Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Guixue Yu"'
Autor:
Jacques Y. Roberge, Guixue Yu, Amarendra Mikkilineni, Ximao Wu, Yeheng Zhu, R. Michael Lawrence, William R. Ewing
Publikováno v:
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Externí odkaz:
https://doaj.org/article/354d14f1bfc542a0ac1e7157fd9b7867
Autor:
Kenneth E. Carlson, Olafur S. Gudmundsson, Bruce A. Ellsworth, Philip M. Sher, Susan Harvey, Eva Zuvich, Michael Thomas, William J. Keim, Gang Wu, Helen E. Godonis, Paul Stetsko, Brian J. Murphy, Richard B. Sulsky, Guixue Yu, William R. Ewing, Mary Jane Cullen, Mary Ann Pelleymounter, Doree F. Sitkoff, Susan Johnghar, Zhengxiang Gu, Ximao Wu, James Devenny, Rose Ann F Baska, Asoka Ranasinghe, Ning Lee, Kamelia Behnia, Anthony V. Azzara, Kenneth W. Rohrbach, Gerry Everlof, Liya Kang, Natesan Murugesan, Yeheng Zhu, Yifan Yang
Publikováno v:
Journal of Medicinal Chemistry. 56:9586-9600
Several strategies have been employed to reduce the long in vivo half-life of our lead CB1 antagonist, triazolopyridazinone 3, to differentiate the pharmacokinetic profile versus the lead clinical compounds. An in vitro and in vivo clearance data set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417c836ddf3010c89cd9792afb3349b0
https://doi.org/10.1021/jm4010835
https://doi.org/10.1021/jm4010835
Autor:
Jun Wang, JoAnne Stubbe, Guixue Yu, Kenichi Yokoyama, Galit Bar, Gregory J. S. Lohman, Erin Artin, Robert G. Griffin
Publikováno v:
Biochemistry. 48:11622-11629
Gemcitabine 5'-diphosphate (F(2)CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication and repair. The Escherichia coli RNR, an alpha2beta2 com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8935f3574b733d3eab711ff38c73d43f
https://doi.org/10.1021/bi901590q
https://doi.org/10.1021/bi901590q
Autor:
Ximao Wu, Guixue Yu, William R. Ewing, Yeheng Zhu, R. Michael Lawrence, Amarendra B. Mikkilineni, Jacques Y. Roberge
Publikováno v:
Scopus-Elsevier
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
ARKIVOC, Vol 2007, Iss 12, Pp 132-147 (2007)
Triazolopyridines and triazolopyrimidines were synthesized using a modified Mitsunobu reaction starting from acylated 2-hydrazinopyridines and acylated-hydrazinopyrimidines under mild conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f37e32e591deb9cc55a583871af4da
https://doi.org/10.3998/ark.5550190.0008.c10
https://doi.org/10.3998/ark.5550190.0008.c10
Autor:
Kenneth E. Carlson, Stephen G. Walker, Barry Koplowitz, Kathleen M. Gillooly, John W. Haycock, Kim W. McIntyre, Ximao Wu, Stephen Roberts, Guixue Yu, John E. Macor, George C. Morton, Huji Tuerdi, Yifan Yang, Timothy F. Herpin, R. Michael Lawrence, Liya Kang, Judy Wardwell-Swanson, Ashish Khanna
Publikováno v:
Journal of Leukocyte Biology. 80:897-904
It is well established that melanocortins are peptides that have potent anti-inflammatory activity. Recent research has focused on understanding which of the known melanocortin receptors mediates the anti-inflammatory actions of the melanocortins. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49eae78aadd18c8896ae186501df670d
https://doi.org/10.1189/jlb.1204748
https://doi.org/10.1189/jlb.1204748
Autor:
Carl Thibault, Gail K. Mattson, Macor John E, Graham S. Poindexter, Dan Shi, Guanglin Luo, Rejean Ruel, Helen Mason, Ruediger Edward H, Guixue Yu, Lawrence G. Iben, Alain Martel, Timothy F. Herpin, Ildiko Antal Zimanyi, Brigitte Poirier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4341-4344
β-Alanine derivative 2 (IC 50 =16 nM) and related compounds were found to be potent MC4R agonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803dc8ddd1e11c325a12e1f8a2a566e5
https://doi.org/10.1016/j.bmcl.2003.09.036
https://doi.org/10.1016/j.bmcl.2003.09.036
Autor:
Kenneth E. Carlson, John S. Tokarski, George C. Morton, R. Michael Lawrence, Guixue Yu, Huji Tuerdi, John E. Macor, Timothy F. Herpin, Ximao Wu, Liya Kang, Ashish Khanna
Publikováno v:
Journal of Medicinal Chemistry. 46:1123-1126
The melanocortin-1 receptor (MC-1R) is a G-protein-coupled receptor involved in inflammation and skin pigmentation. Compound 2 is the first highly potent and selective MC-1R small-molecule agonist reported. Compound 2 showed efficacy in an acute mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27cd19e9c4e3016d60a567ef90ee1f5
https://doi.org/10.1021/jm025600i
https://doi.org/10.1021/jm025600i
Autor:
Laurie Seliger, Jian Wang, Ronald Pongrac, Helen J. Mason, Bruce Beyer, Andrew Henwood, John Krupinski, Ximao Wu, John E. Macor, Saeho Chong, Rongan Zhang, Pam Ferrer, Diane E. Normandin, Guixue Yu, Leonard P. Adam, William G. Humphrey, Bin He
Publikováno v:
Journal of Medicinal Chemistry. 46:457-460
Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and selective PDE5 inhibitor than sildenafil (1). It is as efficacious as sildenafil in in vitro an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218be77cc0e567028fc0b4f6ba8b9bc2
https://doi.org/10.1021/jm0256068
https://doi.org/10.1021/jm0256068
Autor:
Ximao Wu, Helen J. Mason, Michael Witkus, John E. Macor, William R. Ewing, Guixue Yu, Kim Galdi, Ning Zhao, Cornelius Lyndon A M
Publikováno v:
Synthesis. 2003:0403-0407
Sulfuryl chloride has been used to mono-chlorinate electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids in a mild and efficient one-pot transformation with straightforward purification. Protection of the amines was not needed, and race
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87091f47c8b1447269493f97ce45b2e7
https://doi.org/10.1055/s-2003-37362
https://doi.org/10.1055/s-2003-37362
Publikováno v:
Tetrahedron Letters. 42:8931-8934
Hetero Diels–Alder reactions of heteroaromatic amidines and maleimide afforded novel fused pyridopyrrolidine dione scaffolds in moderate to good yields under mild conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede631966b1dd2c2e92ca92b6aeec8bb
https://doi.org/10.1016/s0040-4039(01)02000-7
https://doi.org/10.1016/s0040-4039(01)02000-7