Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Gulebahar Sheikh"'
Autor:
Sunita M. de Sousa, Prashanti Madhavapeddi, Aishwarya Sundaram, Md. Gulebahar Sheikh, Kakoli Mukherjee, Reetobrata Basu, Vaishali Humnabadkar, Rajendra Rane, Halesha D. Basavarajappa, Prateek Verma
Publikováno v:
SLAS Discovery. 20:265-274
Mycobacterium tuberculosis (Mtb) DNA gyrase ATPase was the target of a tuberculosis drug discovery program. The low specific activity of the Mtb ATPase prompted the use of Mycobacterium smegmatis (Msm) enzyme as a surrogate for lead generation, since
Autor:
David Waterson, Vijender Panduga, Gajanan Shanbhag, Jim Werngren, Sheshagiri Gaonkar, Manjunatha R, Gulebahar Sheikh, Prashanti Madhavapeddi, Reetobrata Basu, Kakoli Mukherjee, Radha Shandil, Jitendar Reddy, Vrinda Nandi, Mahesh Kumar, Suresh Solapure, Venkita Subbulakshmi, Anirban Ghosh, Disha Awasthy, Praveena Manjrekar, Jon Read, Meenakshi Balganesh, Abhijeet Deshpande, Vaishali Humnabadkar, Anand Kumar V. Raichurkar, Sven Hoffner, Helen H.J. McMiken, Shahul Hameed P, Vasan K. Sambandamurthy, Sreevalli Sharma, Jayashree Puttur, Murugan Chinnapattu
Publikováno v:
Antimicrobial agents and chemotherapy. 58(1)
Moxifloxacin has shown excellent activity against drug-sensitive as well as drug-resistant tuberculosis (TB), thus confirming DNA gyrase as a clinically validated target for discovering novel anti-TB agents. We have identified novel inhibitors in the
Autor:
Umender Sharma, Venkita Subbulakshmi, Jyothi Bhat, Gulebahar Sheikh, Sudha Ravishankar, Anisha Ambady, Vasan K. Sambandamurthy, Kakoli Mukherjee, Disha Awasthy
Publikováno v:
Microbiology (Reading, England). 156(Pt 9)
Pantothenate kinase, an essential enzyme in bacteria and eukaryotes, is involved in catalysing the first step of conversion of pantothenate to coenzyme A (CoA). Three isoforms (type I, II and III) of this enzyme have been reported from various organi