine Ringsted, Jay Russell Niemelä, Nikolai Georgiev Nikolov, Eva Bay Wedebye
Publikováno v: SAR and QSAR in environmental research. 22(1-2)
Three modelling systems (MultiCase®, LeadScope® and MDL® QSAR) were used for construction of androgenic receptor antagonist models. There were 923-942 chemicals in the training sets. The models were cross-validated (leave-groups-out) with concorda
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ff54027387e0c6d4d84ea8e19f9cfe
https://pubmed.ncbi.nlm.nih.gov/21391140
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7
Glutathione Peroxidase Activity in Vitamin E and Essential Fatty Acid-Deficient Rats
Autor: Gunde Egeskov Jensen, Jørgen Clausen
Publikováno v: Annals of Nutrition and Metabolism. 25:27-37
Gluthathione peroxidase (EC 1.11.1.9, GSHPx) activity was measured in whole liver, in hepatic cytosol and in whole mitochondria from normal rats and from rats subjected to experimentally induced vitamin e and/or essential fatty acid (EFA) deficiency.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3307fdb119ca3bd4ccb7a8f75415413a
https://doi.org/10.1159/000176476
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9
Clinical, Social and Biochemical Studies on Batten’s Syndrome, alias Spielmeyer-Vogt or Stengel’s Syndrome
Autor: Grzegorz Konat, Gunde Egeskov Jensen, Jørgen Clausen, Johannes C. Melchior
Publikováno v: European Neurology. 15:203-211
The clinical and biochemical data on 13 patients with Batten's syndrome are described. Clinically the disease was characterized by progressive maental and somatic deterioration. Initially, vision loss was found between the ages 4 and 8 years. This wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3b9aa9b84b155cac3f1f15662842f8
https://doi.org/10.1159/000114834
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10
Leucocyte glutathione peroxidase activity and selenium level in multiple sclerosis
Autor: Jørgen Clausen, Gunde Egeskov Jensen, Gunnar Gissel-Nielsen
Publikováno v: Journal of the Neurological Sciences. 48:61-67
In continuation of our previous studies, which demonstrated a decreased glutathione peroxidase (GSH-Px) activity of erythrocytes from multiple sclerosis (MS) patients the activity of some enzymes regulating the peroxide level (GSH-PX and glutathione
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced75dbbe8515edc8d2652472c430a06
https://doi.org/10.1016/0022-510x(80)90150-1
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