APOE4/4 is linked to damaging lipid droplets in Alzheimer's microglia.

Autor: Haney MS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Equal contribution., Pálovics R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Equal contribution., Munson CN; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Long C; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Johansson P; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Yip O; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Dong W; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., Rawat E; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., West E; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA., Schlachetzki JC; Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, CA 92093, USA., Tsai A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Guldner IH; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Lamichhane BS; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Smith A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Schaum N; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Calcuttawala K; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Shin A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Wang YH; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Wang C; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US., Koutsodendris N; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US., Serrano GE; Laboratory of Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Beach TG; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Reiman EM; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, AZ, USA., Glass CK; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US., Abu-Remaileh M; The Institute for Chemistry, Engineering & Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA., Enejder A; Department of Materials Science & Engineering Department, Stanford University, Stanford, CA 94305, USA., Huang Y; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, US.; Biomedical Sciences Graduate Program, University of California, San Francisco, US.; Development and Stem Cell Biology Graduate Program, University of California, San Francisco, US.; Department of Neurology, University of California, San Francisco, CA, USA., Wyss-Coray T; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 25. Date of Electronic Publication: 2023 Jul 25.