Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

Autor: Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are

Externí odkaz: https://doaj.org/article/2e185917117c4d43933d36f98b9d58b0

Glutarate regulates T cell function and metabolism

Autor: Eleanor Minogue, Pedro P. Cunha, Alessandro Quaranta, Javier Zurita, Shiv Sah Teli, Brennan J. Wadsworth, Rob Hughes, Guinevere L. Grice, Pedro Velica, David Bargiela, Laura Barbieri, Craig E. Wheelock, James A. Nathan, Peppi Koivunen, Iosifina P. Foskolou, Randall S. Johnson

T cell function is influenced by several metabolites; some acting through enzymatic inhibition of α-KG-dependent dioxygenases (αKGDDs), others, through post-translational modification of lysines in important targets. We show here that glutarate, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::538efc706f989d5ebc17f27fe7005cec
https://doi.org/10.1101/2022.10.20.513065

Critical care workers have lower seroprevalence of SARS-CoV-2 IgG compared with non-patient facing staff in first wave of COVID19

Autor: Rainer Doffinger, Jonathan L. Heeney, S. Pai, J. Gronlund, Leo C. James, A. Sayer, John A. G. Briggs, Soraya Ebrahimi, Helen Baxendale, James A. Nathan, Lourdes Ceron-Gutierrez, Xiaoli Xiong, Jakub Luptak, Paul Tonks, M. Paloniemi, Angalee Nadesalingam, David A. Wells, Guinevere L. Grice, George Carnell

With the first 2020 surge of the COVID-19 pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams to look after high numbers of patients with severe COVID-19. There was considerable anxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38569d413671ad0422358d6e87147fe0

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

Autor: Anna L. Miles, James A. Nathan, Guinevere L. Grice, Stephen P. Burr

Publikováno v: eLife, Vol 6 (2017)
eLife

Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation. Observations that HIF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cc8c136ee63de8c01507f933c7452
https://www.repository.cam.ac.uk/handle/1810/264424

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

Autor: James A. Nathan, Gordon Dougan, Dick J. H. van den Boomen, Paul J. Lehner, Richard T. Timms, Guinevere L. Grice, Karsten Skødt, Helen R. Stagg

Publikováno v: van den Boomen, D J H, Timms, R T, Grice, G L, Stagg, H R, Dougan, G, Nathan, J A, Lehner, P J & Skjødt, K 2014, ' TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 31, pp. 11425–11430 . https://doi.org/10.1073/pnas.1409099111

The US11 gene product of human cytomegalovirus promotes viral immune evasion by hijacking the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. US11 initiates dislocation of newly translocated MHC I from the ER to the cytosol for prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e0053047f365b267299230656ffb99
https://doi.org/10.1073/pnas.1409099111