Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Guillermo Gerona-Navarro"'
Autor:
Raffaella Di Micco, Barbara Fontanals-Cirera, Vivien Low, Panagiotis Ntziachristos, Stephanie K. Yuen, Claudia D. Lovell, Igor Dolgalev, Yoshiya Yonekubo, Guangtao Zhang, Elena Rusinova, Guillermo Gerona-Navarro, Marta Cañamero, Michael Ohlmeyer, Iannis Aifantis, Ming-Ming Zhou, Aristotelis Tsirigos, Eva Hernando
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 234-247 (2014)
Summary: Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, reg
Externí odkaz:
https://doaj.org/article/637cc06e452f4f3b8354d8e5926294d6
Publikováno v:
Proteins
Bromodomains (BrDs), a conserved structural module in chromatin-associated proteins, are well known for recognizing ε-N-acetyl lysine residues on histones. One of the most relevant BrDs is BRD4, a tandem bromodomain containing protein (BrD1 and BrD2
Publikováno v:
Protein & Peptide Letters. 25:1076-1089
Background Interactions between proteins play a key role in nearly all cellular process, and therefore, its dysregulation may lead to many different types of cellular dysfunctions. Hence, pathologic Protein-Protein Interactions (PPIs) constitute high
Autor:
Leutrim Kelmendi, Guillermo Gerona-Navarro, Milana Sapozhnikov, Hunter W. Korsmo, Khadija Wilson, Adam Herskovits, Maisha Chowdhury, Haleem Alkasimi, Flavia Barragan, Gan Zhang, Nissim Levy, Yoel Rodríguez
Publikováno v:
Angewandte Chemie International Edition. 57:17073-17078
Stapled peptides have emerged as a new class of therapeutics to effectively target intractable protein-protein interactions. Thus, efficient and versatile methods granting easy access to this class of compounds and expanding the scope(s) of the curre
Autor:
de Vega, Felipe L. Pérez-Gordillo, Maria Jesús Pérez, de la Rosa, Rosario González-Muñiz, Guillermo Gerona-Navarro, Yoel Rodríguez, Diego Alvarez, Martín-Martínez, Mercedes
Aldosterone plays an important role in the regulation of blood pressure, body fluid, and electrolyte homeostasis. Overactivation of aldosterone/mineralocorticoid receptor (MR) pathway leads to hypertension, atherosclerosis, vascular damage, heart fai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5582edacb8b66229249f1e276c8e4436
Publikováno v:
Cancer Research. 80:PO-008
Cancer is a genetic disease, but its development also involves multiple epigenetic alterations. Epigenetics regulates transcription by modulating chromatin architecture through different mechanisms. Hence, dysregulation of such mechanisms can result
Autor:
Elena Rusinova, Ming-Ming Zhou, Guillermo Gerona-Navarro, Michael Ohlmeyer, Iannis Aifantis, Vivien Low, Barbara Fontanals-Cirera, Marta Cañamero, Aristotelis Tsirigos, Yoshiya Yonekubo, Eva Hernando, Raffaella Di Micco, Panagiotis Ntziachristos, Stephanie Yuen, Guangtao Zhang, Igor Dolgalev, Claudia D. Lovell
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 234-247 (2014)
CELL REPORTS
Cell reports
CELL REPORTS
Cell reports
Summary: Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, reg
Autor:
Mercedes Martín-Martínez, Diego Alvarez de la Rosa, Rosario González-Muñiz, Yoel Rodríguez, Ming-Ming Zhou, Guillermo Gerona-Navarro, Felipe L. Pérez-Gordillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Steroidal mineralocorticoid receptor (MR) antagonists are used for treatment of a range of human diseases, but they present challenging issues of complex chemical synthesis, undesirable physical properties, and poor selectivity along with unwanted si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f461621ead9778dc252f1b1ac5d41ea7
http://hdl.handle.net/10261/152028
http://hdl.handle.net/10261/152028
Autor:
Jasbir Kaur, Bridget Matikainen, Gregory Moy, Ming-Ming Zhou, Patrizia Casaccia, Yoel Rodríguez, Lei Zeng, Guillermo Gerona-Navarro, Alexander N. Plotnikov, Adam Vincek, Mar Gacias, Guangtao Zhang, Elena Rusinova, Jennifer Joshua
Publikováno v:
Chemistry & Biology. 21(7):841-854
Lysine acetylation regulates gene expression through modulating protein-protein interactions in chromatin. Chemical inhibition of acetyl-lysine binding bromodomains of the major chromatin regulators BET (bromodomain and extra-terminal domain) protein
Autor:
M. Angeles Jiménez, Mercedes Martín-Martínez, Samie R. Jaffrey, Rosario González-Muñiz, Clara M. Santiveri, David Andreu, Beatriz G. de la Torre, M. Teresa García-López, Ramiro D. Almeida, Guillermo Gerona-Navarro, José Luis Baeza
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Based on β-turn-like BDNF loops 2 and 4, involved in receptor interaction, cyclic peptide replicas were designed, synthesized and tested. In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini