Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Guillermo E. Taccioli"'
Autor:
Guillermo E. Taccioli, Thomas D. Stamato, Jose L. Garcia-Perez, John V. Moran, Tammy A. Morrish, JoAnn Sekiguchi
Publikováno v:
Nature. 446:208-212
Long interspersed element-1 (LINE-1 or L1) elements are abundant, non-long-terminal-repeat (non-LTR) retrotransposons that comprise approximately 17% of human DNA. The average human genome contains approximately 80-100 retrotransposition-competent L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee331be13090728fa73a70b9a0bf80
https://doi.org/10.1038/nature05560
https://doi.org/10.1038/nature05560
Autor:
Guillermo E. Taccioli
The vast diversity of the antibodies generated by B cells derives largely from the fact that the variable portion of these molecules is assembled differently in each individual lymphocyte using a large number of individual genes. Three types of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c89984dc4b8f36c57c97dc224850fa2b
https://doi.org/10.1128/9781555816148.ch7
https://doi.org/10.1128/9781555816148.ch7
Autor:
Guillermo E. Taccioli, Anna Genescà, Josep Egozcue, Laura Tusell, Marta Martín, Maria A. Blasco, Laura Latre, George Iliakis, Isabel Jaco
Publikováno v:
Cancer Research. 65:10223-10232
Combined cytogenetic and biochemical approaches were used to investigate the contributions of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) in the maintenance of genomic stability in nonirradiated and irradiated primary mouse embry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09801d7a443f391bdf811e32caf98914
https://doi.org/10.1158/0008-5472.can-05-0932
https://doi.org/10.1158/0008-5472.can-05-0932
Autor:
Joanna Wesoly, Maria A. Blasco, Purificación Muñoz, Isabel Jaco, Guillermo E. Taccioli, Fermín A. Goytisolo, Susan M. Bailey
Publikováno v:
Molecular and Cellular Biology. 23:5572-5580
The homologous recombination (HR) DNA repair pathway participates in telomere length maintenance in yeast but its putative role at mammalian telomeres is unknown. Mammalian Rad54 is part of the HR machinery, and Rad54-deficient mice show a reduced HR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f48a523097c4f2d7a083459711c2afc
https://doi.org/10.1128/mcb.23.16.5572-5580.2003
https://doi.org/10.1128/mcb.23.16.5572-5580.2003
Publikováno v:
Journal of Biological Chemistry. 278:22136-22143
Increased sensitivity to ionizing radiation (IR) has been shown to be due to defects in DNA double-strand break repair machinery. The major pathway in mammalian cells dedicated to the repair of DNA double-strand breaks is by the nonhomologous end-joi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8fd97ac48eb675bc1f2e0c30719ac22
https://doi.org/10.1074/jbc.m301579200
https://doi.org/10.1074/jbc.m301579200
Autor:
Mark A. Batzer, Jeremy S. Myers, Nicolas Gilbert, Tammy A. Morrish, Thomas D. Stamato, John V. Moran, Guillermo E. Taccioli, Bethaney J. Vincent
Publikováno v:
Nature Genetics. 31:159-165
Long interspersed elements (LINE-1s) are abundant retrotransposons in mammalian genomes that probably retrotranspose by target site-primed reverse transcription (TPRT). During TPRT, the LINE-1 endonuclease cleaves genomic DNA, freeing a 3' hydroxyl t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68f5463e9113aa85de299e3eb2b32cd
https://doi.org/10.1038/ng898
https://doi.org/10.1038/ng898
Autor:
Guillermo E. Taccioli, Kevin D. Brown, Sanjeev Shangary, R. Baskaran, Bobby G. Ng, Jack C. Yalowich, Aaron W. Adamson, Scott Edmonson, Tej K. Pandita
Publikováno v:
Journal of Biological Chemistry. 275:30163-30168
Ionizing radiation (IR) treatment results in activation of the nonreceptor tyrosine kinase c-Abl because of phosphorylation by ATM. In vitro evidence indicates that DNA-dependent protein kinase (DNA-PK) can also phosphorylate and thus potentially act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8e3c2b5dbe19c6ec24f58de7f77245
https://doi.org/10.1074/jbc.m004302200
https://doi.org/10.1074/jbc.m004302200
Autor:
S. T. Rottinghaus, Penny A. Jeggo, Guillermo E. Taccioli, Maria I. Torres-Arzayus, B. K. Singleton
Publikováno v:
Molecular and Cellular Biology. 19:3267-3277
Ku is a heterodimeric protein with double-stranded DNA end-binding activity that operates in the process of nonhomologous end joining. Ku is thought to target the DNA-dependent protein kinase (DNA-PK) complex to the DNA and, when DNA bound, can inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1077e24ee549b77cd175106c06bb28
https://doi.org/10.1128/mcb.19.5.3267
https://doi.org/10.1128/mcb.19.5.3267
Autor:
Stephen P. Jackson, Ann Marshak Rothstein, Xie H. Xiang, Ann Priestley, Guillermo E. Taccioli, Maria I.Torres Arzayus, Aldo G Amatucci, Victoria L. M. Herrera, Heather Beamish, Penny A Jeggo, David A. Gell
Publikováno v:
Immunity. 9(3):355-366
The DNA-dependent protein kinase is a mammalian protein complex composed of Ku70, Ku80, and DNA-PKcs subunits that has been implicated in DNA double-strand break repair and V(D)J recombination. Here, by gene targeting, we have constructed a mouse wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b110aaab3758b90c51752ebf60005334
Autor:
B. K. Singleton, Maria C. Muhlmann-Diaz, Tracy Blunt, Graeme C. M. Smith, Stephen P. Jackson, Anne Priestley, P. A. Jeggo, Leonard C. Schalkwyk, Guillermo E. Taccioli, A. G. Amatucci, Joel S. Bedford, David A. Gell, Heather Beamish
Publikováno v:
Nucleic Acids Research. 26:1965-1973
The catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) is a member of a sub-family of phosphatidylinositol (PI) 3-kinases termed PIK-related kinases. A distinguishing feature of this sub-family is the presence of a conserved C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5900e08c19c3005f4491f00bcdee74e
https://doi.org/10.1093/nar/26.8.1965
https://doi.org/10.1093/nar/26.8.1965