Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Guillermo A. Altenberg"'
Autor:
Jon Y. Takemoto, Guillermo A. Altenberg, Naveena Poudyal, Yagya P. Subedi, Cheng-Wei T. Chang
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Widely-used Streptomyces-derived antibacterial aminoglycosides have encountered challenges because of antibiotic resistance and toxicity. Today, they are largely relegated to medicinal topical applications. However, chemical modification to amphiphil
Externí odkaz:
https://doaj.org/article/f849650328ed4a728f2130c5c872758b
Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular
Externí odkaz:
https://doaj.org/article/1fc6a16f57504afcbd3a1a37b8ac4354
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Membrane proteins (MPs) are essential to many organisms’ major functions. They are notorious for being difficult to isolate and study, and mimicking native conditions for studies in vitro has proved to be a challenge. Lipid nanodiscs are among the
Externí odkaz:
https://doaj.org/article/6c244f0aea244dc3b0658ac166d05f12
Autor:
Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Aníbal A. Vargas
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/f138718c5a604835bb97a8342a8e119a
Autor:
Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Aníbal A. Vargas
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively. Under physiological conditions, hemichannels have a very low
Externí odkaz:
https://doaj.org/article/fc85ee9db0084b9fbe39cd93fda06e80
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Styrene-maleic acid copolymers allow for solubilization and reconstitution of membrane proteins into nanodiscs. These polymer-encased nanodiscs are promising platforms for studies of membrane proteins in a near-physiologic environment withou
Externí odkaz:
https://doaj.org/article/a51c6437cf824dffbda713530a5202a9
Autor:
Mariana C. Fiori, Srinivasan Krishnan, Abbey Kjellgren, Luis G. Cuello, Guillermo A. Altenberg
Publikováno v:
Molecules, Vol 22, Iss 12, p 2063 (2017)
In addition to gap junctional channels that mediate cell-to-cell communication, connexins form hemichannels that are present at the plasma membrane. Since hemichannels are permeable to small hydrophilic compounds, including metabolites and signaling
Externí odkaz:
https://doaj.org/article/5c1c3336fcec448b8c09b6046c450258
Publikováno v:
Chemical Society Reviews. 51:1702-1728
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations have shown great promise for targeted drug delivery with improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3ed3fe0f699c9da66ba91ca3469031
https://doi.org/10.1039/d1cs01074c
https://doi.org/10.1039/d1cs01074c
Autor:
Ainoa Fernández-Olivares, Eduardo Durán-Jara, Daniel A. Verdugo, Mariana C. Fiori, Guillermo A. Altenberg, Jimmy Stehberg, Iván Alfaro, Juan Francisco Calderón, Mauricio A. Retamal
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7252
Connexin (Cxs) hemichannels participate in several physiological and pathological processes, but the molecular mechanisms that control their gating remain elusive. We aimed at determining the role of extracellular cysteines (Cys) in the gating and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e9db387e3076834f76cc52935d07f9
https://pubmed.ncbi.nlm.nih.gov/35806258
https://pubmed.ncbi.nlm.nih.gov/35806258
Autor:
Mariana C. Fiori, Guillermo A. Altenberg, Elizabeth Kamilar, Hongjun Liang, Wan Zheng, Geuel Simiyu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Membrane proteins can be reconstituted in polymer-encased nanodiscs for studies under near-physiological conditions and in the absence of detergents, but traditional styrene-maleic acid copolymers used for this purpose suffer severely from buffer inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea71a0479a0a77b6701a54af07dcc2f
http://link.springer.com/article/10.1038/s41598-020-66852-7
http://link.springer.com/article/10.1038/s41598-020-66852-7