Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Guizhi Zhu"'
Autor:
Shurong Zhou, Ting Su, Furong Cheng, Janet Cole, Xiang Liu, Bei Zhang, Shaheer Alam, Jinze Liu, Guizhi Zhu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102126- (2024)
Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, w
Externí odkaz:
https://doaj.org/article/5f853ee47ae04af296e6509b22dc1941
Publikováno v:
Bioactive Materials, Vol 26, Iss , Pp 169-180 (2023)
Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here, we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkp
Externí odkaz:
https://doaj.org/article/0d7e88e8065e41d089a08e565c4fc2be
Publikováno v:
Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease with pathogenic inflammation caused partly by excessive cell‐free DNA (cfDNA). Specifically, cfDNA is internalized into immune cells, such as macrophages in lymphoid tissues and jo
Externí odkaz:
https://doaj.org/article/6508f4c48dd044dea2712a703f4ecbda
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/bc8db5fd94b94ba1a9d688dff8b74990
Autor:
Jing Chen, Renhua Li, Sarah Knapp, Guizhi Zhu, Robert L. Whitener, Edward H. Leiter, Clayton E. Mathews
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linka
Externí odkaz:
https://doaj.org/article/82a6c4483edb4bac8e73ce8786c571f7
Autor:
Ting Su, Furong Cheng, Jialong Qi, Yu Zhang, Shurong Zhou, Lei Mei, Shiwei Fu, Fuwu Zhang, Shuibin Lin, Guizhi Zhu
Publikováno v:
Advanced Science, Vol 9, Iss 23, Pp n/a-n/a (2022)
Abstract Immune checkpoint blockade (ICB) has significantly advanced cancer immunotherapy, yet its patient response rates are generally low. Vaccines, including immunostimulant‐adjuvanted peptide antigens, can improve ICB. The emerging neoantigens
Externí odkaz:
https://doaj.org/article/e6f1d4fe8f694f6ca65cfe134a785446
Publikováno v:
Medicine in Drug Discovery, Vol 6, Iss , Pp 100023- (2020)
Cancer immunotherapy has shown great potential as witnessed by an increasing number of immuno-oncology drug approvals in the past few years. Meanwhile, the field of nucleic acid therapeutics has made significant advancement. Nucleic acid therapeutics
Externí odkaz:
https://doaj.org/article/4361f428d2b3430baa1dbeee95e9fff3
Autor:
Guizhi Zhu, Geoffrey M. Lynn, Orit Jacobson, Kai Chen, Yi Liu, Huimin Zhang, Ying Ma, Fuwu Zhang, Rui Tian, Qianqian Ni, Siyuan Cheng, Zhantong Wang, Nan Lu, Bryant C. Yung, Zhe Wang, Lixin Lang, Xiao Fu, Albert Jin, Ido D. Weiss, Harshad Vishwasrao, Gang Niu, Hari Shroff, Dennis M. Klinman, Robert A. Seder, Xiaoyuan Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable a
Externí odkaz:
https://doaj.org/article/6c1cbd8acb2f42149db4a8201852deb6
Autor:
Guizhi Zhu, Lei Mei, Harshad D. Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C. Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short h
Externí odkaz:
https://doaj.org/article/c51e8ed297cd4c9da385abee4fc19f46
Autor:
Thu Le Trinh, Guizhi Zhu, Xilin Xiao, William Puszyk, Kwame Sefah, Qunfeng Wu, Weihong Tan, Chen Liu
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0136673 (2015)
AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major s
Externí odkaz:
https://doaj.org/article/50235ec794534823a9923e751d161af1