Single-entity heparan sulfate glycomimetic clusters for therapeutic applications

Autor: Tyler, Peter, Guimond, SE, Turnbull, JE, Zubkova, Olga

Heparan sulfate (HS) is a highly sulfated glycosaminoglycan with a variety of critical functions in cell signaling and regulation. HS oligosaccharides can mimic or interfere with HS functions in biological systems; however, their exploitation has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62de6814d0ec786250710b80266bc0c3

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1).

Autor: Mycroft-West CJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: courtney.mycroft-west@rfi.ac.uk., Devlin AJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy. Electronic address: anthony.devlin@rfi.ac.uk., Cooper LC; University of Gloucestershire, Francis Close Hall Campus, Swindon Rd, Cheltenham, GL50 4AZ, UK. Electronic address: lcooper1@glos.ac.uk., Guimond SE; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: s.e.guimond@keele.ac.uk., Procter P; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: p.procter@keele.ac.uk., Miller GJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: g.j.miller@keele.ac.uk., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy. Electronic address: guerrini@ronzoni.it., Fernig DG; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: dgfernig@liverpool.ac.uk., Yates EA; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: E.A.Yates@liverpool.ac.uk., Lima MA; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: m.andrade.de.lima@keele.ac.uk., Skidmore MA; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: m.a.skidmore@keele.ac.uk.

Publikováno v: Carbohydrate research [Carbohydr Res] 2023 Mar; Vol. 525, pp. 108747. Date of Electronic Publication: 2023 Jan 26.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.

Autor: Guimond SE; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Mycroft-West CJ; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Gandhi NS; School of Chemistry and Physics, Centre for Genomics and Personalized Health, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia., Tree JA; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Le TT; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Spalluto CM; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom., Humbert MV; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom., Buttigieg KR; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Coombes N; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Elmore MJ; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Wand M; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom., Nyström K; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Said J; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Setoh YX; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Amarilla AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Modhiran N; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Sng JDJ; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Chhabra M; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Young PR; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Rawle DJ; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Lima MA; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Yates EA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom., Karlsson R; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Chen YH; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Bagdonaite I; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Yang Z; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark., Stewart J; Department of Infection Biology & Microbiomes, University of Liverpool, Liverpool L69 7ZB, United Kingdom., Nguyen D; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Laidlaw S; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Hammond E; Zucero Therapeutics Ltd, 1 Westlink Court, Brisbane, Queensland 4076, Australia., Dredge K; Zucero Therapeutics Ltd, 1 Westlink Court, Brisbane, Queensland 4076, Australia., Wilkinson TMA; School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton SO17 1BJ, United Kingdom.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, United Kingdom., Watterson D; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Khromykh AA; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Suhrbier A; QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia., Carroll MW; National Infection Service, UK Health Security Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom., Trybala E; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Bergström T; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Guldhedsgatan 10B, S-413 46 Goteborg, Sweden., Ferro V; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia.; Australian Infectious Diseases Research Centre, GVN Center of Excellence, Brisbane, Queensland 4072/4079, Australia., Skidmore MA; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom., Turnbull JE; Centre for Glycoscience, School of Life Sciences, Keele University, Newcastle-Under-Lyme, Staffordshire ST5 5BG, United Kingdom.; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.; Copenhagen Center for Glycomics, Department of Cellular & Molecular Medicine, University of Copenhagen, Copenhagen N 2200, Denmark.

Publikováno v: ACS central science [ACS Cent Sci] 2022 May 25; Vol. 8 (5), pp. 527-545. Date of Electronic Publication: 2022 Mar 29.

Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1.

Autor: Mycroft-West CJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Devlin AJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Cooper LC; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Guimond SE; School of Medicine, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Procter P; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133 Milan, Italy., Miller GJ; School of Chemistry, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Fernig DG; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK., Yates EA; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK., Lima MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Skidmore MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK.; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.

Publikováno v: Marine drugs [Mar Drugs] 2021 Apr 03; Vol. 19 (4). Date of Electronic Publication: 2021 Apr 03.

Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities.

Autor: Ní Cheallaigh A; Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK; Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland., Guimond SE; School of Medicine, Keele University, Keele, Staffordshire, ST5 5BG, UK., Oscarson S; Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland., Miller GJ; Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: g.j.miller@keele.ac.uk.

Publikováno v: Carbohydrate research [Carbohydr Res] 2020 Sep; Vol. 495, pp. 108085. Date of Electronic Publication: 2020 Jul 12.