Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gulfem Guler"'
Autor:
Gulfem Guler, Yuhong Ning, David Haan, Michael Kesling, Ceyda Coruh, Giuliana Mognol, Tierney Phillips, Kyle Hazen, Wayne Volkmuth, Samuel Levy
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Anna Bergamaschi, David Haan, Micah Collins, Gulfem Guler, Melissa Peters, Lauren Gigliotti, Shimul Chowdhury, Wayne Volkmuth, Samuel Levy
Publikováno v:
Journal of Clinical Oncology. 41:672-672
672 Background: Pancreatic cancer is one of the deadliest cancers, with approximately 15-20% of patients who present at diagnosis with a resectable disease. The major barrier to better outcomes is the lack of early-detection molecular tools to enable
Autor:
Tierney Phillips, Erin McCarthy, Chin-Jen Ku, Yuhong Ning, Francois Collin, Christopher K. Ellison, Wendy Wang, Samuel Levy, Paul Lloyd, Kim Chau, Gulfem Guler, Anna Bergamaschi, Stephen R. Quake, Alan Ashworth, Michael Antoine, Aaron Scott
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Pancreatic cancer is often detected late, when curative therapies are no longer possible. Here, we present non-invasive detection of pancreatic ductal adenocarcinoma (PDAC) by 5-hydroxymethylcytosine (5hmC) changes in circulating cell free DNA from a
Autor:
Anna Bergamaschi, David Haan, Micah Collins, Gulfem Guler, Melissa Peters, Lauren Gigliotti, Shimul Chowdhury, Wayne Volkmuth, Samuel Levy
Publikováno v:
Cancer Research. 82:A027-A027
Background: Pancreatic cancer outcomes are poor, mostly due to the detection of cancer at late stages. Early-detection enables prompt initiation of treatment and has been reported to significantly improve outcomes. We have developed a novel sequencin
Here we present a method for 5-hydroxymethyl cytosine enrichment from cell free DNA or fragmented genomic DNA. This method is based on Song et al (1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::844aff55f57f635da0f3c43818a2b7c6
https://doi.org/10.21203/rs.3.pex-1117/v1
https://doi.org/10.21203/rs.3.pex-1117/v1
Publikováno v:
Journal of Clinical Oncology. 40:539-539
539 Background: Pancreatic cancer (PaCa) is the third leading cause of cancer death in the United States despite a low incidence rate. It is often diagnosed when cancer has already metastasized to distant organs. Late diagnosis deprives patients of p
Autor:
Aaron Scott, Tierney Phillips, Michael Antoine, Alan Ashworth, Anna Bergamaschi, Francois Collin, Wendy Wang, Samuel Levy, Steve Quake, Chin-Jen Ku, Gulfem Guler, Yuhong Ning, Erin McCarthy, Christopher K. Ellison, Paul Lloyd
Our study employed the detection of 5-hydroxymethyl cytosine (5hmC) profiles on cell free DNA (cfDNA) from the plasma of cancer patients using a novel enrichment technology coupled with sequencing and machine learning based classification method. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336ab7abd7aee8da816dc5e06f80662b
Autor:
Kyle Hazen, Kelly Bethel, Christopher K. Ellison, Michael Kesling, Judy Sheard, Aaron Scott, David Haan, Albert Nguyen, Samuel Levy, Gulfem Guler, Melissa Peters, William Gibb, Wayne Volkmuth, Anna Bergamaschi, Yuhong Ning, Carolina Fraire, Roger Malta, Samuel Woldeyohanne, Michael Antoine
Publikováno v:
Journal of Clinical Oncology. 39:e16265-e16265
e16265 Background: Pancreatic cancer (PaCa) is the third leading cause of cancer death in the United States despite its low incidence rate, owing to a 5-year survival rate of 10%. It is often asymptomatic in early stage, resulting in the majority of
Autor:
Yuhong Ning, Erin McCarthy, Michael Kesling, Roger Malta, Kelly Bethel, William Gibb, Albert Nguyen, Maryam Nabiyouni, Tierney Phillips, Anna Bergamaschi, Wayne Volkmuth, Gulfem Guler, Judy Sheard, Christopher K. Ellison, David Haan, Adriana Pitea, Samuel Levy, Kyle Hazen, Aaron Scott, Melissa Peters
Publikováno v:
Journal of Clinical Oncology. 39:3044-3044
3044 Background: Epigenomics assays have recently become popular tools for identification of molecular biomarkers, both in tissue and in plasma. In particular 5-hydroxymethyl-cytosine (5hmC) method, has been shown to enable the epigenomic regulation
Autor:
Francois Collin, Christopher K. Ellison, Jeremy Ku, Samuel Levy, Wendy Wang, Anna Bergamaschi, Tierney Phillips, Paul Lloyd, David Haan, Erin McCarthy, Yuhong Ning, Gulfem Guler, Stephen R. Quake, Alan Ashworth, Michael Antoine, Aaron Scott
Publikováno v:
Cancer Research. 80:783-783
Background: Our feasibility study employed a novel genomic detection methodology that enriches 5-hydroxymethylcytosine (5hmC) loci in cell free DNA (cfDNA) from the plasma of cancer patients using click chemistry coupled with sequencing and machine l