Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Guilong Cheng"'
Publikováno v:
Magnetic Resonance in Chemistry. 60:157-164
An impurity, designated MS204, was isolated from a scale-up production of an intermediate toward the synthesis of an active pharmaceutical ingredient. Structural elucidation of this chloro-containing impurity was performed based on the analysis of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a923119969b839b337c636726ce5c96
https://doi.org/10.1002/mrc.5204
https://doi.org/10.1002/mrc.5204
Publikováno v:
Magnetic resonance in chemistry : MRCREFERENCES. 60(1)
An impurity, designated MS204, was isolated from a scale-up production of an intermediate toward the synthesis of an active pharmaceutical ingredient. Structural elucidation of this chloro-containing impurity was performed based on the analysis of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc2fb70107b09beb77ac8bc002647c34
https://pubmed.ncbi.nlm.nih.gov/34376016
https://pubmed.ncbi.nlm.nih.gov/34376016
Autor:
Christine Nowak, Adriana Kita, Hongcheng Liu, Guilong Cheng, Gomathinayagam Ponniah, Alyssa Neill, Yekaterina Kori
Publikováno v:
Analytical Biochemistry. 496:4-8
Light exposure is one of several conditions used to study the degradation pathways of recombinant monoclonal antibodies. Tryptophan is of particular interest among the 20 amino acids because it is the most photosensitive. Tryptophan degradation forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619825c934b1361ef1819712dec8d632
https://doi.org/10.1016/j.ab.2015.12.004
https://doi.org/10.1016/j.ab.2015.12.004
Publikováno v:
TrAC Trends in Analytical Chemistry. 49:89-99
Drug degradation prediction, chemical-based experiments, isolation and structure-elucidation techniques are all tools used to develop drug candidates. Structure elucidation often requires isolation, degradation chemistry, mass spectrometry and nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2990b502b42ee7c4487e281eb4b9f4
https://doi.org/10.1016/j.trac.2013.06.005
https://doi.org/10.1016/j.trac.2013.06.005
Autor:
David Fortin, Guilong Cheng, Gang Xue, George L. Reid, James E. Morgado, Jian Wang, Jeffrey W. Harwood
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 36:2612-2638
The Analytical Quality by Design (AQbD) concept is demonstrated in the development of a stability-indicating HPLC method for an immediate release dosage form. The AQbD workflow is discussed and demonstrated with a systematic three stage liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc93f673fba8d2d5832dda08b15e3d84
https://doi.org/10.1080/10826076.2013.765457
https://doi.org/10.1080/10826076.2013.765457
Autor:
Guilong Cheng, Herbert H. Hill, Xing Zhang, Kristyn M. Roscioli, William F. Siems, Zhongli Zhang, Gilles H. Goetz, Shelly X. Li
Publikováno v:
International Journal of Mass Spectrometry. 336:27-36
Reaction monitoring is a critical step in the synthesis of new drug entities, and many pharmaceutical companies spend significant resources on equipment and new methods to perform this task. The potential of electrospray ion mobility-mass spectrometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1900a5eb03e055304b4b7a27cdcf2a9
https://doi.org/10.1016/j.ijms.2012.12.004
https://doi.org/10.1016/j.ijms.2012.12.004
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 55:569-573
Axitinib (AG-013736) is a potent investigational drug that has antitumor activity in patients with metastatic renal cell carcinoma and other types of cancers. In this study, ion mobility spectrometry and "direct analysis in real time" (DART™) mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46c8399d3f4bcc56601835e57c65f2a
https://doi.org/10.1016/j.jpba.2011.02.021
https://doi.org/10.1016/j.jpba.2011.02.021
Autor:
Gomathinayagam Ponniah, Yekaterina Kori, Adriana Kita, Guilong Cheng, Hongcheng Liu, Christine Nowak
Publikováno v:
Analytical biochemistry. 497
Limited proteolytic digestion is a method with a long history that has been used to study protein domain structures and conformational changes. A method of combining limited proteolytic digestion, stable isotope labeling, and mass spectrometry was es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0feb116129230e814311d7af22a41f
https://pubmed.ncbi.nlm.nih.gov/26747642
https://pubmed.ncbi.nlm.nih.gov/26747642
Publikováno v:
Organometallics. 22:1468-1474
Iron(II) meso-tetraphenylporphyrin is an efficient catalyst for the selective olefination of a variety of aromatic and aliphatic aldehydes with use of ethyl diazoacetate in the presence of triphenylphosphine. These reactions gave olefin products in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63a45671b32f821500f9b3dac88c082
https://doi.org/10.1021/om020904o
https://doi.org/10.1021/om020904o