Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gulnaz, Khafizova"'
Autor:
Gontcharov Alexander, Bernatchez Michel, Sam Tadayon, Michel Cantin, Gulnaz Khafizova, Qing Yu, Dahui Zhou, Gary Paul Stack, Chia-Cheng Shaw, Lankau Mark, John R. Potoski, Jonathan Laird Gross
Publikováno v:
Organic Process Research & Development. 14:1438-1447
A new practical synthesis of a 5-HT2C receptor agonist has been developed and implemented on multikilogram scale. The key step, the selective epoxide opening in the glycidyl tosylate with the aryl ...
Autor:
Aranapakam Mudumbai Venkatesan, Christoph Martin Dehnhardt, Osvaldo Dos Santos, Larry Feldberg, Gulnaz Khafizova, Judy Lucas, Robert Mallon, Natasja Brooijmans, Robert T. Abraham, Zecheng Chen, Inder Chaudhary, James Joseph Gibbons, Ker Yu, Efren Guillermo Delos Santos, Tarek S. Mansour, Irwin Hollander, Semiramis Ayral-Kaloustian
Publikováno v:
Journal of Medicinal Chemistry. 53:2636-2645
The PI3K/Akt signaling pathway is a key pathway in cell proliferation, growth, survival, protein synthesis, and glucose metabolism. It has been recognized recently that inhibiting this pathway might provide a viable therapy for cancer. A series of bi
Autor:
Ker Yu, Tarek S. Mansour, Judy Lucas, Aranapakam Mudumbai Venkatesan, Efren Guillermo Delos Santos, Matthew Gregory Bursavich, Osvaldo Dos Santos, Adam M. Gilbert, Semiramis Ayral-Kaloustian, Zecheng Chen, John W. Ellingboe, Larry Feldberg, Christoph Martin Dehnhardt, Jay Gibbons, Gulnaz Khafizova, Robert T. Abraham, Natasja Brooijmans, Irwin Hollander, Robert Mallon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:653-656
This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and
Publikováno v:
Organic Process Research & Development. 12:424-428
Practical synthesis of aminoester 1 starting from 1,1,1-trifluoro-3-iodopropane is presented. Use of Ti(Oi-Pr)4 as a Lewis acid for condensation of intermediate aldehyde 8 with (S)-(+)-p-toluenesulfinamide was found to be critical. Conditions for a r
Autor:
Richard Hernandez, Girija Krishnamurthy, Frank Loganzo, Arie Zask, Ayako Yamashita, Gary Harold Birnberg, Lee M. Greenberger, Zhilian Tang, Sylvia Musto, Tami Annable, Derek C. Cole, Xiaoran Yang, Robert Williamson, Semiramis Ayral-Kaloustian, Gulnaz Khafizova, Carolyn Discafani, Emily B. Norton, Katherine Cheung, Chuan Niu, Ronald Suayan, Joshua Kaplan, Carl Beyer
Publikováno v:
Journal of Medicinal Chemistry. 47:4774-4786
Hemiasterlin (1), a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286 (2), an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its po
Autor:
Arie, Zask, Gary, Birnberg, Katherine, Cheung, Joshua, Kaplan, Chuan, Niu, Emily, Norton, Ronald, Suayan, Ayako, Yamashita, Derek, Cole, Zhilian, Tang, Girija, Krishnamurthy, Robert, Williamson, Gulnaz, Khafizova, Sylvia, Musto, Richard, Hernandez, Tami, Annable, Xiaoran, Yang, Carolyn, Discafani, Carl, Beyer, Lee M, Greenberger, Frank, Loganzo, Semiramis, Ayral-Kaloustian
Publikováno v:
Journal of medicinal chemistry. 47(19)
Hemiasterlin, a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286, an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its potent ant
Autor:
Gloria Jean Macewan, Chuansheng Niu, J.S. Skotnicki, Dauphine Barone, A. Zask, C. Crago, Ayral-Kaloustian Semiranis, Amy Sung, Roy A. Black, R. Cowling, Kendall M. Mohler, Terri Cummons, Gulnaz Khafizova, Jeremy I. Levin, Derek C. Cole, E. Delos Santos, E.J. Salaski, Katherine Cheung, G. Jin, Yuhua Zhang, Weixin Xu, X. Du, James M. Chen, Jun Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(16)
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors, all bearing a butynyloxy P1' group, was explored. In particular, compound 5j has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1
Autor:
Frank Loganzo, Discafani, Carolyn M., Tami Annable, Carl Beyer, Sylvia Musto, Malathi Hari, Xingzhi Tan, Carolyn Hardy, Richard Hernandez, Michelle Baxter, Thiruvikraman Singanallore, Gulnaz Khafizova, Poruchynsky, Marianne S., Tito Fojo, James Nieman, Semiramis Ayral-Kaloustian, Arie Zask, Andersen, Raymond J., Greenberger, Lee M.
Publikováno v:
Scopus-Elsevier
University of Michigan Symplectic Elements
James A. Nieman
The Lens
University of Michigan Symplectic Elements
James A. Nieman
The Lens
Hemiasterlin is a natural product derived from marine sponges that, like other structurally diverse peptide-like molecules, binds to the Vinca-peptide site in tubulin, disrupts normal microtubule dynamics, and, at stoichiometric amounts, depolymerize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a76c907de35fd1cc5bee942cf97ea656
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037447174&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0037447174&partnerID=MN8TOARS