First-line osimertinib in patients with epidermal growth factor receptor–mutant non–small-cell lung cancer and with a coexisting low allelic fraction of Thr790Met

Autor: Griselda Martrat, Jorge García-González, Guillermo Lopez-Vivanco, Santiago Viteri, J. Garde, Manuel Cobo, Miguel Sampayo, Rafael Rosell, Jose Miguel Sanchez, Niki Karachaliou, Ivanna Sullivan, Miguel Angel Molina-Vila, Andrea Malfettone, Margarita Majem

Publikováno v: European Journal of Cancer. 159:174-181

Aim of the study The AZENT ( NCT02841579 ) study aimed to assess the efficacy and safety of first-line osimertinib in patients with epidermal growth factor receptor(EGFR)mutation–positive advanced non–small-cell lung cancer (NSCLC) and with a coe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e059522ad9ce5f5617d1c5168d5485
https://doi.org/10.1016/j.ejca.2021.09.039

Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy

Autor: Alex Martinez-Marti, Edwin R. Parra, Bartomeu Massuti, Manuel Domine, Manuel Cobo, M. Lázaro, Nuria Viñolas, Pedro Rocha, Edel del Barco, Guillermo Lopez-Vivanco, Reyes Bernabe Caro, Miguel Barquín, Mariano Provencio, Santiago Viteri, Raquel Laza-Briviesca, Belén Sierra-Rodero, Alberto Cruz-Bermúdez, Ignacio I. Wistuba, Isidoro Barneto Aranda, Amelia Insa, Humam Kadara, Maria Rosario Garcia Campelo, Margarita Majem, M. Casarrubios, Delvys Rodriguez-Abreu, Ernest Nadal, Beatriz Sanchez-Espiridion, Javier de Castro-Carpeño, Virginia Calvo, Atocha Romero

Publikováno v: Scientia
CLINICAL CANCER RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

Purpose:Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non–small cell lung cancer (NSCLC).Experimental Design:In this study, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11b82f4b306b4189ff496fe2d1850a3
https://pubmed.ncbi.nlm.nih.gov/34376534

Abstract 560: High levels of baseline ctDNA constitute a poor prognostic factor in progression-free survival in patients receiving neo-adjuvant chemo-immunotherapy: Results from NADIM clinical trial

Autor: Atocha Romero, Ana Royuela, Alex Martinez-Marti, E. Pereira, Manuel Cobo, Manuel Domine, Nuria Viñolas, R. Bernabé, Edel del Barco, Diego Pereiro Corbacho, M. Casarrubios, Alberto Cruz-Vermudez, Guillermo Lopez-Vivanco, Isidoro Barneto, Mariano Provencio, Amelia Insa, Santiago Viteri, Bartomeu Massuti, Roberto Serna-Blasco, Virginia Calvo, Ignacio I. Wistuba, Clara Salas, Javier de Castro, Delvys Rodriguez-Abreu, Margarita Majem, Edwin R. Parra, Ernest Nadal, M. Rosario Garcia-Campelo, Raquel Laza-Briviesca

Publikováno v: Cancer Research. 81:560-560

There is growing evidence supporting that long-term survival of neoadjuvant chemo-immunotherapy for locally advanced NSCLC patients can be achieved. However, some patients invariably progress within the short-term. Identification of patients at high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e8c220f81ea2f784a0bb49907b49975
https://doi.org/10.1158/1538-7445.am2021-560

Association of PALB2 Messenger RNA Expression with Platinum-Docetaxel Efficacy in Advanced Non-Small Cell Lung Cancer

Autor: Manuel Domine, Jillian Wilhelmina Paulina Bracht, Guillermo Lopez-Vivanco, Mariano Provencio, Imane Chaib, Manuel Cobo, Bartomeu Massuti, Ana Drozdowskyj, Margarita Majem, Niki Karachaliou, Manuel Fernandez Bruno, Alain Vergnenegre, Enric Carcereny, Carlos Camps, Jose Luis Ramirez, Rafael Rosell, Ana Gimenez Capitan, Teresa Moran

Publikováno v: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia
instname
JOURNAL OF THORACIC ONCOLOGY
r-FISABIO. Repositorio Institucional de Producción Científica
Journal of Thoracic Oncology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

Introduction: Partner and localizer of BRCA2 (PALB2) is essential for homologous recombination repair. We examined mRNA levels of DNA repair genes, including partner and localizer of BRCA2 gene (PALB2), ring finger protein 8 gene (RNF8), replication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b3349c7eb2654f6879639295a75fbc
https://fundanet.fihgu.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1376

Long-term response to first-line bevacizumab-based therapy in patients with metastatic breast cancer: results of the observational LORENA study

Autor: Jose Ignacio Chacon, Miguel Gil, Elisa Garcia-Garre, Isabel Garau Llinas, Guillermo Lopez-Vivanco, Luis Manso, Manuel Ramos Vazquez, Andrés Redondo, César A. Rodríguez

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Background: Randomized controlled trials of the first-line combination of bevacizumab and chemotherapy in patients with metastatic breast cancer (MBC) have shown improvements in tumor response and progression-free survival (PFS). Objective: The aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ac9cea45a60f68be5e33b3b5ae618d
https://doi.org/10.2147/ott.s170303