In vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep

Autor: Guillermo Leon Virkel, Carlos Lanusse, Paula Viviani, Lívio Martins Costa, Victoria Miró, Adrian Luis Lifschitz, Carolina Rocha

Publikováno v: Xenobiotica. 50:408-414

Combinations of bioactive phytochemicals with synthetic compounds have been suggested as promissory tools for the improvement of nematode control in livestock. Bioactive phytochemicals may interfere with the activity of drug-metabolizing enzymes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6e9a258c7826c125109ba93cb02804
https://doi.org/10.1080/00498254.2019.1644390

Plant-derived compounds as a tool for the control of gastrointestinal nematodes: Modulation of abamectin pharmacological action by carvone

Autor: S. Luque, María Victoria Miró, D. M. Sousa, Mercedes Lloberas, A. M. S. Soares, Guillermo Leon Virkel, Adrian Luis Lifschitz, Lívio Martins Costa-Júnior, Patricia Alejandra Cardozo

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Veterinary Science
Frontiers in Veterinary Science, Vol 7 (2020)

The combination of synthetic anthelmintics and bioactive phytochemicals may be a pharmacological tool for improving nematode control in livestock. Carvone (R-CNE) has shown in vitro activity against gastrointestinal nematodes; however, the anthelmint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2def4290cc3e6dd11e32abf618169e
https://www.frontiersin.org/articles/10.3389/fvets.2020.601750/full

Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism

Autor: Guillermo Leon Virkel, Lívio Martins Costa-Júnior, Adrian Luis Lifschitz, Matheus Nobate Gomes, Victoria Miró, Isabella Chaves Sousa, Caio Pavão Tavares

Publikováno v: Ticks and Tick-borne Diseases. 13:101874

The cattle tick Rhipicephalus microplus is one of the most important ectoparasites in the tropical and subtropical regions of the world. Synthetic pyrethroids are widely used to control this tick, and the selection of resistant populations is a huge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80064a01e9825b2aa2b4d8a1aaa20fe5
https://doi.org/10.1016/j.ttbdis.2021.101874

Species differences in hepatic biotransformation of the anthelmintic drug flubendazole

Autor: María Laura Maté, Charles D. Mackenzie, Timothy G. Geary, Guillermo Leon Virkel, Carlos Edmundo Lanusse

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic used in pigs, poultry, and humans. It has been proposed as a candidate for development for use in elimination programmes for lymphatic filariasis and onchocerciasis in humans. Moreove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b07907b2284fefcd360f08f5399a2c
https://doi.org/10.1111/jvp.12383

Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum

Autor: Guillermo Leon Virkel, Laura Moreno, Luis Alvarez, Gabriela Cadenazzi, Laura Ceballos, Candela Canton, Paula Dominguez, Carlos Edmundo Lanusse

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Ascaris suum is a widespread parasitic nematode that causes infection in pigs with high prevalence rates. Oxfendazole (OFZ) is effective against A. suum when used at a single high oral dose of 30 mg/kg. The aim of this study was to assess the pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7997d89c1a8bb472b863a459f6b376b
https://www.sciencedirect.com/science/article/abs/pii/S0014489418304843