Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Guillermo Sastre-Moreno"'
1
Akademický článek
Yeast pol4 promotes tel1-regulated chromosomal translocations.
Autor: Jose F Ruiz, Benjamin Pardo, Guillermo Sastre-Moreno, Andrés Aguilera, Luis Blanco
Publikováno v: PLoS Genetics, Vol 9, Iss 7, p e1003656 (2013)
DNA double-strand breaks (DSBs) are one of the most dangerous DNA lesions, since their erroneous repair by nonhomologous end-joining (NHEJ) can generate harmful chromosomal rearrangements. PolX DNA polymerases are well suited to extend DSB ends that
Externí odkaz: https://doaj.org/article/860063a05b7e4982a79cba0b6bea4824
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2
Polμ tumor variants decrease the efficiency and accuracy of NHEJ
Autor: Alberto Díaz-Talavera, Luis Blanco, John M. Pryor, José F. Ruiz, Dale A. Ramsden, Guillermo Sastre-Moreno
Publikováno v: Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment of the broken ends, a complex task performed in human cells by two specialized DNA polymerases, P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d395f871764512248c30fddb21ca4dd5
https://doi.org/10.1093/nar/gkx625
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3
The invariant glutamate of human PrimPol DxE motif is critical for its Mn2+-dependent distinctive activities
Autor: María I. Martínez-Jiménez, Cristina Perpiñá, Luis Blanco, Patricia A. Calvo, Susana Guerra, Guillermo Sastre-Moreno
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
PrimPol is a human primase/polymerase specialized in downstream repriming of stalled forks during both nuclear and mitochondrial DNA replication. Like most primases and polymerases, PrimPol requires divalent metal cations, as Mg2+ or Mn2+, used as co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21e0be56b77c90e44bcde7dca15332d
http://hdl.handle.net/10261/246714
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4
A cancer-associated point mutation disables the steric gate of human PrimPol
Autor: Patricia A. Calvo, Daniel González-Acosta, Marcos Díaz, Juan Méndez, Alberto Díaz-Talavera, María I. Martínez-Jiménez, Susana Guerra, Guillermo Sastre-Moreno, Luis Blanco, Luis Blanco-Franco
Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
PrimPol is a human primase/polymerase specialized in re-starting stalled forks by repriming beyond lesions such as pyrimidine dimers, and replication-perturbing structures including G-quadruplexes and R-loops. Unlike most conventional primases, PrimP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11e638af8e6b5ba8a73bca8c54e2000
http://europepmc.org/articles/PMC6362072
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5
Regulation of human Polλ by ATM-mediated phosphorylation during Non-Homologous End Joining
Autor: José F. Ruiz, Luis Blanco, Dale A. Ramsden, Marta Moreno-Oñate, Andrés Herrero-Ruiz, Felipe Cortés-Ledesma, Guillermo Sastre-Moreno, John M. Pryor
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage response (DDR), that are primarily regulated by protein kinase ataxia-telangiectasia mutated (ATM). Among DDR activated processes, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13786f9c8294c351d640ddc29c42515
https://europepmc.org/articles/PMC5444907/
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6
ATP insertion opposite 8-oxo-deoxyguanosine by Pol4 mediates error-free tolerance in Schizosaccharomyces pombe
Autor: Guillermo Sastre-Moreno, Verónica Esteban, A. Sanchez, Luis Blanco
Publikováno v: Nucleic Acids Research
7,8-Dihydro-8-oxo-deoxyguanosine (8oxodG) is a highly premutagenic DNA lesion due to its ability to mispair with adenine. Schizosaccharomyces pombe lacks homologs for relevant enzymes that repair 8oxodG, which suggests that this lesion could be persi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6cabaa6981aaac72b6e587d13322f0
http://europepmc.org/articles/PMC4150805
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7
Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol
Autor: Katarzyna Bebenek, Patricia A. Calvo, María I. Martínez-Jiménez, Guillermo Sastre-Moreno, Sara García-Gómez, Luis Blanco, Alberto Díaz-Talavera, Thomas A. Kunkel
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
© 2015 Elsevier B.V. PrimPol is a recently described DNA polymerase that has the virtue of initiating DNA synthesis. In addition of being a sensu stricto DNA primase, PrimPol's polymerase activity has a large capacity to tolerate different kind of l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb8852e55f221657fe9f4d52390f65
http://hdl.handle.net/10261/133183
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8
Yeast pol4 promotes tel1-regulated chromosomal translocations
Autor: Benjamin Pardo, Guillermo Sastre-Moreno, José F. Ruiz, Andrés Aguilera, Luis Blanco
Publikováno v: PLoS Genetics, Vol 9, Iss 7, p e1003656 (2013)
PLoS Genetics
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
DNA double-strand breaks (DSBs) are one of the most dangerous DNA lesions, since their erroneous repair by nonhomologous end-joining (NHEJ) can generate harmful chromosomal rearrangements. PolX DNA polymerases are well suited to extend DSB ends that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc9a6258d511f123d31c9f0db13e3e3
http://europepmc.org/articles/PMC3715435?pdf=render
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