Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Guk Yeol Park"'
Autor:
Sungjun Park, Seungwon Lee, Choong-Gu Lee, Guk Yeol Park, Hyebeen Hong, Jeon-Soo Lee, Young Min Kim, Sung Bae Lee, Daehee Hwang, Youn Soo Choi, John D. Fryer, Sin-Hyeog Im, Seung-Woo Lee, Yoontae Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH different
Externí odkaz:
https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc
Autor:
Jongmin Park, Guk-Yeol Park, Jongeun Lee, Joonyoung Park, Soeun Kim, Eunjeong Kim, Seung-Yeol Park, Jong Hyuk Yoon, Yoontae Lee
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic translocation. Although CIC is known to be inactivated by phosphorylation
Externí odkaz:
https://doaj.org/article/cbfd1fc91c464e58a40d7e99f43d91ff
Publikováno v:
eLife, Vol 10 (2021)
Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that Capicua (CIC
Externí odkaz:
https://doaj.org/article/750cfe750b534b1f82aec2f59998e216
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, the dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that capicua
Autor:
Hyebeen Hong, Jongeun Lee, Guk-Yeol Park, Soeun Kim, Jiho Park, Jong Seok Park, Youngkwon Song, Sujin Lee, Tae Jin Kim, You Jeong Lee, Tae-Young Roh, Seung-Ki Kwok, Sung Won Kim, Qiumin Tan, Yoontae Lee
Publikováno v:
Cell reports. 38(7)
B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 cell development at the adult stage. We report that capicua (CIC)
Autor:
Kyung-Sik Lee, Hye-Seong Park, Guk-Yeol Park, Gi-Chan Lee, Eun-Ji Choi, Jae-in Yu, Seung-Joo Yang, Mihwa Kim, Yoonjoo Choi, Je-Jung Lee, Joon Haeng Rhee, Bum Chan Park, Jae Eun Park
Publikováno v:
Cancer Research. 82:6189-6189
[Purpose] Immunosuppressive tumor microenvironment (TME) is the major hurdle to cancer immunotherapy. Advanced hepatocellular carcinoma (aHCC) is one of the representative cold tumors with immunosuppressive TME and presents obvious correlation betwee
Publikováno v:
Immune Network
Capicua (CIC) is a transcriptional repressor that regulates several developmental processes. CIC deficiency results in lymphoproliferative autoimmunity accompanied by expansion of CD44hiCD62Llo effector/memory and follicular Th cell populations. Dele
Autor:
Guk Yeol Park, Sin-Hyeog Im, Youn Soo Choi, Yoontae Lee, Choong-Gu Lee, Daehee Hwang, Sung Bae Lee, Hyebeen Hong, Seung-Woo Lee, Young-Min Kim, John D. Fryer, Sungjun Park, Jeon Soo Lee, Seung Won Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
NATURE COMMUNICATIONS(8)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
NATURE COMMUNICATIONS(8)
High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens, subsequently leading to autoim