Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Gunawardana Indrani W"'
Autor:
Darin Smith, Guy Vigers, Sumeet Rana, Michael Burkard, April Cox, Robert D. Groneberg, Ryan J. Watts, Robert Kirk Delisle, Tony Pisal Tang, Andrew T. Metcalf, Kelly Regal, Susan P. Rhodes, Mary K. Geck Do, Karin D. Brown, Joseph P. Lyssikatos, Douglas Mccord Sammond, Matthew Volgraf, Albion D. Wright, Gunawardana Indrani W, Kimberly Scearce-Levie, Jennifer N. Otten, Allen A. Thomas, Michael Siu, Hans E. Purkey, Kevin W. Hunt, Xingrong Liu, Darrin Dutcher
Publikováno v:
Journal of Medicinal Chemistry. 57:878-902
In an attempt to increase selectivity vs Cathepsin D (CatD) in our BACE1 program, a series of 1,3,4,4a,10,10a-hexahydropyrano[4,3-b]chromene analogues was developed. Three different Asp-binding moieties were examined: spirocyclic acyl guanidines, ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936cb574f0793c10f3925c44b16b4302
https://doi.org/10.1021/jm401635n
https://doi.org/10.1021/jm401635n
Autor:
Barb Brandhuber, Stephen S. Gonzales, Guy Vigers, Kevin Ronald Condroski, Jed Pheneger, Patrice Lee, Allen A. Thomas, Y. Le Huerou, J. De Meese, Robin Pedersen, Jie Lin, Todd Romoff, Greg Poch, Christine Lemieux, Gunawardana Indrani W, Boyd Steven A, May Han, Francis X. Sullivan, Darin Smith, Bryan Bernat, Tomas Kaplan, Walter E. DeWolf, Josh Ballard, S. Kirk Wright, Solly Weiler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2206-2210
Tumor cells extensively utilize the pentose phosphate pathway for the synthesis of ribose. Transketolase is a key enzyme in this pathway and has been suggested as a target for inhibition in the treatment of cancer. In a pharmacodynamic study, nude mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b4fdd4c86f1034270a73ea8e265e24
https://doi.org/10.1016/j.bmcl.2007.11.101
https://doi.org/10.1016/j.bmcl.2007.11.101
Autor:
Allen A. Thomas, Todd Romoff, Laura Hayter, Jed Pheneger, Jason De Meese, Patrice Lee, Boyd Steven A, S. Kirk Wright, Christine Lemieux, Gunawardana Indrani W, Steven S. Gonzales, Walter E. DeWolf, Francis X. Sullivan, Yvan Le Huerou, Jie Lin, Gregory K. Poch, May Han, Tomas Kaplan, Solly Weiler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:505-508
Transketolase, a key enzyme in the pentose phosphate pathway, has been suggested as a target for inhibition in the treatment of cancer. Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c52fc62ae58a00ee42cd9c0ad1223c8
https://doi.org/10.1016/j.bmcl.2007.11.100
https://doi.org/10.1016/j.bmcl.2007.11.100
Publikováno v:
Journal of Heterocyclic Chemistry. 45:91-96
Treatment of 3,5-dibromo- or 3,5-dichloro-pyridine-4-carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4-bromo- or 4-chloro-thieno[2,3-c]pyridine-2-carboxylate 4 in good yields. Oxidation of the thie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4160de091ff0133815d62d1610c3fac5
https://doi.org/10.1002/jhet.5570450106
https://doi.org/10.1002/jhet.5570450106
Autor:
Hunt, Kevin W., Cook, Adam W., Watts, Ryan J., Clark, Christopher T., Vigers, Guy, Smith, Darin, Metcalf, Andrew T., Gunawardana, Indrani W., Burkard, Michael, Cox, April A., Geck Do, Mary K., Dutcher, Darrin, Thomas, Allen A., Rana, Sumeet, Kallan, Nicholas C., DeLisle, Robert K., Rizzi, James P., Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P., Marlow, Allison, Liu, Xingrong, Tang, Tony P.
Publikováno v:
Journal of Medicinal Chemistry; 20240101, Issue: Preprints
Autor:
Akiyo Claiborne, Gang Liu, David Frost, Ken Jarvis, Jeffery D. Alder, Thomas W. von Geldern, and Qun Li, Joy Bauch, Laura Gehrke, William J. Chiou, Gunawardana Indrani W, Saul H. Rosenberg, Andrew Tasker, Jae Hwan-Soo, Bruce G. Szczepankiewicz, R. Bruce Credo, Yu Hua Hui, Michael A. Nukkala, Nicolette A. Zielinski, J. Ruth Wu-Wong, Stephen L. Gwaltney, Karl W. Mollison
Publikováno v:
Journal of Medicinal Chemistry. 44:4416-4430
During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af95cb1724b235389be978fd3f83efc
https://doi.org/10.1021/jm010231w
https://doi.org/10.1021/jm010231w
Autor:
Andrew T. Metcalf, Allison Marlow, Robert Kirk Delisle, Ryan J. Watts, April Cox, Christopher T. Clark, Kelly Regal, Douglas Mccord Sammond, Kevin W. Hunt, Mary K. Geck Do, Guy Vigers, Sumeet Rana, James P. Rizzi, Tony Pisal Tang, Allen A. Thomas, Nicholas C. Kallan, Xingrong Liu, Adam W. Cook, Michael Siu, Darin Smith, Hans E. Purkey, Gunawardana Indrani W, Darrin Dutcher, Joseph P. Lyssikatos, Michael Burkard, Robert D. Groneberg
Publikováno v:
Journal of medicinal chemistry. 56(8)
A hallmark of Alzheimer's disease is the brain deposition of amyloid beta (Aβ), a peptide of 36-43 amino acids that is likely a primary driver of neurodegeneration. Aβ is produced by the sequential cleavage of APP by BACE1 and γ-secretase; therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4993538cb48c85f01cf3f31dd966b90a
https://pubmed.ncbi.nlm.nih.gov/23537249
https://pubmed.ncbi.nlm.nih.gov/23537249
Autor:
Jay R. Luly, Gunawardana Indrani W, Benjamin C. Lane, Gin C. Hsieh, Karl W. Mollison, Megumi Kawai
Publikováno v:
ChemInform. 29
Ascomycin 2, a close analogue of the immunosuppressant FK506 1, was modified to incorporate a hydroxyl group at the C-33 position. This increased the aqueous solubility of ascomycin by a hundred-fold at pH 7.4 and by approximately 300-fold at pH 6.5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2fdff8ea19324da24c298973be127f1
https://doi.org/10.1002/chin.199833294
https://doi.org/10.1002/chin.199833294
Publikováno v:
ChemInform. 39
Treatment of 3,5-dibromo- or 3,5-dichloro-pyridine-4-carboxaldehyde 2 with one equivalent of methyl thioglycolate, followed by exposure to base, provided 4-bromo- or 4-chloro-thieno[2,3-c]pyridine-2-carboxylate 4 in good yields. Oxidation of the thie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ad418caccd1347a80340440fb1516d
https://doi.org/10.1002/chin.200819143
https://doi.org/10.1002/chin.200819143
Autor:
Francis X. Sullivan, J. De Meese, Tomas Kaplan, Steven S. Gonzales, Josh Ballard, Solly Weiler, Joseph P. Lyssikatos, Thomas Daniel Aicher, Christine Lemieux, S. Kirk Wright, Barb Brandhuber, Gunawardana Indrani W, Allen A. Thomas, Todd Romoff, May Han, Kevin Ronald Condroski, Guy Vigers, Darin Smith, Bryan Bernat, Boyd Steven A, Y. Le Huerou, Walter E. DeWolf
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(2)
Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation. Most thiamine antagonists have a permanent positive charge on the B-ring, and it has been suggested that this charge is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f66bd76203361de76da1e4e8b7019ed
https://pubmed.ncbi.nlm.nih.gov/18182286
https://pubmed.ncbi.nlm.nih.gov/18182286