Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Guizhen Zhao"'
Autor:
Guizhen Zhao, Yang Zhao, Wenying Liang, Haocheng Lu, Hongyu Liu, Yongjie Deng, Tianqing Zhu, Yanhong Guo, Lin Chang, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Atherosclerotic cardiovascular diseases remain the leading cause of mortality in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of atherosclerosis, which is exacerbated in diabetes. Krüpp
Externí odkaz:
https://doaj.org/article/5ceec1f643e142d68958d73f93f18010
Autor:
Yang Zhao, Yuhao Liu, Guizhen Zhao, Haocheng Lu, Yaozhong Liu, Chao Xue, Ziyi Chang, Hongyu Liu, Yongjie Deng, Wenying Liang, Huilun Wang, Oren Rom, Minerva T. Garcia-Barrio, Tianqing Zhu, Yanhong Guo, Lin Chang, Jiandie Lin, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113171- (2023)
Summary: Atherosclerosis, a leading health concern, stems from the dynamic involvement of immune cells in vascular plaques. Despite its significance, the interplay between chromatin remodeling and transcriptional regulation in plaque macrophages is u
Externí odkaz:
https://doaj.org/article/7f6e0a8a2aac415a91ad2bfbfacec5a1
Generating endogenous Myh11-driven Cre mice for sex-independent gene deletion in smooth muscle cells
Autor:
Yang Zhao, Guizhen Zhao, Ziyi Chang, Tianqing Zhu, Ying Zhao, Haocheng Lu, Chao Xue, Thomas L. Saunders, Yanhong Guo, Lin Chang, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Specific and efficient smooth muscle cell–targeted (SMC-targeted) gene deletion is typically achieved by pairing SMMHC-CreERT2-Tg mice with mice carrying the loxP-flanked gene. However, the transgene, CreERT2, is not controlled by the endogenous My
Externí odkaz:
https://doaj.org/article/74eb55d98c434fd7bb219e2249e98246
Autor:
Zhenguo Wang, Xiangjie Zhao, Guizhen Zhao, Yanhong Guo, Haocheng Lu, Wenjuan Mu, Juan Zhong, Minerva Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen, Lin Chang
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis.
Externí odkaz:
https://doaj.org/article/c08a65c52abf4b7d801fbe9fe8bb0587
Publikováno v:
Cells, Vol 13, Iss 2, p 168 (2024)
Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose
Externí odkaz:
https://doaj.org/article/5c4ecc0a599a45c7b44c6e9388c90728
Autor:
Guizhen Zhao, Yang Zhao, Haocheng Lu, Ziyi Chang, Hongyu Liu, Huilun Wang, Wenying Liang, Yuhao Liu, Tianqing Zhu, Oren Rom, Yanhong Guo, Lin Chang, Bo Yang, Minerva T. Garcia-Barrio, Jiandie D. Lin, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. BAF60c, a unique subunit of the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex, is critical for cardiac and skeletal myogenesis, yet little is known about i
Externí odkaz:
https://doaj.org/article/f481e3bf2ae0477d901fa50cbb6c472b
Autor:
Yuhao Liu, Ying Zhao, Yousef Shukha, Haocheng Lu, Lu Wang, Zhipeng Liu, Cai Liu, Yang Zhao, Huilun Wang, Guizhen Zhao, Wenying Liang, Yanbo Fan, Lin Chang, Arif Yurdagul, Jr., Christopher B. Pattillo, A. Wayne Orr, Michael Aviram, Bo Wen, Minerva T. Garcia-Barrio, Jifeng Zhang, Wanqing Liu, Duxin Sun, Tony Hayek, Y. Eugene Chen, Oren Rom
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109420- (2021)
Summary: Dysregulated glycine metabolism is emerging as a common denominator in cardiometabolic diseases, but its contribution to atherosclerosis remains unclear. In this study, we demonstrate impaired glycine-oxalate metabolism through alanine-glyox
Externí odkaz:
https://doaj.org/article/cd26e64f714e496680a0eaa2799a0feb
Autor:
Guizhen Zhao, Haocheng Lu, Yuhao Liu, Yang Zhao, Tianqing Zhu, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Atherosclerosis is the leading cause of cardiovascular diseases, which is also the primary cause of mortality among diabetic patients. Endothelial cell (EC) dysfunction is a critical early step in the development of atherosclerosis and aggravated in
Externí odkaz:
https://doaj.org/article/ac4c1cafcaea49af835bcdd519cc69b9
Autor:
Guizhen Zhao, Ziyi Chang, Yang Zhao, Yanhong Guo, Haocheng Lu, Wenying Liang, Oren Rom, Huilun Wang, Jinjian Sun, Tianqing Zhu, Yanbo Fan, Lin Chang, Bo Yang, Minerva T. Garcia-Barrio, Y. Eugene Chen, Jifeng Zhang
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Krüppel-like factor 11 (KLF11) plays an essential role in maintaining v
Externí odkaz:
https://doaj.org/article/9de0556f12e74a12bf703fef9cfea9ce
Publikováno v:
ACS Applied Bio Materials. 6:2003-2013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468622cc1aa3cf5fcd063604c3f5081b
https://doi.org/10.1021/acsabm.3c00267
https://doi.org/10.1021/acsabm.3c00267