Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gulay Filiz"'
Publikováno v:
Bio-Protocol, Vol 8, Iss 17 (2018)
Glioma stem cells (GSC) grown as neurospheres exhibit similar characteristics to neural stem cells (NSC) grown as neurospheres, including the ability to self-renew and differentiate. GSCs are thought to play a role in cancer initiation and progressio
Externí odkaz:
https://doaj.org/article/a3bb871dbb8a44fd85db04adbe4846fc
Autor:
Daniel V Brown, Gulay Filiz, Paul M Daniel, Frédéric Hollande, Sebastian Dworkin, Stephanie Amiridis, Nicole Kountouri, Wayne Ng, Andrew P Morokoff, Theo Mantamadiotis
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://doaj.org/article/5a7ac15d4e7045b793592d822cc16281
Autor:
Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17669 (2011)
We have previously demonstrated that brief treatment of APP transgenic mice with metal ionophores (PBT2, Prana Biotechnology) rapidly and markedly improves learning and memory. To understand the potential mechanisms of action underlying this phenomen
Externí odkaz:
https://doaj.org/article/4e763946483f42a89c147264e6af3f94
Autor:
Paul M. Daniel, Frédéric Hollande, Andrew P. Morokoff, Gulay Filiz, Sebastian Dworkin, Theo Mantamadiotis, Daniel Brown, Wayne Ng, Nicole Kountouri, Stephanie Amiridis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93541fc9763c8c99c234f613764a359
Autor:
Andrew H. Kaye, Stanley S. Stylli, Gulay Filiz, Paul M. Daniel, Martin James Tymms, Theo Mantamadiotis, Robert G. Ramsay
Publikováno v:
Experimental and molecular pathology. 105(1)
Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due to intratumor heterogeneity. Heterogeneity arises due to the genetic and epigenetic variation of tumor cells in respons
Autor:
Elizabeth Vincan, Karen G. Montgomery, Paul Waring, Colin W. Pouton, Yi Zhang, Dustin J. Flanagan, Daniel V Brown, Gulay Filiz, John M. Haynes, Terrance Grant Johns, Theo Mantamadiotis, Paul M. Daniel, Wayne A. Phillips, Michael Christie
BACKGROUND: Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling is common in cancers, but the precise role of the pathway in glioma biology remains to be determined. Some understanding of PI3K signaling mechanisms in brain cancer comes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b28a2a34b083720063fa59e8cefe933
https://europepmc.org/articles/PMC6140786/
https://europepmc.org/articles/PMC6140786/
Autor:
Paul M. Daniel, Stanley S. Stylli, Martin J. Tymms, Theo Mantamadiotis, Robert G. Ramsay, Andrew H. Kaye, Gulay Filiz
Limitations in discovering useful tumor biomarkers and drug targets is not only due to patient-to-patient differences but also due to intratumoral heterogeneity. Heterogeneity arises due to the genetic and epigenetic variation of tumor cells in respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7e6ad528bfc9fa6f78836b58125277
Autor:
Yi Zhang, Paul Waring, Terrance Grant Johns, Gulay Filiz, Daniel V Brown, Paul M. Daniel, John M. Haynes, Elizabeth Vincan, Karen G. Montgomery, Theo Mantamadiotis, Michael Christie, Colin W. Pouton, Wayne A. Phillips, Dustin J. Flanagan
Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma biology remains to be determined. Some limited understanding of PI3K signaling in brain cancer come from studies on neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d2511405c94e1768e17a4a0d55b35f
Autor:
Dustin J. Flanagan, Yi Zhang, Paul Daniel, Michael Christie, Paul Waring, Gulay Filiz, Colin W. Pouton, Elizabeth Vincan, Theo Mantamadiotis, Wayne A. Phillips
Publikováno v:
ESMO Open. 3:A305-A306
Introduction Hyperactivation of the PI3K signalling is common in cancers but the precise role of the pathway in glioma biology remains to be determined. Some understanding of PI3K signalling mechanisms in brain cancer comes from studies on neural ste
Publikováno v:
Cell Death & Disease
In some cell types, activation of the second messenger cAMP leads to increased expression of proapoptotic Bim and subsequent cell death. We demonstrate that suppression of the cAMP pathway is a common event across many cancers and that pharmacologica