Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts.

Autor: Visnu Chaparro, Louis-Philippe Leroux, Laia Masvidal, Julie Lorent, Tyson E Graber, Aude Zimmermann, Guillermo Arango Duque, Albert Descoteaux, Tommy Alain, Ola Larsson, Maritza Jaramillo

Publikováno v: PLoS Pathogens, Vol 16, Iss 6, p e1008291 (2020)

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a chronic infection which is fatal when untreated. Herein, we investigated whether in addition to altering transcription, L. donovani modulates host mRNA translat

Externí odkaz: https://doaj.org/article/977c1b89dc2b49998f3096020cc964a2

The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole.

Autor: Guillermo Arango Duque, Armando Jardim, Étienne Gagnon, Mitsunori Fukuda, Albert Descoteaux

Publikováno v: PLoS Pathogens, Vol 15, Iss 7, p e1007982 (2019)

To colonize phagocytes, Leishmania subverts microbicidal processes through components of its surface coat that include lipophosphoglycan and the GP63 metalloprotease. How these virulence glycoconjugates are shed, exit the parasitophorous vacuole (PV)

Externí odkaz: https://doaj.org/article/0b951d0792104026a010932e7b575405

Sec22b Regulates Inflammatory Responses by Controlling the Nuclear Translocation of NF-κB and the Secretion of Inflammatory Mediators

Autor: Aymeric Fabié, Simona Stäger, Julien Descoteaux, Albert Descoteaux, Guillermo Arango Duque, Christine Matte, Renaud Dion

Publikováno v: The Journal of Immunology. 207:2297-2309

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) regulate the vesicle transport machinery in phagocytic cells. Within the secretory pathway, Sec22b is an endoplasmic reticulum–Golgi intermediate compartment (ERGIC)-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6571e74d0537c51cb5f82ccaf0f9022c
https://doi.org/10.4049/jimmunol.2100258

Sec22b regulates inflammatory responses by controlling the nuclear translocation of NF-κB

Autor: Aymeric Fabié, Guillermo Arango Duque, Julien Descoteaux, Albert Descoteaux, Renaud Dion, Simona Stäger

Soluble NSF attachment receptor (SNARE) proteins regulate the vesicle transport machinery in phagocytic cells. Within the secretory pathway, Sec22b is an ER-Golgi intermediate compartment (ERGIC)-resident SNARE that controls phagosome maturation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed290cdbbfc3d3dd71b3402a439ba6a7
https://doi.org/10.1101/2020.09.20.305383

Leishmania braziliensis: Strain-Specific Modulation of Phagosome Maturation

Autor: Guillermo Arango Duque, Tamara da Silva Vieira, Rodrigo Pedro Soares, Célia Maria Ferreira Gontijo, Albert Descoteaux, Kévin Ory

Publikováno v: Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.319. ⟨10.3389/fcimb.2019.00319⟩
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)

International audience; Leishmania (Viannia) braziliensis is responsible for the largest number of American tegumentary leishmaniasis (ATL) in Brazil. ATL can present several clinical forms including typical (TL) and atypical (AL) cutaneous and mucoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20996dce87b17d057f8859cea9205fd9
http://europepmc.org/articles/PMC6743224