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pro vyhledávání: '"Guillermo M Gomez"'
Autor:
Guillermo M Gomez, Giulia D'Arrigo, Cecilia P Sanchez, Fiona Berger, Rebecca C Wade, Michael Lanzer
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011436 (2023)
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug histories driving its evolution and, hence, the drug transport specificitie
Externí odkaz:
https://doaj.org/article/4dfce052391d4bef93bf212ea18e6e8b
Autor:
Fiona Berger, Guillermo M. Gomez, Cecilia P. Sanchez, Britta Posch, Gabrielle Planelles, Farzin Sohraby, Ariane Nunes-Alves, Michael Lanzer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The chloroquine resistance transporter, PfCRT, of the human malaria parasite Plasmodium falciparum is sensitive to acidic pH. Consequently, PfCRT operates at 60% of its maximal drug transport activity at the pH of 5.2 of the digestive vacuol
Externí odkaz:
https://doaj.org/article/4481fd0850c543e2a8b0bb81ca74a0e9