Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Guiyang Yao"'
Autor:
Guiyang Yao, Simone Kosol, Marius T. Wenz, Elisabeth Irran, Bettina G. Keller, Oliver Trapp, Roderich D. Süssmuth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The occurrence of isomers of the bicyclic octapeptide α-amanitin, which presents a macrolactam with a tryptathionine cross-link forming a handle, has been reported under the term of atropoisomers. Here, the authors synthesize its analogs and analyse
Externí odkaz:
https://doaj.org/article/ffa6050476a7482bbc3dca488bc7c362
Amatoxins are strong inhibitors of RNA polymerase II, and cause cell death. Because of their cytotoxicity they are candidates for anti-cancer drugs, and understanding their structure-activity relationship is crucial. Amatoxins have a rigid bicyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d01a9fca1fc5819615bb0c181d6d7b4
https://doi.org/10.1101/2022.12.21.521444
https://doi.org/10.1101/2022.12.21.521444
Autor:
Bettina G. Keller, Hendrik Gruß, Guiyang Yao, Andreas Pahl, Marius T. Wenz, Simone Kosol, Caroline H. Knittel, Torsten Hechler, Alexandra Braun, Roderich D. Süssmuth, Christian Lutz
Publikováno v:
Journal of the American Chemical Society. 143:14322-14331
Synthetic methods on the macrocyclization of peptides are of high interest since they facilitate the synthesis of various types of potentially bioactive compounds, e.g. addressing targets like protein-protein-interactions. Herein, we report on an eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea3c528059bc7ff978e0918406aab84
https://doi.org/10.1021/jacs.1c06565
https://doi.org/10.1021/jacs.1c06565
Publikováno v:
The journal of physical chemistry. B. 126(39)
Membrane models assembled on electrodes are widely used tools to study potential-dependent molecular processes at or in membranes. However, the relationship between the electrode potential and the potential across the membrane is not known. Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b421b5c67b4a1ac77ed0f090f5009d
https://pubmed.ncbi.nlm.nih.gov/36137267
https://pubmed.ncbi.nlm.nih.gov/36137267
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(34)
Phallotoxins and amatoxins are a group of prominent peptide toxins produced by the death cap mushroom Amanita phalloides. Phalloidin is a bicyclic cyclopeptide with an unusual tryptathionin thioether bridge. It is a potent stabilizer of filamentous a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a47a102eee0201b2652a94230ef127
https://pubmed.ncbi.nlm.nih.gov/31034701
https://pubmed.ncbi.nlm.nih.gov/31034701
Autor:
Zhehong Cheng, Zhengyin Pan, Ke Liu, Wei Wang, Guiyang Yao, Chunlei Wu, Lijiao Ao, Wu Su, Lijing Fang, Hongchang Li
Publikováno v:
Journal of medicinal chemistry. 61(19)
To enable the large-scale synthesis of coibamide A, we developed an improved synthetic strategy for this class of cyclodepsipeptide. The versatility of the synthetic procedure was demonstrated by the preparation of a series of designed coibamide A an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb027176ae576246e1365d57617e8f7
https://pubmed.ncbi.nlm.nih.gov/30247036
https://pubmed.ncbi.nlm.nih.gov/30247036
Autor:
Chunlei Wu, Wei Wang, Wu Su, Zhengyin Pan, Ke Liu, Zhehong Cheng, Guiyang Yao, Lijing Fang, Hongchang Li
Publikováno v:
Organic letters. 19(17)
Gymnopeptides A and B are unprecedented highly N-methylated cyclic β-hairpin octadecapeptides with striking antiproliferative activities isolated from the mushroom Gymnopus fusipes. Using Fmoc-based solid-phase peptide synthesis, followed by macrola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c910bfc6cac5403f7a2173184813b4f9
https://pubmed.ncbi.nlm.nih.gov/28799768
https://pubmed.ncbi.nlm.nih.gov/28799768
Publikováno v:
Organic Letters. 17:158-161
The fully automated solid-phase synthetic strategy of hairpin pyrrole-imidazole polyamides is described. A key advance is the development of methodology for the application of triphosgene as a coupling agent in the automated synthesis of hairpin poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698854fffc903c31b5d1bceac6426459
https://doi.org/10.1021/ol503388a
https://doi.org/10.1021/ol503388a
Publikováno v:
International immunopharmacology. 47
Natural albumin ligand (fatty acids)-conjugated peptides can rapidly bind to circulating albumin and form complexes to control the release of peptides. The purpose of this study was to prolong the half-life and immune-modulating effects of thymopenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa44f26ba54e8c8897a4527c44b9c889
https://pubmed.ncbi.nlm.nih.gov/28365509
https://pubmed.ncbi.nlm.nih.gov/28365509
Publikováno v:
Journal of the American Chemical Society. 137(42)
Coibamide A is a highly potent antiproliferative cyclodepsipeptide originally isolated from a Panamanian marine cyanobacterium. Herein we report an efficient solid-phase strategy for assembly of highly N-methylated cyclodepsipeptides, which is invalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f539dc01d07002db848b6fd7ad2fc0
https://pubmed.ncbi.nlm.nih.gov/26469305
https://pubmed.ncbi.nlm.nih.gov/26469305