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Akademický článek

Functional analysis of a novel nonsense variant c.91A>T of the TRAPPC2 gene in a Chinese family with X-linked recessive autosomal spondyloepiphyseal dysplasia tarda

Autor: Guiyu Lou, Yuanyin Zhao, Huiru Zhao, Yuwei Zhang, Bingtao Hao, Litao Qin, Hongyan Liu, Shixiu Liao

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Spondyloepiphyseal dysplasia tarda (SEDT) is a condition involving late-onset, X-linked recessive skeletal dysplasia caused by mutations in the TRAPPC2 gene. In this paper, we identified a novel nonsense variant in a SEDT pedigree and analyzed the fu

Externí odkaz: https://doaj.org/article/b17e5cbbf7b64521b2b0f00863329645

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Akademický článek

Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5.

Autor: Xiaosong Chen, Haixia Xu, Lili Ding, Guiyu Lou, Yan Liu, Yalan Yao, Liangwan Chen, Wendong Huang, Xianghui Fu

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131294 (2015)

GPBAR1/TGR5 is a G protein-coupled receptor of bile acids. TGR5 is known to regulate the BA homeostasis and energy metabolism. Recent studies highlight an important role of TGR5 in alleviating obesity and improving glucose regulation, however, the me

Externí odkaz: https://doaj.org/article/43039037d64f45fab2886d7842ae9ebc

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Akademický článek

HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells.

Autor: Hongming Liu, Guiyu Lou, Chongyi Li, Xiaodong Wang, Arthur I Cederbaum, Lixia Gan, Bin Xie

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107913 (2014)

CYP2E1, one of the cytochrome P450 mixed-function oxidases located predominantly in liver, plays a key role in metabolism of xenobiotics including ethanol and procarcinogens. Recently, down-expression of CYP2E1 was found in hepatocellular carcinoma (

Externí odkaz: https://doaj.org/article/59c5ca7a932441bd9e268d7eb428fd68

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Akademický článek

GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells.

Autor: Guiyu Lou, Xiaoxiao Ma, Xianghui Fu, Zhipeng Meng, Wenyu Zhang, Yan-Dong Wang, Carl Van Ness, Donna Yu, Rongzhen Xu, Wendong Huang

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93567 (2014)

GPBAR1/TGR5 is a novel plasma membrane-bound G protein-coupled bile acid (BA) receptor. BAs are known to induce the expression of inflammatory cytokines in the liver with unknown mechanism. Here we show that without other external stimuli, TGR5 activ

Externí odkaz: https://doaj.org/article/6a8dd9f2586242a086792c03580c52d1

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Akademický článek

MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells.

Autor: Yuanyin Zhao, Yuping Li, Guiyu Lou, Li Zhao, Zhizhen Xu, Yan Zhang, Fengtian He

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39102 (2012)

ERRα is an orphan nuclear receptor emerging as a novel biomarker of breast cancer. Over-expression of ERRα in breast tumor is considered as a prognostic factor of poor clinical outcome. The mechanisms underlying the dysexpression of this nuclear re

Externí odkaz: https://doaj.org/article/60d852674e87401facce9bfed3ef8954

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