Výsledky vyhledávání - "Guillherme Pereira"

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Autor: Guillherme Pereira, Michael Morgan, Yin Liang, Tawfik Gharbaoui, Robert M. Jones, Fioravanti Beatriz, Charles Xing, Karoline Choi, Hussien A. Al-Shamma, Carleton R. Sage, Albert S. Ren, Graeme Semple, James N. Leonard, Young-Jun Shin, Andrew J. Grottick, Yifeng Xiong, Zhi-Liang Chu, Imelda Calderon, Keith T. Demarest

Publikováno v: Bioorganicmedicinal chemistry letters. 21(10)

We herein outline the design of a new series of agonists of the pancreatic and GI-expressed orphan G-protein coupled receptor GPR119, a target that has been of significant recent interest in the field of metabolism, starting from our prototypical ago

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789deaaaae2919e5420c881235632765
https://pubmed.ncbi.nlm.nih.gov/21444206

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Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119

Publikováno v: Journal of medicinal chemistry. 51(17)

GPR119 is a rhodopsin-like GPCR expressed in pancreatic beta-cells and incretin releasing cells in the GI tract. As with incretins, GPR119 increases cAMP levels in these cell types, thus making it a highly attractive potential target for the treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbef2e826177334fa773b7ecb0ed9d28
https://pubmed.ncbi.nlm.nih.gov/18698756

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Akademický článek

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119.

Publikováno v: Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 17, p5172-5175, 4p

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