Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Guillermina Lozano"'
Autor:
Chang Sun, Yuan Qi, Natalie Fowlkes, Nina Lazic, Xiaoping Su, Guillermina Lozano, Amanda R. Wasylishen
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-9 (2023)
Abstract Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including c
Externí odkaz:
https://doaj.org/article/a2b8e003959247d18bd59dc80dcac901
Autor:
Javier Octavio Mejía-Hernández, Simon P. Keam, Reem Saleh, Fenella Muntz, Stephen B. Fox, David Byrne, Arielle Kogan, Lokman Pang, Jennifer Huynh, Cassandra Litchfield, Franco Caramia, Guillermina Lozano, Hua He, James M. You, Shahneen Sandhu, Scott G. Williams, Ygal Haupt, Sue Haupt
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-17 (2022)
Abstract Understanding prostate cancer onset and progression in order to rationally treat this disease has been critically limited by a dire lack of relevant pre-clinical animal models. We have generated a set of genetically engineered mice that mimi
Externí odkaz:
https://doaj.org/article/72de5aef0f664a85b0c01a44bc290580
Autor:
Vrutant V. Shah, Aundrietta D. Duncan, Shiming Jiang, Sabrina A. Stratton, Kendra L. Allton, Clinton Yam, Abhinav Jain, Patrick M. Krause, Yue Lu, Shirong Cai, Yizheng Tu, Xinhui Zhou, Xiaomei Zhang, Yan Jiang, Christopher L. Carroll, Zhijun Kang, Bin Liu, Jianjun Shen, Mihai Gagea, Sebastian M. Manu, Lei Huo, Michael Gilcrease, Reid T. Powell, Lei Guo, Clifford Stephan, Peter J. Davies, Jan Parker-Thornburg, Guillermina Lozano, Richard R. Behringer, Helen Piwnica-Worms, Jeffrey T. Chang, Stacy L. Moulder, Michelle Craig Barton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Human metaplastic breast cancers (MpBC) are a rare, aggressive subclass of triple-negative breast cancers. Here, the authors show over-expression of histone reader TRIM24 is sufficient to generate tumors with a molecular signature of metabolic dysfun
Externí odkaz:
https://doaj.org/article/d198e1ab2b18460f8fd9661445a6e392
Autor:
Chang Sun, Jeannelyn S. Estrella, Elizabeth M. Whitley, Gilda P. Chau, Guillermina Lozano, Amanda R. Wasylishen
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX are frequently mutated in pancreatic neuroendocrine tumors; however, the underlying mechanisms of h
Externí odkaz:
https://doaj.org/article/1d796c1cc30249a89d86ee96573ada87
Autor:
Xin Zhou, Allyson Beilter, Zhaohui Xu, Ruli Gao, Shunbin Xiong, Adriana Paulucci-Holthauzen, Guillermina Lozano, Benoit de Crombrugghe, Richard Gorlick
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Abstract The developmental origins of mesenchymal progenitor cells (MPCs) and molecular machineries regulating their fate and differentiation are far from defined owing to their complexity. Osteoblasts and adipocytes are descended from common MPCs. T
Externí odkaz:
https://doaj.org/article/eed50df3b8af4e8994f051ac95c9838e
Autor:
Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P. Speed, Ygal Haupt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males. Males are further disadvantaged by a failure to shield agai
Externí odkaz:
https://doaj.org/article/1a749f75f57f428ea7b81ae7e79a67f1
Autor:
Edith A Perez, Elizabeth M Jaffee, John Whyte, Cheryl A Boyce, John D Carpten, Guillermina Lozano, Raymond M Williams, Karen M Winkfield, David Bernstein, Sung Poblete
Publikováno v:
JMIR Cancer, Vol 7, Iss 3, p e25621 (2021)
BackgroundRacial and ethnic diversity in clinical trials for cancer treatment is essential for the development of treatments that are effective for all patients and for identifying potential differences in toxicity between different demographics. Min
Externí odkaz:
https://doaj.org/article/1bd1479c544848e48d2f9a0e088c2bc1
Autor:
Rama Soundararajan, Paul Viscuse, Patrick Pilie, Jingjing Liu, Souzana Logotheti, Caddie Laberiano Fernández, Daniele Lorenzini, Anh Hoang, Wei Lu, Luisa Maren Solis Soto, Ignacio I. Wistuba, Mingchu Xu, Xingzhi Song, Peter D. A. Shepherd, Nora M. Navone, Rebecca S. S. Tidwell, Guillermina Lozano, Christopher Logothetis, Jianhua Zhang, James P. Long, Marcos R. Estecio, Vasiliki Tzelepi, Ana M. Aparicio
Publikováno v:
Cancers, Vol 14, Iss 13, p 3233 (2022)
The aggressive variant prostate cancer molecular profile (AVPC-m), composed of combined defects in TP53, RB1 and PTEN, characterizes a subset of prostate cancers linked to androgen indifference and platinum sensitivity. To contribute to the optimizat
Externí odkaz:
https://doaj.org/article/6e92d7e81d304b3689c6750c1d5d1109
Autor:
Yun Zhang, Shunbin Xiong, Bin Liu, Vinod Pant, Francis Celii, Gilda Chau, Ana C. Elizondo-Fraire, Peirong Yang, Mingjian James You, Adel K. El-Naggar, Nicholas E. Navin, Guillermina Lozano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Mutations in TP53 gene are very common in cancer development. Here the authors take advantage of murine models to show that somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.
Externí odkaz:
https://doaj.org/article/6f7368c1d73241eeac39f0f8b051d0b9
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193485 (2018)
Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model with which to study the biology of this disease and to develop therapeutics is lacking. On
Externí odkaz:
https://doaj.org/article/13739306d4ce4ef9a4cd85e110af2f32