Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss

Autor: Lisa Willemsen, Annette E Neele, Saskia van der Velden, Koen H M Prange, Myrthe den Toom, Cindy P A A van Roomen, Myrthe E Reiche, Guillermo R Griffith, Marion J J Gijbels, Esther Lutgens, Menno P J de Winther

Publikováno v: BMJ Open Diabetes Research & Care, Vol 7, Iss 1 (2019)

Introduction Obesity is recognized as a risk factor for various microbial infections. The immune system, which is affected by obesity, plays an important role in the pathophysiology of these infections and other obesity-related comorbidities. Weight

Externí odkaz: https://doaj.org/article/42a8071b1f924035ab50a83a567d6da6

Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Autor: Karl J. Harber, Annette E. Neele, Cindy PAA. van Roomen, Marion JJ. Gijbels, Linda Beckers, Myrthe den Toom, Bauke V. Schomakers, Daan AF. Heister, Lisa Willemsen, Guillermo R. Griffith, Kyra E. de Goede, Xanthe AMH. van Dierendonck, Myrthe E. Reiche, Aurélie Poli, Frida L-H Mogensen, Alessandro Michelucci, Sanne GS. Verberk, Helga de Vries, Michel van Weeghel, Jan Van den Bossche, Menno PJ. de Winther

Publikováno v: Redox Biology, Vol 70, Iss , Pp 103054- (2024)

Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be

Externí odkaz: https://doaj.org/article/7cec2f81eb784b929ea89dd94752aa37

Monocyte and Macrophage Lipid Accumulation Results in Down-Regulated Type-I Interferon Responses

Autor: Lisa Willemsen, Hung-Jen Chen, Cindy P. A. A. van Roomen, Guillermo R. Griffith, Ricky Siebeler, Annette E. Neele, Jeffrey Kroon, Marten A. Hoeksema, Menno P. J. de Winther

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammatory activat

Externí odkaz: https://doaj.org/article/69458ffd899140378f46c0bb4e3955bd

Identification of New Drugs to Counteract Anti-Spike IgG-Induced Hyperinflammation in Severe COVID-19

Autor: Chiara E. Geyer, Hung-Jen Chen, Alexander P. Bye, Xue D. Manz, Denise Guerra, Tom G. Caniels, Tom PL Bijl, Guillermo R. Griffith, Willianne Hoepel, Steven W. de Taeye, Jennifer Veth, Alexander P. J. Vlaar, Amsterdam anon, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M. Gibbins, Marit J. van Gils, Menno de Winther, Jeroen den Dunnen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::460f9952ca5e13fbd45854e10150a19b
https://doi.org/10.2139/ssrn.4327343

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Autor: Korneliusz Golebski, Federica Linty, Harm Jan Bogaard, Guillermo R. Griffith, Godelieve J. de Bree, Marit J. van Gils, Willianne Hoepel, Tom G. Caniels, Lynn Mes, Hung-Jen Chen, Frank E.H.P. van Baarle, Cornelis M. van Drunen, René E. Jonkers, Jurjan Aman, Sona Allahverdiyeva, Menno P.J. de Winther, Jeroen den Dunnen, Karlijn van der Straten, Manfred Wuhrer, Mads Delbo Larsen, Gestur Vidarsson, Jan Nouta, Rogier W. Sanders, Theo Rispens, Alexander P.J. Vlaar, Maurice Steenhuis, Gertjan Wolbink, Diederik van de Beek, Philip J. M. Brouwer, Xue D. Manz, Cindy P. A. A. van Roomen, Peter I. Bonta, Chiara Elisabeth Geyer, Annette E. Neele, Lisa Willemsen, Steven W. de Taeye

Publikováno v: Science Translational Medicine, 13(596):eabf8654. American Association for the Advancement of Science
Hoepel, W, Chen, H-J, Geyer, C E, Allahverdiyeva, S, Manz, X D, de Taeye, S W, Aman, J, Mes, L, Steenhuis, M, Griffith, G R, Bonta, P I, Brouwer, P J M, Caniels, T G, van der Straten, K, Golebski, K, Jonkers, R E, Larsen, M D, Linty, F, Nouta, J, van Roomen, C P A A, van Baarle, F E H P, van Drunen, C M, Wolbink, G, Vlaar, A P J, de Bree, G J, Sanders, R W, Willemsen, L, Neele, A E, van de Beek, D, Rispens, T, Wuhrer, M, Bogaard, H J, van Gils, M J, Vidarsson, G, de Winther, M & den Dunnen, J 2021, ' High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages ', Science Translational Medicine, vol. 13, no. 596, eabf8654 . https://doi.org/10.1126/scitranslmed.abf8654
Science Translational Medicine
Science Translational Medicine, 13(596). AMER ASSOC ADVANCEMENT SCIENCE
Science translational medicine, 13(596):eabf8654. American Association for the Advancement of Science

High titers and low fucosylation of human anti-spike protein IgG promote alveolar macrophage activation and inflammation.
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3776bc2b7ca6cf18e6e8c677efa6c2a
https://research.vumc.nl/en/publications/9c41a896-d9c0-4ca8-a875-c845ffd899e8