Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Guiying Cui"'
Autor:
Analia J. Vazquez Cegla, Kymry T. Jones, Guiying Cui, Kirsten A. Cottrill, Michael Koval, Nael A. McCarty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cystic fibrosis related diabetes (CFRD), the main co-morbidity in cystic fibrosis (CF), is associated with higher rates of lung function decline. We hypothesize that airway epithelial barrier function is impaired in CF and is further exacerb
Externí odkaz:
https://doaj.org/article/c4acfa42600a4ea5abd25fefc98c0444
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37977- (2024)
The study of many diseases is limited by the in vitro systems available. Cystic Fibrosis-Related Diabetes (CFRD), the main co-morbidity of Cystic Fibrosis (CF), is a perfect example. Cells in vivo experience glucose fluctuations after meals. In contr
Externí odkaz:
https://doaj.org/article/b8881270870a491485127d33fc990e13
Autor:
Arturo Raya-Sandino, Kristen M. Lozada-Soto, Nandhini Rajagopal, Vicky Garcia-Hernandez, Anny-Claude Luissint, Jennifer C. Brazil, Guiying Cui, Michael Koval, Charles A. Parkos, Shikha Nangia, Asma Nusrat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is attributed to differential claudin expression. He
Externí odkaz:
https://doaj.org/article/e6dc802f5ea44a33acc5626c32b09f7b
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: ATP-binding cassette (ABC) transporters use the hydrolysis of ATP to power the active transport of molecules, but paradoxically the cystic fibrosis transmembrane regulator (CFTR, ABCC7) forms an ion channel. We previously showed that AT
Externí odkaz:
https://doaj.org/article/b3cd1f4720734e46b9cde94ef7109c7e
Autor:
William D. Hunt, Nael A. McCarty, Eduardo Martinez Marin, Ryan S. Westafer, Phillip R. Yamin, Guiying Cui, Andrew W. Eckford, Douglas R. Denison
Publikováno v:
Biophysical Reports, Vol 3, Iss 2, Pp 100108- (2023)
In this paper we present a transistor circuit model for cystic fibrosis transmembrane conductance regulator (CFTR) that seeks to map the functional form of CFTR both in wild type and mutants. The circuit architecture is configured so that the functio
Externí odkaz:
https://doaj.org/article/c472d962839449f199e0a70eef5cd4ad
Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm
Autor:
Alexander S. Moffett, Guiying Cui, Peter J. Thomas, William D. Hunt, Nael A. McCarty, Ryan S. Westafer, Andrew W. Eckford
Publikováno v:
Biophysical Reports, Vol 2, Iss 4, Pp 100083- (2022)
The closing of the gated ion channel in the cystic fibrosis transmembrane conductance regulator can be categorized as nonpermissive to reopening, which involves the unbinding of ADP or ATP, or permissive, which does not. Identifying the type of closi
Externí odkaz:
https://doaj.org/article/9bb221c84752428385d49648e7edc380
Autor:
Guiying Cui, Kirsten A. Cottrill, Kerry M. Strickland, Sarah A. Mashburn, Michael Koval, Nael A. McCarty
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Altered cholesterol homeostasis in cystic fibrosis patients has been reported, although controversy remains. As a major membrane lipid component, cholesterol modulates the function of multiple ion channels by complicated mechanisms. However, whether
Externí odkaz:
https://doaj.org/article/2bf8cf834f1c40d3aa91a0b1d0b07942
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74574 (2013)
Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator protein (CFTR) cause cystic fibrosis (CF), the most common life-shortening genetic disease among Caucasians. Although general features of the structure of CFTR hav
Externí odkaz:
https://doaj.org/article/b6100b05f288425e93e2248622014f54
Autor:
Nael A. McCarty, Sarah A Mashburn, Guiying Cui, Michael Koval, Kerry M Strickland, Kirsten A. Cottrill
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, Vol 12 (2021)
Altered cholesterol homeostasis in cystic fibrosis patients has been reported, although controversy remains. As a major membrane lipid component, cholesterol modulates the function of multiple ion channels by complicated mechanisms. However, whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8053fe515a765c10a8d9592ddf3b18e7
http://europepmc.org/articles/PMC8215275
http://europepmc.org/articles/PMC8215275
Autor:
Guiying Cui, Ingeborg Schmidt-Krey, Nael A. McCarty, Daniel T. Infield, James C. Gumbart, Kerry M. Strickland, Gorman Stock, Hyea Hwang
Publikováno v:
The Journal of Physical Chemistry B. 123:3177-3188
Cystic fibrosis transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily that has uniquely evolved to function as a chloride channel. It binds and hydrolyzes ATP at its nucleotide binding domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b3690383e74ef76e02c3504b6c358b
https://doi.org/10.1021/acs.jpcb.8b11970
https://doi.org/10.1021/acs.jpcb.8b11970