HEK-Omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing

Autor: Gurazada, Sai Guna Ranjan, Kennedy, Hannah M., Braatz, Richard D., Mehrman, Steven J., Polson, Shawn W., Rombel, Irene T.

Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, this requires robust, scalable, industrialized production to meet demand and provide affordable p

Externí odkaz: http://arxiv.org/abs/2408.13374

The Llama 3 Herd of Models

Autor: Grattafiori, Aaron, Dubey, Abhimanyu, Jauhri, Abhinav, Pandey, Abhinav, Kadian, Abhishek, Al-Dahle, Ahmad, Letman, Aiesha, Mathur, Akhil, Schelten, Alan, Vaughan, Alex, Yang, Amy, Fan, Angela, Goyal, Anirudh, Hartshorn, Anthony, Yang, Aobo, Mitra, Archi, Sravankumar, Archie, Korenev, Artem, Hinsvark, Arthur, Rao, Arun, Zhang, Aston, Rodriguez, Aurelien, Gregerson, Austen, Spataru, Ava, Roziere, Baptiste, Biron, Bethany, Tang, Binh, Chern, Bobbie, Caucheteux, Charlotte, Nayak, Chaya, Bi, Chloe, Marra, Chris, McConnell, Chris, Keller, Christian, Touret, Christophe, Wu, Chunyang, Wong, Corinne, Ferrer, Cristian Canton, Nikolaidis, Cyrus, Allonsius, Damien, Song, Daniel, Pintz, Danielle, Livshits, Danny, Wyatt, Danny, Esiobu, David, Choudhary, Dhruv, Mahajan, Dhruv, Garcia-Olano, Diego, Perino, Diego, Hupkes, Dieuwke, Lakomkin, Egor, AlBadawy, Ehab, Lobanova, Elina, Dinan, Emily, Smith, Eric Michael, Radenovic, Filip, Guzmán, Francisco, Zhang, Frank, Synnaeve, Gabriel, Lee, Gabrielle, Anderson, Georgia Lewis, Thattai, Govind, Nail, Graeme, Mialon, Gregoire, Pang, Guan, Cucurell, Guillem, Nguyen, Hailey, Korevaar, Hannah, Xu, Hu, Touvron, Hugo, Zarov, Iliyan, Ibarra, Imanol Arrieta, Kloumann, Isabel, Misra, Ishan, Evtimov, Ivan, Zhang, Jack, Copet, Jade, Lee, Jaewon, Geffert, Jan, Vranes, Jana, Park, Jason, Mahadeokar, Jay, Shah, Jeet, van der Linde, Jelmer, Billock, Jennifer, Hong, Jenny, Lee, Jenya, Fu, Jeremy, Chi, Jianfeng, Huang, Jianyu, Liu, Jiawen, Wang, Jie, Yu, Jiecao, Bitton, Joanna, Spisak, Joe, Park, Jongsoo, Rocca, Joseph, Johnstun, Joshua, Saxe, Joshua, Jia, Junteng, Alwala, Kalyan Vasuden, Prasad, Karthik, Upasani, Kartikeya, Plawiak, Kate, Li, Ke, Heafield, Kenneth, Stone, Kevin, El-Arini, Khalid, Iyer, Krithika, Malik, Kshitiz, Chiu, Kuenley, Bhalla, Kunal, Lakhotia, Kushal, Rantala-Yeary, Lauren, van der Maaten, Laurens, Chen, Lawrence, Tan, Liang, Jenkins, Liz, Martin, Louis, Madaan, Lovish, Malo, Lubo, Blecher, Lukas, Landzaat, Lukas, de Oliveira, Luke, Muzzi, Madeline, Pasupuleti, Mahesh, Singh, Mannat, Paluri, Manohar, Kardas, Marcin, Tsimpoukelli, Maria, Oldham, Mathew, Rita, Mathieu, Pavlova, Maya, Kambadur, Melanie, Lewis, Mike, Si, Min, Singh, Mitesh Kumar, Hassan, Mona, Goyal, Naman, Torabi, Narjes, Bashlykov, Nikolay, Bogoychev, Nikolay, Chatterji, Niladri, Zhang, Ning, Duchenne, Olivier, Çelebi, Onur, Alrassy, Patrick, Zhang, Pengchuan, Li, Pengwei, Vasic, Petar, Weng, Peter, Bhargava, Prajjwal, Dubal, Pratik, Krishnan, Praveen, Koura, Punit Singh, Xu, Puxin, He, Qing, Dong, Qingxiao, Srinivasan, Ragavan, Ganapathy, Raj, Calderer, Ramon, Cabral, Ricardo Silveira, Stojnic, Robert, Raileanu, Roberta, Maheswari, Rohan, Girdhar, Rohit, Patel, Rohit, Sauvestre, Romain, Polidoro, Ronnie, Sumbaly, Roshan, Taylor, Ross, Silva, Ruan, Hou, Rui, Wang, Rui, Hosseini, Saghar, Chennabasappa, Sahana, Singh, Sanjay, Bell, Sean, Kim, Seohyun Sonia, Edunov, Sergey, Nie, Shaoliang, Narang, Sharan, Raparthy, Sharath, Shen, Sheng, Wan, Shengye, Bhosale, Shruti, Zhang, Shun, Vandenhende, Simon, Batra, Soumya, Whitman, Spencer, Sootla, Sten, Collot, Stephane, Gururangan, Suchin, Borodinsky, Sydney, Herman, Tamar, Fowler, Tara, Sheasha, Tarek, Georgiou, Thomas, Scialom, Thomas, Speckbacher, Tobias, Mihaylov, Todor, Xiao, Tong, Karn, Ujjwal, Goswami, Vedanuj, Gupta, Vibhor, Ramanathan, Vignesh, Kerkez, Viktor, Gonguet, Vincent, Do, Virginie, Vogeti, Vish, Albiero, Vítor, Petrovic, Vladan, Chu, Weiwei, Xiong, Wenhan, Fu, Wenyin, Meers, Whitney, Martinet, Xavier, Wang, Xiaodong, Wang, Xiaofang, Tan, Xiaoqing Ellen, Xia, Xide, Xie, Xinfeng, Jia, Xuchao, Wang, Xuewei, Goldschlag, Yaelle, Gaur, Yashesh, Babaei, Yasmine, Wen, Yi, Song, Yiwen, Zhang, Yuchen, Li, Yue, Mao, Yuning, Coudert, Zacharie Delpierre, Yan, Zheng, Chen, Zhengxing, Papakipos, Zoe, Singh, Aaditya, Srivastava, Aayushi, Jain, Abha, Kelsey, Adam, Shajnfeld, Adam, Gangidi, Adithya, Victoria, Adolfo, Goldstand, Ahuva, Menon, Ajay, Sharma, Ajay, Boesenberg, Alex, Baevski, Alexei, Feinstein, Allie, Kallet, Amanda, Sangani, Amit, Teo, Amos, Yunus, Anam, Lupu, Andrei, Alvarado, Andres, Caples, Andrew, Gu, Andrew, Ho, Andrew, Poulton, Andrew, Ryan, Andrew, Ramchandani, Ankit, Dong, Annie, Franco, Annie, Goyal, Anuj, Saraf, Aparajita, Chowdhury, Arkabandhu, Gabriel, Ashley, Bharambe, Ashwin, Eisenman, Assaf, Yazdan, Azadeh, James, Beau, Maurer, Ben, Leonhardi, Benjamin, Huang, Bernie, Loyd, Beth, De Paola, Beto, Paranjape, Bhargavi, Liu, Bing, Wu, Bo, Ni, Boyu, Hancock, Braden, Wasti, Bram, Spence, Brandon, Stojkovic, Brani, Gamido, Brian, Montalvo, Britt, Parker, Carl, Burton, Carly, Mejia, Catalina, Liu, Ce, Wang, Changhan, Kim, Changkyu, Zhou, Chao, Hu, Chester, Chu, Ching-Hsiang, Cai, Chris, Tindal, Chris, Feichtenhofer, Christoph, Gao, Cynthia, Civin, Damon, Beaty, Dana, Kreymer, Daniel, Li, Daniel, Adkins, David, Xu, David, Testuggine, Davide, David, Delia, Parikh, Devi, Liskovich, Diana, Foss, Didem, Wang, Dingkang, Le, Duc, Holland, Dustin, Dowling, Edward, Jamil, Eissa, Montgomery, Elaine, Presani, Eleonora, Hahn, Emily, Wood, Emily, Le, Eric-Tuan, Brinkman, Erik, Arcaute, Esteban, Dunbar, Evan, Smothers, Evan, Sun, Fei, Kreuk, Felix, Tian, Feng, Kokkinos, Filippos, Ozgenel, Firat, Caggioni, Francesco, Kanayet, Frank, Seide, Frank, Florez, Gabriela Medina, Schwarz, Gabriella, Badeer, Gada, Swee, Georgia, Halpern, Gil, Herman, Grant, Sizov, Grigory, Guangyi, Zhang, Lakshminarayanan, Guna, Inan, Hakan, Shojanazeri, Hamid, Zou, Han, Wang, Hannah, Zha, Hanwen, Habeeb, Haroun, Rudolph, Harrison, Suk, Helen, Aspegren, Henry, Goldman, Hunter, Zhan, Hongyuan, Damlaj, Ibrahim, Molybog, Igor, Tufanov, Igor, Leontiadis, Ilias, Veliche, Irina-Elena, Gat, Itai, Weissman, Jake, Geboski, James, Kohli, James, Lam, Janice, Asher, Japhet, Gaya, Jean-Baptiste, Marcus, Jeff, Tang, Jeff, Chan, Jennifer, Zhen, Jenny, Reizenstein, Jeremy, Teboul, Jeremy, Zhong, Jessica, Jin, Jian, Yang, Jingyi, Cummings, Joe, Carvill, Jon, Shepard, Jon, McPhie, Jonathan, Torres, Jonathan, Ginsburg, Josh, Wang, Junjie, Wu, Kai, U, Kam Hou, Saxena, Karan, Khandelwal, Kartikay, Zand, Katayoun, Matosich, Kathy, Veeraraghavan, Kaushik, Michelena, Kelly, Li, Keqian, Jagadeesh, Kiran, Huang, Kun, Chawla, Kunal, Huang, Kyle, Chen, Lailin, Garg, Lakshya, A, Lavender, Silva, Leandro, Bell, Lee, Zhang, Lei, Guo, Liangpeng, Yu, Licheng, Moshkovich, Liron, Wehrstedt, Luca, Khabsa, Madian, Avalani, Manav, Bhatt, Manish, Mankus, Martynas, Hasson, Matan, Lennie, Matthew, Reso, Matthias, Groshev, Maxim, Naumov, Maxim, Lathi, Maya, Keneally, Meghan, Liu, Miao, Seltzer, Michael L., Valko, Michal, Restrepo, Michelle, Patel, Mihir, Vyatskov, Mik, Samvelyan, Mikayel, Clark, Mike, Macey, Mike, Wang, Mike, Hermoso, Miquel Jubert, Metanat, Mo, Rastegari, Mohammad, Bansal, Munish, Santhanam, Nandhini, Parks, Natascha, White, Natasha, Bawa, Navyata, Singhal, Nayan, Egebo, Nick, Usunier, Nicolas, Mehta, Nikhil, Laptev, Nikolay Pavlovich, Dong, Ning, Cheng, Norman, Chernoguz, Oleg, Hart, Olivia, Salpekar, Omkar, Kalinli, Ozlem, Kent, Parkin, Parekh, Parth, Saab, Paul, Balaji, Pavan, Rittner, Pedro, Bontrager, Philip, Roux, Pierre, Dollar, Piotr, Zvyagina, Polina, Ratanchandani, Prashant, Yuvraj, Pritish, Liang, Qian, Alao, Rachad, Rodriguez, Rachel, Ayub, Rafi, Murthy, Raghotham, Nayani, Raghu, Mitra, Rahul, Parthasarathy, Rangaprabhu, Li, Raymond, Hogan, Rebekkah, Battey, Robin, Wang, Rocky, Howes, Russ, Rinott, Ruty, Mehta, Sachin, Siby, Sachin, Bondu, Sai Jayesh, Datta, Samyak, Chugh, Sara, Hunt, Sara, Dhillon, Sargun, Sidorov, Sasha, Pan, Satadru, Mahajan, Saurabh, Verma, Saurabh, Yamamoto, Seiji, Ramaswamy, Sharadh, Lindsay, Shaun, Feng, Sheng, Lin, Shenghao, Zha, Shengxin Cindy, Patil, Shishir, Shankar, Shiva, Zhang, Shuqiang, Wang, Sinong, Agarwal, Sneha, Sajuyigbe, Soji, Chintala, Soumith, Max, Stephanie, Chen, Stephen, Kehoe, Steve, Satterfield, Steve, Govindaprasad, Sudarshan, Gupta, Sumit, Deng, Summer, Cho, Sungmin, Virk, Sunny, Subramanian, Suraj, Choudhury, Sy, Goldman, Sydney, Remez, Tal, Glaser, Tamar, Best, Tamara, Koehler, Thilo, Robinson, Thomas, Li, Tianhe, Zhang, Tianjun, Matthews, Tim, Chou, Timothy, Shaked, Tzook, Vontimitta, Varun, Ajayi, Victoria, Montanez, Victoria, Mohan, Vijai, Kumar, Vinay Satish, Mangla, Vishal, Ionescu, Vlad, Poenaru, Vlad, Mihailescu, Vlad Tiberiu, Ivanov, Vladimir, Li, Wei, Wang, Wenchen, Jiang, Wenwen, Bouaziz, Wes, Constable, Will, Tang, Xiaocheng, Wu, Xiaojian, Wang, Xiaolan, Wu, Xilun, Gao, Xinbo, Kleinman, Yaniv, Chen, Yanjun, Hu, Ye, Jia, Ye, Qi, Ye, Li, Yenda, Zhang, Yilin, Zhang, Ying, Adi, Yossi, Nam, Youngjin, Yu, Wang, Zhao, Yu, Hao, Yuchen, Qian, Yundi, Li, Yunlu, He, Yuzi, Rait, Zach, DeVito, Zachary, Rosnbrick, Zef, Wen, Zhaoduo, Yang, Zhenyu, Zhao, Zhiwei, Ma, Zhiyu

Modern artificial intelligence (AI) systems are powered by foundation models. This paper presents a new set of foundation models, called Llama 3. It is a herd of language models that natively support multilinguality, coding, reasoning, and tool usage

Externí odkaz: http://arxiv.org/abs/2407.21783

Disaggregated Multi-Tower: Topology-aware Modeling Technique for Efficient Large-Scale Recommendation

Autor: Luo, Liang, Zhang, Buyun, Tsang, Michael, Ma, Yinbin, Chu, Ching-Hsiang, Chen, Yuxin, Li, Shen, Hao, Yuchen, Zhao, Yanli, Lakshminarayanan, Guna, Wen, Ellie Dingqiao, Park, Jongsoo, Mudigere, Dheevatsa, Naumov, Maxim

We study a mismatch between the deep learning recommendation models' flat architecture, common distributed training paradigm and hierarchical data center topology. To address the associated inefficiencies, we propose Disaggregated Multi-Tower (DMT),

Externí odkaz: http://arxiv.org/abs/2403.00877

A Malware Classification Survey on Adversarial Attacks and Defences

Autor: Ponnuru, Mahesh Datta Sai, Amasala, Likhitha, Bhimavarapu, Tanu Sree, Garikipati, Guna Chaitanya

As the number and complexity of malware attacks continue to increase, there is an urgent need for effective malware detection systems. While deep learning models are effective at detecting malware, they are vulnerable to adversarial attacks. Attacks

Externí odkaz: http://arxiv.org/abs/2312.09636

Assessing thermal and economic performance of solar dryers in sustainable strategies for bottle gourd and tomato preservation

Autor: Subbarama Kousik Suraparaju, Elavarasan Elangovan, Guna Muthuvairavan, Mahendran Samykano, P. V. Elumalai, Sendhil Kumar Natarajan, Reji Kumar Rajamony, Dhinesh Balasubramanian, Yasser Fouad, Manzoore Elahi M. Soudagar, Zhang Miao, Krishna Moorthy Sivalingam

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract The traditional approach of open-sun drying is facing contemporary challenges arising from the widespread adoption of energy-intensive methods and the quality of drying. In response, solar dryers have emerged as a sustainable alternative, ut

Externí odkaz: https://doaj.org/article/474d8944d9224981b72417e237705049