Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Guillermo Fernandez de Troconiz"'
Autor:
Michail Tsakos, Chun Yuen Leung, Cyrus M. Lacbay, Guillermo Fernandez De Troconiz, Albert M. Berghuis, Jaeok Park, Alexios N. Matralis, Youla S. Tsantrizos
Publikováno v:
Journal of Medicinal Chemistry. 60:2119-2134
The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP). FPP plays a crucial role in the post-translational prenylation of sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7b0b7dc66e706f498e1dc646f31eab
https://doi.org/10.1021/acs.jmedchem.6b01888
https://doi.org/10.1021/acs.jmedchem.6b01888
Publikováno v:
The Journal of Organic Chemistry. 79:5173-5181
A regioselective addition of isocyanates to fluoroalkylated α,β-unsaturated imines 1 is described. Fluoroalkyl-substituted triazinane-2,4-diones 4 are obtained by the reaction of phenyl isocyanate with fluorinated imines 1, while fluorinated dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e668ede8a290d9b4dad639849bf825cd
https://doi.org/10.1021/jo500745u
https://doi.org/10.1021/jo500745u
Publikováno v:
Tetrahedron. 67:1575-1579
A simple and efficient synthesis of fluoroalkylated α-amino nitrile ( 4 ) derivatives by regioselective 1,2-addition of trimethylsilyl cyanide to fluoroalkylated α,β-unsaturated imines ( 1 ) is described. Fluoroalkylated β-amino nitriles ( 7 ) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd1141075a1a6dff356ff8aac80bd47
https://doi.org/10.1016/j.tet.2010.12.046
https://doi.org/10.1016/j.tet.2010.12.046
Autor:
Jose Maria Ezpeleta, Francisco Palacios, Ana M. Ochoa de Retana, Guillermo Fernandez de Troconiz, Sergio Pascual
Publikováno v:
European Journal of Organic Chemistry. 2010:6618-6626
A simple and efficient synthesis of vinylogous fluoroalkylated β-amino mono- (4) and diester (9) derivatives by the regioselective 1,2-addition of enolates derived from alkyl acetates or diethyl malonate to fluoroalkylated α,β-unsaturated imines (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20fda1038aef81d5f5c8477b7b932fe
https://doi.org/10.1002/ejoc.201000948
https://doi.org/10.1002/ejoc.201000948
Autor:
Francisco Palacios, Ana M. Ochoa de Retana, Guillermo Fernandez de Troconiz, Sergio Pascual, Julen Oyarzabal
Publikováno v:
The Journal of Organic Chemistry. 73:4568-4574
A simple and efficient stereoselective synthesis of fluorine containing beta-aminophosphonates by reduction of beta-enaminophosphonates is described. Reduction with sodium cyanborohydride in the presence of zinc chloride and the catalytic hydrogenati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907b8accf1aaf0a7edf5092a8e9fc6d3
https://doi.org/10.1021/jo8005667
https://doi.org/10.1021/jo8005667
Publikováno v:
ChemInform. 45
A regioselective addition of isocyanates to fluoroalkylated α,β-unsaturated imines 1 is described. Fluoroalkyl-substituted triazinane-2,4-diones 4 are obtained by the reaction of phenyl isocyanate with fluorinated imines 1, while fluorinated dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b333495a8c7ba6aee796b24caf8a1aaa
https://doi.org/10.1002/chin.201447031
https://doi.org/10.1002/chin.201447031
Autor:
Francisco Palacios, Ana M. Ochoa de Retana, Jose Maria Ezpeleta, Sergio Pascual, Guillermo Fernandez de Troconiz
Publikováno v:
ChemInform. 45
Base-mediated treatment of the imines (I) with the nitriles (I) and (V) is found to allow convenient and regioselective formation of stable primary enamines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c770b7bc5a1eb56e061cbf724f28874
https://doi.org/10.1002/chin.201406174
https://doi.org/10.1002/chin.201406174
Publikováno v:
ChemInform. 42
An efficient synthesis of fluoroalkylated α-aminonitrile derivatives is presented by regiospecific 1,2-addition of TmsCN to isolated [cf.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7d4bcffd587a56027c70171666df6a
https://doi.org/10.1002/chin.201123067
https://doi.org/10.1002/chin.201123067
Autor:
Ana M. Ochoa de Retana, Francisco Palacios, Guillermo Fernandez de Troconiz, Jose Maria Ezpeleta, Sergio Pascual
Publikováno v:
ChemInform. 42
A simple, mild and convenient method for the synthesis of vinylogous fluoroalkylated -amino esters (IV) and (VI) by 1,2-addition of enolates to fluoroalkylated α,β-unsaturated imines is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f814fd39456da7ba7edf8ee65481fb
https://doi.org/10.1002/chin.201114081
https://doi.org/10.1002/chin.201114081
Autor:
Francisco Palacios, Julen Oyarzabal, Ana M. Ochoa de Retana, Sergio Pascual, Guillermo Fernandez de Troconiz
Publikováno v:
ChemInform. 39
A simple and efficient stereoselective synthesis of fluorine containing β-aminophosphonates by reduction of β-enaminophosphonates is described. Reduction with sodium cyanborohydride in the presence of zinc chloride and the catalytic hydrogenation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9176c8c08395e6382c142fec4f1f7cc1
https://doi.org/10.1002/chin.200843178
https://doi.org/10.1002/chin.200843178