Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Guipeng Li"'
Autor:
Qionghua Zhu, Xin Zhao, Yuanhang Zhang, Yanping Li, Shang Liu, Jingxuan Han, Zhiyuan Sun, Chunqing Wang, Daqi Deng, Shanshan Wang, Yisen Tang, Yaling Huang, Siyuan Jiang, Chi Tian, Xi Chen, Yue Yuan, Zeyu Li, Tao Yang, Tingting Lai, Yiqun Liu, Wenzhen Yang, Xuanxuan Zou, Mingyuan Zhang, Huanhuan Cui, Chuanyu Liu, Xin Jin, Yuhui Hu, Ao Chen, Xun Xu, Guipeng Li, Yong Hou, Longqi Liu, Shiping Liu, Liang Fang, Wei Chen, Liang Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-sequencing and ATAC-sequencing on 42
Externí odkaz:
https://doaj.org/article/4b07d25d53674d89ad35a9e3b196d071
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Antibody-mediated immune responses play a crucial role in the immune defense of human body. The evolution of bioengineering has led the progress of antibody-derived drugs, showing promising efficacy in cancer and autoimmune diseas
Externí odkaz:
https://doaj.org/article/9a103dbc8e0c417bac667efb7fe77024
Correlation between the Characteristic Flavour and Microbial Community of Xuanwei Ham after Ripening
Autor:
Guipeng Li, Simin Li, Yiling Wen, Jing Yang, Ping Wang, Huaiyao Wang, Yawen Cui, Wenliang Wu, Liang Li, Zhendong Liu
Publikováno v:
Fermentation, Vol 10, Iss 8, p 392 (2024)
Xuanwei ham is a traditional fermented meat product in China with a unique production process and excellent-quality reputation at home and abroad. To reveal the microbial community succession of Xuanwei ham at different post-ripening times (W1-4) and
Externí odkaz:
https://doaj.org/article/28d673694f634c04b2c585714d4e2bed
Autor:
Liang Fang, Guipeng Li, Zhiyuan Sun, Qionghua Zhu, Huanhuan Cui, Yunfei Li, Jingwen Zhang, Weizheng Liang, Wencheng Wei, Yuhui Hu, Wei Chen
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp 1-16 (2021)
Abstract Sample multiplexing facilitates single‐cell sequencing by reducing costs, revealing subtle difference between similar samples, and identifying artifacts such as cell doublets. However, universal and cost‐effective strategies are rather l
Externí odkaz:
https://doaj.org/article/ebc718c2af1444ad82d6c34afa66d132
Autor:
Liang Fang, Wen Wang, Guipeng Li, Li Zhang, Jun Li, Diwen Gan, Jiao Yang, Yisen Tang, Zewen Ding, Min Zhang, Wenhao Zhang, Daqi Deng, Zhengyu Song, Qionghua Zhu, Huanhuan Cui, Yuhui Hu, Wei Chen
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 11, Pp 1-10 (2020)
Abstract Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m6A and m5C, have been associated with critical cellular functions under physiological and/or pathological conditions. To understa
Externí odkaz:
https://doaj.org/article/d4a9ab8128004d33b73a402551a74d0e
Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation
Autor:
Yisheng Li, Bernhard Schaefke, Xudong Zou, Min Zhang, Florian Heyd, Wei Sun, Bin Zhang, Guipeng Li, Weizheng Liang, Yuhao He, Juexiao Zhou, Yunfei Li, Liang Fang, Yuhui Hu, Wei Chen
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 4, Pp 1-18 (2020)
Abstract Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. To clarify their functional relevance and evolution, we quantified allele‐specific APA pa
Externí odkaz:
https://doaj.org/article/364079b8ff864a828426fadbed806a72
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In diploid eukaryotic organisms, both alleles of each autosomal gene are usually assumed to be simultaneously expressed at similar levels. However, some genes can be expressed preferentially or strictly from a single allele, a process known as monoal
Externí odkaz:
https://doaj.org/article/87a472ff45be4edcab7c726bb743271a
Autor:
Xi Wang, Xintian You, Julian D. Langer, Jingyi Hou, Fiona Rupprecht, Irena Vlatkovic, Claudia Quedenau, Georgi Tushev, Irina Epstein, Bernhard Schaefke, Wei Sun, Liang Fang, Guipeng Li, Yuhui Hu, Erin M. Schuman, Wei Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
It is challenging to characterize diverse transcript isoforms by short-read sequencing. Here the authors report full-length transcriptomes in rat hippocampus by hybrid-sequencing, predict isoform-specific translational status, and reconstruct open re
Externí odkaz:
https://doaj.org/article/e648ad9d85e9487fb44af5a9caede55c
Autor:
Zhengyu Liang, Guipeng Li, Zejun Wang, Mohamed Nadhir Djekidel, Yanjian Li, Min-Ping Qian, Michael Q. Zhang, Yang Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Chromatin interactions and genome architecture are key regulators of gene expression. Here the authors present Bridge-Linker-Hi-C to map active chromatin loops and enhancer-promoter interactions.
Externí odkaz:
https://doaj.org/article/770153faabde43249cd319d518f6b96c
Autor:
Guipeng Li, Ming Li, Yiwei Zhang, Dong Wang, Rong Li, Roger Guimerà, Juntao Tony Gao, Michael Q Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94608 (2014)
Rapidly increasing amounts of (physical and genetic) protein-protein interaction (PPI) data are produced by various high-throughput techniques, and interpretation of these data remains a major challenge. In order to gain insight into the organization
Externí odkaz:
https://doaj.org/article/ea7cd2da31844636aa4546b9cebe1625