Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Guillermo Federico Spitzmaul"'
Autor:
Ezequiel Ignacio Rías, Eugenio Manuel Aztiria, Leonardo Raul Dionisio, Camila Carignano, Guillermo Federico Spitzmaul, Esteban Pablo Barila
Publikováno v:
Neuroscience. 410:202-216
DFNA2 is a progressive deafness caused by mutations in the voltage-activated potassium channel KCNQ4. Hearing loss develops with age from a mild increase in the hearing threshold to profound deafness. Studies using transgenic mice for Kcnq4 expressed
Autor:
Makiko Shimizu, Guillermo Federico Spitzmaul, Maximiliano Alda, Sofia Stupniki, Hiroshi Yamazaki, Eugenio Manuel Aztiria, Saki Oyama, Leonardo Raul Dionisio
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Flavin-containing monooxygenase 3 (FMO3) is a polymorphic drug metabolizing enzyme associated with the genetic disorder trimethylaminuria. We phenotyped a white Argentinian 11-year-old girl by medical sensory evaluation. After pedigree analysis with
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1964-1973
The neuronal nicotinic acetylcholine receptor α4β2 forms pentameric proteins with two alternate stoichiometries. The high-sensitivity receptor is related to (α4)2(β2)3 stoichiometry while the low-sensitivity receptor to (α4)3(β2)2 stoichiometry
Autor:
Guillermo Federico Spitzmaul, Martijn Schonewille, William Wisden, Chris I. De Zeeuw, Patricia Seja, Thomas J. Jentsch, Ilse Klein, Aleksandra Badura, Christian A. Hübner, York Rudhard
Publikováno v:
The EMBO Journal. 31:1217-1230
Cerebellar cortical throughput involved in motor control comprises granule cells (GCs) and Purkinje cells (PCs), both of which receive inhibitory GABAergic input from interneurons. The GABAergic input to PCs is essential for learning and consolidatio
Autor:
Anastassios V. Tzingounis, Thomas J. Jentsch, Matthias Heidenreich, Henrik Sindal Jensen, Tatjana Kharkovets, Roger A. Nicoll, Guillermo Federico Spitzmaul
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 107(22): 10232–10237
Mutations in KCNQ2 and KCNQ3 voltage-gated potassium channels lead to neonatal epilepsy as a consequence of their key role in regulating neuronal excitability. Previous studies in the brain have focused primarily on these KCNQ family members, which c
Publikováno v:
British Journal of Pharmacology. 157:804-817
Background and purpose: Many local anaesthetics are non-competitive inhibitors of nicotinic receptors (acetylcholine receptor, AChR). Proadifen induces a high-affinity state of the receptor, but its mechanism of action and that of an analogue, adiphe
Autor:
Maria Jose de Rosa, Marcelo Daniel Costabel, Jeremias Corradi, Cecilia Bouzat, Guillermo Federico Spitzmaul
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The adult form of the nicotinic acetylcholine receptor (AChR) consists of five subunits (α2βɛδ), each having four transmembrane domains (M1–M4). The atomic model of the nicotinic acetylcholine receptor shows that the pore-lining M2 domains make
Autor:
Guillermo Federico Spitzmaul, James R. Trudell, Hugo Rubén Arias, Cecilia Beatriz Bouzat, Pankaj Bhumireddy
Publikováno v:
Biochemistry. 45:2014-2026
We investigated the molecular mechanisms and the binding site location for the fluorophor crystal violet (CrV), a noncompetitive antagonist of the nicotinic acetylcholine receptor (AChR). To this end, radiolabeled competition binding, fluorescence sp
Publikováno v:
Molecular pharmacology. 68(5)
The receptor chimera 7–5HT3A has served as a prototype for understanding the pharmacology of 7 neuronal nicotinic receptors, yet its low single channel conductance has prevented studies of the activation kinetics of single receptor channels. In thi
Autor:
Palmer Taylor, Guillermo Federico Spitzmaul, Steven M. Sine, Hai Long Wang, Scott B. Hansen, Cecilia Bouzat, Diego Hernán Rayes, Fernanda Gumilar
Neurotransmitter receptors from the Cys-loop superfamily couple the binding of agonist to the opening of an intrinsic ion pore in the final step in rapid synaptic transmission. Although atomic resolution structural data have recently emerged for indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8baba385d5715452f18ab33c545ba4
https://www.nature.com/articles/nature02753
https://www.nature.com/articles/nature02753