Výsledky vyhledávání - "Guillermo H Giambartolomei"

Akademický článek

Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling

Autor: Julia Rodríguez, Julia De Santis Arévalo, Vida A. Dennis, Ana M. Rodríguez, Guillermo H. Giambartolomei

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

Inflammation plays a key role in the pathogenesis of neurobrucellosis where glial cell interactions are at the root of this pathological condition. In this study, we present evidence indicating that soluble factors secreted by Brucella abortus-infect

Externí odkaz: https://doaj.org/article/b7c08bf3e65946cd8509972070f6d062

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Akademický článek

Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital Challenge and Re-Challenge

Autor: Rajnish Sahu, Saurabh Dixit, Richa Verma, Skyla A. Duncan, Lula Smith, Guillermo H. Giambartolomei, Shree R. Singh, Vida A. Dennis

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Recently we reported the immune-potentiating capacity of a Chlamydia nanovaccine (PLGA-rMOMP) comprising rMOMP (recombinant major outer membrane protein) encapsulated in extended-releasing PLGA [poly (D, L-lactide-co-glycolide) (85:15)] nanoparticles

Externí odkaz: https://doaj.org/article/78e0de3165c943a5b8f97f0f028f771a

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Akademický článek

Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses

Autor: M. Ayelén Milillo, Aldana Trotta, Agustina Serafino, José Luis Marin Franco, Fábio V. Marinho, Julieta Alcain, Melanie Genoula, Luciana Balboa, Sergio Costa Oliveira, Guillermo H. Giambartolomei, Paula Barrionuevo

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Brucella abortus, the causative agent of brucellosis, displays many resources to evade T cell responses conducive to persist inside the host. Our laboratory has previously showed that infection of human monocytes with B. abortus down-modulates the IF

Externí odkaz: https://doaj.org/article/a30c7fe1d2514ce590db3947c8295e72

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Akademický článek

The Chlamydia M278 Major Outer Membrane Peptide Encapsulated in the Poly(lactic acid)-Poly(ethylene glycol) Nanoparticulate Self-Adjuvanting Delivery System Protects Mice Against a Chlamydia muridarum Genital Tract Challenge by Stimulating Robust Systemic and Local Mucosal Immune Responses

Autor: Richa Verma, Rajnish Sahu, Saurabh Dixit, Skyla A. Duncan, Guillermo H. Giambartolomei, Shree R. Singh, Vida A. Dennis

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Recently, we reported that our PPM chlamydial nanovaccine [a biodegradable co-polymeric PLA-PEG (poly(lactic acid)-poly(ethylene glycol))-encapsulated M278 peptide (derived from the major outer membrane protein (MOMP) of Chlamydia)] exploits the cave

Externí odkaz: https://doaj.org/article/67666e86bf114b79b60c51726a119eee

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Akademický článek

Brucella abortus Traverses Brain Microvascular Endothelial Cells Using Infected Monocytes as a Trojan Horse

Autor: María C. Miraglia, Ana M. Rodriguez, Paula Barrionuevo, Julia Rodriguez, Kwang S. Kim, Vida A. Dennis, M. Victoria Delpino, Guillermo H. Giambartolomei

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Neurobrucellosis is an inflammatory disease caused by the invasion of Brucella spp. to the central nervous system (CNS). The pathogenesis of the disease is not well characterized; however, for Brucella to gain access to the brain parenchyma, traversi

Externí odkaz: https://doaj.org/article/92d1f18be7b6460ebc264564eb3498a0

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Akademický článek

Platelets Promote Brucella abortus Monocyte Invasion by Establishing Complexes With Monocytes

Autor: Aldana Trotta, Lis N. Velásquez, M. Ayelén Milillo, M. Victoria Delpino, Ana M. Rodríguez, Verónica I. Landoni, Guillermo H. Giambartolomei, Roberto G. Pozner, Paula Barrionuevo

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Brucellosis is an infectious disease elicited by bacteria of the genus Brucella. Platelets have been extensively described as mediators of hemostasis and responsible for maintaining vascular integrity. Nevertheless, they have been recently involved i

Externí odkaz: https://doaj.org/article/1d5abb9254e4442fbc398a182875beee

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Akademický článek

B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway.

Autor: M Ayelén Milillo, Lis N Velásquez, Aldana Trotta, M Victoria Delpino, Fábio V Marinho, Luciana Balboa, Mónica Vermeulen, Sonia L Espindola, Nahuel Rodriguez-Rodrigues, Gabriela C Fernández, Sergio Costa Oliveira, Guillermo H Giambartolomei, Paula Barrionuevo

Publikováno v: PLoS Pathogens, Vol 13, Iss 8, p e1006527 (2017)

Despite eliciting a potent CD8+ T cell response, Brucella abortus is able to persist and establish a chronic infection inside its host. We have previously reported that the infection of human monocytes/macrophages with B. abortus inhibits the IFN-γ-

Externí odkaz: https://doaj.org/article/7891cb24c924458f9432aa2e45d3c711

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Akademický článek

CCL20 and Beta-Defensin 2 Production by Human Lung Epithelial Cells and Macrophages in Response to Brucella abortus Infection.

Autor: M Soledad Hielpos, Mariana C Ferrero, Andrea G Fernández, Josefina Bonetto, Guillermo H Giambartolomei, Carlos A Fossati, Pablo C Baldi

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140408 (2015)

Both CCL20 and human β-defensin 2 (hBD2) interact with the same membrane receptor and display chemotactic and antimicrobial activities. They are produced by airway epithelia in response to infectious agents and proinflammatory cytokines. Whereas Bru

Externí odkaz: https://doaj.org/article/b012483961a34b379be93062bdd2434b

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Inhibition of antigen presentation by Brucella: many more than many ways

Autor: Paula Barrionuevo, Guillermo H. Giambartolomei

Publikováno v: Microbes and Infection. 21:136-142

Brucella infection activates the immune system and favors the differentiation of CD4+ and CD8+ T cells. To persist during a long time inside macrophages evading immune surveillance of these T cells the pathogen must exploit different evasion strategi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540bcf6919d8d14504109d75290e5c45
https://doi.org/10.1016/j.micinf.2018.12.004

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Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital Challenge and Re-Challenge

Autor: Saurabh Dixit, Guillermo H. Giambartolomei, Skyla A. Duncan, Shree R. Singh, Rajnish Sahu, Vida A. Dennis, Lula Smith, Richa Verma

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
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Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2f57a4cd32893569aeba13c7a9a3c8
https://www.frontiersin.org/articles/10.3389/fimmu.2021.660932/full

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