Stereoselective Olefination with Sterically Demanding Julia-Kocienski Reagents: Total Synthesis of Oxo-prothracarcin, Oxo-tomaymycin, and Boseongazepine B

Autor: Zigma̅rs Leitis, Guna Sakaine, Artis Kine̅ns, Gints Smits

Publikováno v: ACS omega. 7(34)

Total syntheses of three pyrrolo[1,4]benzodiazepine anticancer antibiotic family members oxo-prothracarcin, oxo-tomaymycin, and boseongazepine B are described. The total syntheses feature late-stage stereoselective olefination employing modified Juli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598b08963af0ae61061d38ea4ce7efb9
https://pubmed.ncbi.nlm.nih.gov/36061714

Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds

Autor: Irene G. Salado, An Matheeussen, Guna Sakaine, Pieter Van der Veken, Tiffany van der Meer, Rob Leurs, Sheraz Gul, Payman Sadek, A.K. Singh, Marco Siderius, David G. Brown, Koen Augustyns, Louis Maes, Geert Jan Sterk, Carlos Moreno-Cinos

Publikováno v: Journal of medicinal chemistry, 63(7), 3485-3507. American Chemical Society
Journal of medicinal chemistry
Salado, I G, Singh, A K, Moreno-Cinos, C, Sakaine, G, Siderius, M, Van der Veken, P, Matheeussen, A, van der Meer, T, Sadek, P, Gul, S, Maes, L, Sterk, G J, Leurs, R, Brown, D & Augustyns, K 2020, ' Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds ', Journal of medicinal chemistry, vol. 63, no. 7, pp. 3485-3507 . https://doi.org/10.1021/acs.jmedchem.9b00985

Human African trypanosomiasis is causing thousands of deaths every year in the rural areas of Africa. In this manuscript we describe the optimization of a family of phtalazinone derivatives. Phosphodiesterases have emerged as attractive molecular tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6d9c3727dbeba63b6e0ceffd248450
http://www.scopus.com/inward/record.url?scp=85083085396&partnerID=8YFLogxK

The first total synthesis of usabamycins a and C

Autor: Gints Smits, Ronalds Zemribo, Guna Sakaine

Publikováno v: Tetrahedron Letters. 58:2426-2428

The first total synthesis of usabamycins A and C from inexpensive and readily available amino acids – homoalanine and glycine and featuring a stereoselective Ireland-Claisen rearrangement as well as a novel 7-membered ring formation reaction is des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8e567f9ed9f7f18b2ddb38ed2a138e9
https://doi.org/10.1016/j.tetlet.2017.05.020

Late stage Fe(CO)5 promoted double bond migration: total synthesis of limazepines C and D

Autor: Gints Smits, Ronalds Zemribo, Guna Sakaine

Publikováno v: Tetrahedron Letters. 56:4767-4769

The first total syntheses of limazepines C and D were accomplished from inexpensive and readily available starting materials using an iron pentacarbonyl promoted allylamide–enamide double bond migration as a key step. The obtained limazepine C was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090f62a617f5c8960d911b3e39cf70b1
https://doi.org/10.1016/j.tetlet.2015.06.051