Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Guillermo M, Alexander"'
Autor:
Guillermo M. Alexander, Terry D. Heiman-Patterson, Frank Bearoff, Roger B. Sher, Laura Hennessy, Shannon Terek, Nicole Caccavo, Gregory A. Cox, Vivek M. Philip, Elizabeth A. Blankenhorn
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5–10% of cases are familial, with mutations associated with over 40 genes. There is variation of ALS symptoms within
Externí odkaz:
https://doaj.org/article/c5e45c28b7ff4ee8a44b61046dc065b0
Autor:
Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan, Seena K. Ajit
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background Therapeutic plasma exchange (PE) or plasmapheresis is an extracorporeal procedure employed to treat immunological disorders. Exosomes, nanosized vesicles of endosomal origin, mediate intercellular communication by transferring car
Externí odkaz:
https://doaj.org/article/fb344a0242974c5190bca45c06a856f0
Autor:
Sujay Ramanathan, Botros B. Shenoda, Zhucheng Lin, Guillermo M. Alexander, Arthur Huppert, Ahmet Sacan, Seena K. Ajit
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular RNA in circulation mediates intercellular communication in normal and pathological processes. One mode of circulating miRNA transport in bodily fluids is within 30–150 nm small extracellular vesicles (sEVs) or exosomes. Uptake of sEVs
Externí odkaz:
https://doaj.org/article/3284fb1ba3ef488da53daebc86b9aded
Autor:
Lindsey R. Fischer, Deborah G. Culver, Albert A. Davis, Philip Tennant, Minsheng Wang, Michael Coleman, Seneshaw Asress, Robert Adalbert, Guillermo M. Alexander, Jonathan D. Glass
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 293-300 (2005)
The “slow Wallerian degeneration” (WldS) gene is neuroprotective in numerous models of axonal degeneration. Axonal degeneration is an early feature of disease progression in the SOD1G93A mouse, a widely used model of familial amyotrophic lateral
Externí odkaz:
https://doaj.org/article/13be9544346a497092844024b6a267f8
Autor:
Botros B. Shenoda, Richa Pande, Sujay Ramanathan, Guillermo M. Alexander, Robert J. Schwartzman, Seena K. Ajit, Ayush A. Parikh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss, Pp 111788-(2021)
Biomed Pharmacother
Biomed Pharmacother
Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by inflammation and debilitating pain. CRPS patients with pain refractory to more conventional analgesics can be treated with subanesthetic doses of ketamine. Our previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f23bbf77dd46a0f3c50e58f912cbe1
http://www.sciencedirect.com/science/article/pii/S0753332221005709
http://www.sciencedirect.com/science/article/pii/S0753332221005709
Autor:
Terry D Heiman-Patterson, Elizabeth P Blankenhorn, Roger B Sher, Juliann Jiang, Priscilla Welsh, Meredith C Dixon, Jeremy I Jeffrey, Philip Wong, Gregory A Cox, Guillermo M Alexander
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0117848 (2015)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons in the central nervous system. Although most cases of ALS are sporadic, about 5-10% of cases are familial (FALS) with approximately 20% of FALS cause
Externí odkaz:
https://doaj.org/article/f15da2421d78404091f24e11313c9f4d
Autor:
Jeffrey S Deitch, Guillermo M Alexander, Andrew Bensinger, Steven Yang, Juliann T Jiang, Terry D Heiman-Patterson
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99879 (2014)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor neuron. While most cases of ALS are sporadic, 10% are familial (FALS) with 20% of FALS caused by a mutation in the gene that codes for the enzyme Cu/Zn supero
Externí odkaz:
https://doaj.org/article/01ab346572ff4e9181fb5379e82c9ab9
Autor:
Gerardo Morfini, Lanfranco Leo, Guillermo M. Alexander, Hemalatha Muralidharan, Michelle Swift, Terry Heiman-Patterson, Laura E Hennessy, Liang Qiang, Emanuela Piermarini, Peter W. Baas, Wenqian Yu, Philip L Yates, Michael A. Lane, Theresa Connors, Lyandysha V. Zholudeva, Silvia Fernandes
Publikováno v:
Human Molecular Genetics. 28:1136-1152
Mutations of the SPAST gene, which encodes the microtubule-severing protein spastin, are the most common cause of hereditary spastic paraplegia (HSP). Haploinsufficiency is the prevalent opinion as to the mechanism of the disease, but gain-of-functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392288552928dc5ee37a2ed8f926b06e
https://doi.org/10.1093/hmg/ddy419
https://doi.org/10.1093/hmg/ddy419
Autor:
Zhucheng Lin, Arthur Huppert, Ahmet Sacan, Seena K. Ajit, Botros B. Shenoda, Sujay Ramanathan, Guillermo M. Alexander
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles
Extracellular RNA in circulation mediates intercellular communication in normal and pathological processes. One mode of circulating miRNA transport in bodily fluids is within 30–150 nm small extracellular vesicles (sEVs) or exosomes. Uptake of sEVs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6dcca83cd5fe36d20729a5e4271d76
https://doaj.org/article/3284fb1ba3ef488da53daebc86b9aded
https://doaj.org/article/3284fb1ba3ef488da53daebc86b9aded
Autor:
Ahmet Sacan, Yuzhen Tian, Srinivas Somarowthu, Botros B. Shenoda, Seena K. Ajit, Renee Jean-Toussaint, Richa Gupta, Sankar Addya, Guillermo M. Alexander, Sujay Ramanathan
Publikováno v:
Cell Mol Life Sci
Biological sex influences inflammatory response, as there is a greater incidence of acute inflammation in men and chronic inflammation in women. Here, we report that acute inflammation is attenuated by X-inactive specific transcript (Xist), a female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04d2164b0e3bf4b4a9fc9c9e3ff69e5
https://pubmed.ncbi.nlm.nih.gov/32193609
https://pubmed.ncbi.nlm.nih.gov/32193609